G protein subunit alpha q (Q21102036)

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mammalian protein found in Homo sapiens

guanine nucleotide-binding protein alpha-q
epididymis secretory sperm binding protein
guanine nucleotide-binding protein G(q) subunit alpha
GNAQ
guanine nucleotide binding protein (G protein), q polypeptide

Language	Label	Description	Also known as
English	G protein subunit alpha q	mammalian protein found in Homo sapiens	guanine nucleotide-binding protein alpha-q epididymis secretory sperm binding protein guanine nucleotide-binding protein G(q) subunit alpha GNAQ guanine nucleotide binding protein (G protein), q polypeptide

Statements

1 reference

13 November 2019

UniProt protein ID

G protein alpha subunit, helical insertion

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P50148

G-protein alpha subunit, group Q

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P50148

P-loop containing nucleoside triphosphate hydrolase

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P50148

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

nucleotide binding

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50148

determination method

type 2A serotonin receptor binding

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50148

determination method

GTPase activator activity

determination method

1 reference

31 October 2017

beta-Arrestin 1 and Galphaq/11 coordinately activate RhoA and stress fiber formation following receptor stimulation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P50148&geneProductId=UniProtKB:P50148

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50148

determination method

metal ion binding

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50148

determination method

protein binding

determination method

5 references

8 April 2019

Regulation of G protein-coupled receptor activities by the platelet-endothelial cell adhesion molecule, PECAM-1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50148

determination method

8 April 2019

A retinoic acid receptor RARα pool present in membrane lipid rafts forms complexes with G protein αQ to activate p38MAPK

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50148

determination method

8 April 2019

Direct inhibition of the cold-activated TRPM8 ion channel by Gαq.

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50148

determination method

8 April 2019

β-Arrestin-1 directly interacts with Gαs and regulates its function

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50148

determination method

8 April 2019

ARF6 Is an Actionable Node that Orchestrates Oncogenic GNAQ Signaling in Uveal Melanoma

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50148

determination method

GTPase activity

determination method

3 references

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P50148&geneProductId=UniProtKB:P50148

determination method

31 October 2017

Platelet signal transduction defect with Galpha subunit dysfunction and diminished Galphaq in a patient with abnormal platelet responses

http://www.ebi.ac.uk/QuickGO/annotations?protein=P50148&geneProductId=UniProtKB:P50148

determination method

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P50148&geneProductId=UniProtKB:P50148

determination method

guanyl nucleotide binding

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50148

determination method

G protein-coupled receptor binding

determination method

1 reference

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P50148&geneProductId=UniProtKB:P50148

determination method

signal transducer activity

determination method

GTPase activity

determination method

3 references

8 April 2019

Platelet signal transduction defect with Galpha subunit dysfunction and diminished Galphaq in a patient with abnormal platelet responses

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50148

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50148

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50148

determination method

determination method

1 reference

8 April 2019

Interaction of the G-protein G11alpha with receptors and phosphoinositidase C: the contribution of G-protein palmitoylation and membrane association

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50148

determination method

determination method

1 reference

31 October 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P50148&geneProductId=UniProtKB:P50148

determination method

nuclear membrane

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50148

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50148

determination method

plasma membrane

determination method

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50148

determination method

8 April 2019

Interaction of the G-protein G11alpha with receptors and phosphoinositidase C: the contribution of G-protein palmitoylation and membrane association

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50148

determination method

8 April 2019

Interaction of folate receptor with signaling molecules lyn and G(alpha)(i-3) in detergent-resistant complexes from the ovary carcinoma cell line IGROV1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50148

determination method

photoreceptor outer segment

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50148

determination method

lysosomal membrane

determination method

1 reference

31 October 2017

Integral and associated lysosomal membrane proteins

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P50148&geneProductId=UniProtKB:P50148

determination method

determination method

1 reference

31 October 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P50148&geneProductId=UniProtKB:P50148

determination method

extracellular exosome

determination method

4 references

31 October 2017

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P50148&geneProductId=UniProtKB:P50148

determination method

31 October 2017

Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT)

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P50148&geneProductId=UniProtKB:P50148

determination method

31 October 2017

Proteomic analysis of podocyte exosome-enriched fraction from normal human urine

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P50148&geneProductId=UniProtKB:P50148

determination method

31 October 2017

Large-scale proteomics and phosphoproteomics of urinary exosomes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P50148&geneProductId=UniProtKB:P50148

