RAP2B, member of RAS oncogene family (Q21113507)

http://www.ebi.ac.uk/interpro/protein/P61225

P-loop containing nucleoside triphosphate hydrolase

1 reference

stated in

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P61225

Small GTP-binding protein domain family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

1 reference

13 November 2019

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61225

protein domain specific binding

IEA

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61225

1 reference

8 April 2019

Identification and biochemical characterization of Rap2C, a new member of the Rap family of small GTP-binding proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61225

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61225

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61225

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61225

8 April 2019

Targeting of the small GTPase Rap2b, but not Rap1b, to lipid rafts is promoted by palmitoylation at Cys176 and Cys177 and is required for efficient protein activation in human platelets

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61225

8 April 2019

Identification and biochemical characterization of Rap2C, a new member of the Rap family of small GTP-binding proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61225

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61225

6 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61225

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61225

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61225

9 May 2019

Identification and biochemical characterization of Rap2C, a new member of the Rap family of small GTP-binding proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61225

9 May 2019

Targeting of the small GTPase Rap2b, but not Rap1b, to lipid rafts is promoted by palmitoylation at Cys176 and Cys177 and is required for efficient protein activation in human platelets

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61225

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61225

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61225

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61225

4 references

9 May 2019

Targeting of the small GTPase Rap2b, but not Rap1b, to lipid rafts is promoted by palmitoylation at Cys176 and Cys177 and is required for efficient protein activation in human platelets

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61225

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61225

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61225

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61225

JAM-A associates with ZO-2, afadin, and PDZ-GEF1 to activate Rap2c and regulate epithelial barrier function

IEA

cell-cell contact zone

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61225

bicellular tight junction

1 reference

9 May 2019

JAM-A associates with ZO-2, afadin, and PDZ-GEF1 to activate Rap2c and regulate epithelial barrier function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61225

recycling endosome membrane

1 reference

9 May 2019

Targeting of the small GTPase Rap2b, but not Rap1b, to lipid rafts is promoted by palmitoylation at Cys176 and Cys177 and is required for efficient protein activation in human platelets

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61225

Rap2, but not Rap1 GTPase is expressed in human red blood cells and is involved in vesiculation

IMP

extracellular exosome

3 references

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P61225&geneProductId=UniProtKB:P61225

26 September 2017

Large-scale proteomics and phosphoproteomics of urinary exosomes

http://www.ebi.ac.uk/QuickGO/annotations?protein=P61225&geneProductId=UniProtKB:P61225

26 September 2017

MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis

http://www.ebi.ac.uk/QuickGO/annotations?protein=P61225&geneProductId=UniProtKB:P61225

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61225

8 April 2019

Rap2, but not Rap1 GTPase is expressed in human red blood cells and is involved in vesiculation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61225

8 April 2019

Identification and biochemical characterization of Rap2C, a new member of the Rap family of small GTP-binding proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61225

specific granule membrane

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61225

tertiary granule membrane

TAS

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61225

Rap2, but not Rap1 GTPase is expressed in human red blood cells and is involved in vesiculation

TAS

extracellular exosome

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61225

9 May 2019

MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61225

9 May 2019

Large-scale proteomics and phosphoproteomics of urinary exosomes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61225

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61225

9 May 2019

Identification and biochemical characterization of Rap2C, a new member of the Rap family of small GTP-binding proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61225

9 May 2019

Rap2, but not Rap1 GTPase is expressed in human red blood cells and is involved in vesiculation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61225

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61225

1 reference

9 May 2019

Rap2A links intestinal cell polarity to brush border formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61225

establishment of endothelial intestinal barrier

IMP

1 reference

9 May 2019

JAM-A associates with ZO-2, afadin, and PDZ-GEF1 to activate Rap2c and regulate epithelial barrier function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61225

1 reference

9 May 2019

Targeting of the small GTPase Rap2b, but not Rap1b, to lipid rafts is promoted by palmitoylation at Cys176 and Cys177 and is required for efficient protein activation in human platelets

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61225

negative regulation of cell migration

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61225

positive regulation of protein autophosphorylation

IEA

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61225

1 reference

9 May 2019

Targeting of the small GTPase Rap2b, but not Rap1b, to lipid rafts is promoted by palmitoylation at Cys176 and Cys177 and is required for efficient protein activation in human platelets

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61225

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61225

neutrophil degranulation

1 reference

9 May 2019

Rap protein signal transduction

TAS

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61225

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61225

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61225

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61225

small GTP-binding protein domain

IBA

has part(s)

1 reference

stated in

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P61225

Identifiers

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

20 March 2016

1 reference

20 March 2016

1 reference

20 March 2016

1 reference

20 March 2016