ADAM metallopeptidase domain 15 (Q21113814)

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mammalian protein found in Homo sapiens

MDC-15
metalloprotease RGD disintegrin protein
Metargidin
metalloproteinase-like, disintegrin-like, and cysteine-rich protein 15
ADAM15
disintegrin and metalloproteinase domain-containing protein 15
a disintegrin and metalloproteinase domain 15 (metargidin)

Language	Label	Description	Also known as
English	ADAM metallopeptidase domain 15	mammalian protein found in Homo sapiens	MDC-15 metalloprotease RGD disintegrin protein Metargidin metalloproteinase-like, disintegrin-like, and cysteine-rich protein 15 ADAM15 disintegrin and metalloproteinase domain-containing protein 15 a disintegrin and metalloproteinase domain 15 (metargidin)

Statements

1 reference

13 November 2019

UniProt protein ID

ADAM15 peptidase

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q13444

disintegrin domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q13444

Metallopeptidase, catalytic domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q13444

Peptidase M12B, ADAM/reprolysin, protein family

1 reference

based on heuristic

inferred from protein domain or family

Reprolysin domain, adamalysin-type, protein family

1 reference

based on heuristic

inferred from protein domain or family

ADAM, cysteine-rich, protein family

1 reference

based on heuristic

inferred from protein domain or family

Disintegrin domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

EGF-like domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

EGF-like, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

Peptidase M12B, propeptide family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

metal ion binding

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13444

determination method

integrin binding

determination method

1 reference

8 April 2019

Exosome release of ADAM15 and the functional implications of human macrophage-derived ADAM15 exosomes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13444

determination method

peptidase activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13444

determination method

protein binding

determination method

5 references

8 April 2019

Interaction of the metalloprotease disintegrins MDC9 and MDC15 with two SH3 domain-containing proteins, endophilin I and SH3PX1

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13444

determination method

8 April 2019

Identification of preferred protein interactions by phage-display of the human Src homology-3 proteome

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13444

determination method

8 April 2019

Phosphorylation-dependent interactions between ADAM15 cytoplasmic domain and Src family protein-tyrosine kinases

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13444

determination method

8 April 2019

A proteome-scale map of the human interactome network

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13444

determination method

8 April 2019

ADAM binding protein Eve-1 is required for ectodomain shedding of epidermal growth factor receptor ligands

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13444

determination method

hydrolase activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13444

determination method

metallopeptidase activity

determination method

4 references

8 April 2019

Specific interaction of the recombinant disintegrin-like domain of MDC-15 (metargidin, ADAM-15) with integrin alphavbeta3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13444

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13444

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13444

determination method

8 April 2019

Catalytic activity of ADAM8, ADAM15, and MDC-L (ADAM28) on synthetic peptide substrates and in ectodomain cleavage of CD23

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13444

determination method

metalloendopeptidase activity

determination method

2 references

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13444&geneProductId=UniProtKB:Q13444

determination method

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13444&geneProductId=UniProtKB:Q13444

determination method

metalloendopeptidase activity

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13444

determination method

integral component of membrane

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13444

determination method

cell projection

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13444

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13444

determination method

adherens junction

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13444

determination method

plasma membrane

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13444

determination method

determination method

1 reference

8 April 2019

Exosome release of ADAM15 and the functional implications of human macrophage-derived ADAM15 exosomes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13444

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13444

determination method

acrosomal vesicle

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13444

determination method

extracellular exosome

determination method

1 reference

8 April 2019

Exosome release of ADAM15 and the functional implications of human macrophage-derived ADAM15 exosomes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13444

determination method

cytoplasmic vesicle

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13444

determination method

endomembrane system

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13444

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13444

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13444

determination method

biological process

male gonad development

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13444

determination method

negative regulation of receptor binding

determination method

1 reference

8 April 2019

Exosome release of ADAM15 and the functional implications of human macrophage-derived ADAM15 exosomes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13444

determination method

tissue regeneration

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13444

determination method

extracellular matrix disassembly

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13444

determination method

determination method

2 references

negative regulation of cell-matrix adhesion

determination method

1 reference

8 April 2019

Exosome release of ADAM15 and the functional implications of human macrophage-derived ADAM15 exosomes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13444

determination method

negative regulation of cell migration

determination method

1 reference

8 April 2019

Exosome release of ADAM15 and the functional implications of human macrophage-derived ADAM15 exosomes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13444

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13444

determination method

negative regulation of cell growth

determination method

1 reference

8 April 2019

Exosome release of ADAM15 and the functional implications of human macrophage-derived ADAM15 exosomes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13444

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13444

determination method

collagen catabolic process

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13444

determination method

integrin-mediated signaling pathway

determination method

1 reference

8 April 2019

Exosome release of ADAM15 and the functional implications of human macrophage-derived ADAM15 exosomes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13444

determination method

cell-matrix adhesion

determination method

1 reference

8 April 2019

Specific interaction of the recombinant disintegrin-like domain of MDC-15 (metargidin, ADAM-15) with integrin alphavbeta3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13444

determination method

innate immune response

determination method

1 reference

8 April 2019

Exosome release of ADAM15 and the functional implications of human macrophage-derived ADAM15 exosomes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13444

determination method

cardiac epithelial to mesenchymal transition

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13444

determination method

apoptotic process

determination method

1 reference

8 April 2019

Exosome release of ADAM15 and the functional implications of human macrophage-derived ADAM15 exosomes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13444

determination method

extracellular matrix organization

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13444

determination method

immune response to tumor cell

determination method

1 reference

8 April 2019

Exosome release of ADAM15 and the functional implications of human macrophage-derived ADAM15 exosomes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13444

determination method

cellular response to phorbol 13-acetate 12-myristate

determination method

1 reference

8 April 2019

Exosome release of ADAM15 and the functional implications of human macrophage-derived ADAM15 exosomes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13444

determination method

response to hypobaric hypoxia

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13444

determination method

EGF-like, conserved site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q13444

Peptidase M12B, propeptide

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q13444

Peptidase M12B, ADAM/reprolysin

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q13444

Disintegrin domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q13444

ADAM, cysteine-rich

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q13444

EGF-like domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q13444

Reprolysin domain, adamalysin-type

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q13444

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000271836

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000271836

ENSP00000348227

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000348227

ENSP00000349436

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000349436

ENSP00000352226

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000352226

ENSP00000353892

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000353892

ENSP00000357397

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000357397

ENSP00000357398

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000357398

ENSP00000403843

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000403843

ENSP00000432347

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000432347

ENSP00000432927

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000432927

ENSP00000434227

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000434227

ENSP00000476000

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000476000

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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