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50148

determination method

heterotrimeric G-protein complex

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50148

determination method

lysosomal membrane

determination method

1 reference

8 April 2019

Integral and associated lysosomal membrane proteins

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50148

determination method

extracellular exosome

determination method

3 references

8 April 2019

Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT)

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50148

determination method

8 April 2019

Large-scale proteomics and phosphoproteomics of urinary exosomes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50148

determination method

8 April 2019

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50148

determination method

biological process

G protein-coupled acetylcholine receptor signaling pathway

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50148

determination method

skeletal system development

determination method

1 reference

31 October 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P50148&geneProductId=UniProtKB:P50148

determination method

negative regulation of protein kinase activity

determination method

1 reference

8 April 2019

Regulation of GSK-3beta and beta-Catenin by Galphaq in HEK293T cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50148

determination method

neuron remodeling

determination method

1 reference

31 October 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P50148&geneProductId=UniProtKB:P50148

determination method

embryonic digit morphogenesis

determination method

1 reference

31 October 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P50148&geneProductId=UniProtKB:P50148

determination method

protein stabilization

determination method

1 reference

8 April 2019

Regulation of GSK-3beta and beta-Catenin by Galphaq in HEK293T cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50148

determination method

blood coagulation

determination method

1 reference

8 April 2019

Platelet signal transduction defect with Galpha subunit dysfunction and diminished Galphaq in a patient with abnormal platelet responses

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50148

determination method

post-embryonic development

determination method

1 reference

31 October 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P50148&geneProductId=UniProtKB:P50148

determination method

regulation of melanocyte differentiation

determination method

1 reference

31 October 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P50148&geneProductId=UniProtKB:P50148

determination method

activation of phospholipase C activity

determination method

1 reference

8 April 2019

Molecular cloning of human G alpha q cDNA and chromosomal localization of the G alpha q gene (GNAQ) and a processed pseudogene

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50148

determination method

entrainment of circadian clock

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50148

determination method

platelet activation

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50148

determination method

forebrain neuron development

determination method

1 reference

31 October 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P50148&geneProductId=UniProtKB:P50148

determination method

heart development

determination method

1 reference

31 October 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P50148&geneProductId=UniProtKB:P50148

determination method

maternal behavior

determination method

1 reference

31 October 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P50148&geneProductId=UniProtKB:P50148

determination method

phototransduction, visible light

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50148

determination method

developmental pigmentation

determination method

1 reference

31 October 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P50148&geneProductId=UniProtKB:P50148

determination method

positive regulation of GTPase activity

determination method

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50148

determination method

action potential

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50148

determination method

adenylate cyclase-modulating G protein-coupled receptor signaling pathway

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50148

determination method

adenylate cyclase-activating G protein-coupled receptor signaling pathway

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50148

determination method

glutamate receptor signaling pathway

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50148

determination method

regulation of canonical Wnt signaling pathway

determination method

1 reference

8 April 2019

Regulation of GSK-3beta and beta-Catenin by Galphaq in HEK293T cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50148

determination method

Identifiers

MeSH descriptor ID

subject named as

GNAQ protein, human

0 references

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000286548

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000286548

ENSP00000391501

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000391501

PDB structure ID

1 reference

9 November 2015

http://www.uniprot.org/uniprot/P21279.txt?version=168

1 reference

9 November 2015

http://www.uniprot.org/uniprot/P21279.txt?version=168

1 reference

9 November 2015

http://www.uniprot.org/uniprot/P21279.txt?version=168

1 reference

9 November 2015

http://www.uniprot.org/uniprot/P21279.txt?version=168

1 reference

9 November 2015

http://www.uniprot.org/uniprot/P21279.txt?version=168

1 reference

9 November 2015

http://www.uniprot.org/uniprot/P21279.txt?version=168

1 reference

9 November 2015

http://www.uniprot.org/uniprot/P21279.txt?version=168

1 reference

9 November 2015

http://www.uniprot.org/uniprot/P21279.txt?version=168

1 reference

9 November 2015

http://www.uniprot.org/uniprot/P21279.txt?version=168

1 reference

9 November 2015

http://www.uniprot.org/uniprot/P21279.txt?version=168

1 reference

based on heuristic

inferred by common MeSH mappings on source and on Wikidata

25 May 2023

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