Glucosylceramidase beta 3 (gene/pseudogene) (Q21114568)

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mammalian protein found in Homo sapiens

glucosidase beta acid 3
klotho-related protein
cytosolic glycosylceramidase
cytosolic beta-glucosidase-like protein 1
cytosolic GCase
cytosolic beta-glucosidase
glucosidase, beta, acid 3 (cytosolic)
GBA3

Language	Label	Description	Also known as
English	Glucosylceramidase beta 3 (gene/pseudogene)	mammalian protein found in Homo sapiens	glucosidase beta acid 3 klotho-related protein cytosolic glycosylceramidase cytosolic beta-glucosidase-like protein 1 cytosolic GCase cytosolic beta-glucosidase glucosidase, beta, acid 3 (cytosolic) GBA3

Statements

1 reference

13 November 2019

UniProt protein ID

glycoside hydrolase superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9H227

Glycoside hydrolase family 1

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9H227

Glycosyl hydrolases family 1, N-terminal conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

beta-galactosidase activity

determination method

3 references

27 March 2018

Klotho-related protein is a novel cytosolic neutral beta-glycosylceramidase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9H227&geneProductId=UniProtKB:Q9H227

determination method

27 March 2018

Cloning and characterization of human liver cytosolic beta-glycosidase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9H227&geneProductId=UniProtKB:Q9H227

determination method

27 March 2018

Co-Expression of NEU2 and GBA3 Causes a Drastic Reduction in Cytosolic Sialyl Free N-glycans in Human MKN45 Stomach Cancer Cells-Evidence for the Physical Interaction of NEU2 and GBA3

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9H227&geneProductId=UniProtKB:Q9H227

determination method

glycosylceramidase activity

determination method

1 reference

27 March 2018

Klotho-related protein is a novel cytosolic neutral beta-glycosylceramidase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9H227&geneProductId=UniProtKB:Q9H227

determination method

hydrolase activity, hydrolyzing O-glycosyl compounds

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H227

determination method

beta-glucosidase activity

determination method

3 references

27 March 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9H227&geneProductId=UniProtKB:Q9H227

determination method

27 March 2018

Klotho-related protein is a novel cytosolic neutral beta-glycosylceramidase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9H227&geneProductId=UniProtKB:Q9H227

determination method

27 March 2018

Co-Expression of NEU2 and GBA3 Causes a Drastic Reduction in Cytosolic Sialyl Free N-glycans in Human MKN45 Stomach Cancer Cells-Evidence for the Physical Interaction of NEU2 and GBA3

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9H227&geneProductId=UniProtKB:Q9H227

determination method

hydrolase activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H227

determination method

hydrolase activity, acting on glycosyl bonds

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H227

determination method

scopolin beta-glucosidase activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H227

determination method

glucosylceramidase activity

determination method

1 reference

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9H227&geneProductId=UniProtKB:Q9H227

determination method

protein binding

determination method

1 reference

8 April 2019

Co-Expression of NEU2 and GBA3 Causes a Drastic Reduction in Cytosolic Sialyl Free N-glycans in Human MKN45 Stomach Cancer Cells-Evidence for the Physical Interaction of NEU2 and GBA3

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H227

determination method

beta-galactosidase activity

determination method

4 references

8 April 2019

Cloning and characterization of human liver cytosolic beta-glycosidase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H227

determination method

8 April 2019

Klotho-related protein is a novel cytosolic neutral beta-glycosylceramidase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H227

determination method

8 April 2019

Co-Expression of NEU2 and GBA3 Causes a Drastic Reduction in Cytosolic Sialyl Free N-glycans in Human MKN45 Stomach Cancer Cells-Evidence for the Physical Interaction of NEU2 and GBA3

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H227

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H227

determination method

beta-glucosidase activity

determination method

6 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H227

determination method

8 April 2019

Klotho-related protein is a novel cytosolic neutral beta-glycosylceramidase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H227

determination method

8 April 2019

The cytosolic β-glucosidase GBA3 does not influence type 1 Gaucher disease manifestation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H227

determination method

8 April 2019

Functional expression of human liver cytosolic beta-glucosidase in Pichia pastoris. Insights into its role in the metabolism of dietary glucosides

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H227

determination method

8 April 2019

Co-Expression of NEU2 and GBA3 Causes a Drastic Reduction in Cytosolic Sialyl Free N-glycans in Human MKN45 Stomach Cancer Cells-Evidence for the Physical Interaction of NEU2 and GBA3

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H227

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H227

determination method

galactosylceramidase activity

determination method

1 reference

8 April 2019

Klotho-related protein is a novel cytosolic neutral beta-glycosylceramidase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H227

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H227

determination method

determination method

4 references

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9H227&geneProductId=UniProtKB:Q9H227

determination method

27 March 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9H227&geneProductId=UniProtKB:Q9H227

determination method

27 March 2018

Klotho-related protein is a novel cytosolic neutral beta-glycosylceramidase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9H227&geneProductId=UniProtKB:Q9H227

determination method

27 March 2018

Co-Expression of NEU2 and GBA3 Causes a Drastic Reduction in Cytosolic Sialyl Free N-glycans in Human MKN45 Stomach Cancer Cells-Evidence for the Physical Interaction of NEU2 and GBA3

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9H227&geneProductId=UniProtKB:Q9H227

determination method

catalytic complex

determination method

1 reference

8 April 2019

Co-Expression of NEU2 and GBA3 Causes a Drastic Reduction in Cytosolic Sialyl Free N-glycans in Human MKN45 Stomach Cancer Cells-Evidence for the Physical Interaction of NEU2 and GBA3

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H227

determination method

determination method

6 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H227

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H227

determination method

8 April 2019

The cytosolic β-glucosidase GBA3 does not influence type 1 Gaucher disease manifestation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H227

determination method

8 April 2019

Klotho-related protein is a novel cytosolic neutral beta-glycosylceramidase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H227

determination method

8 April 2019

Co-Expression of NEU2 and GBA3 Causes a Drastic Reduction in Cytosolic Sialyl Free N-glycans in Human MKN45 Stomach Cancer Cells-Evidence for the Physical Interaction of NEU2 and GBA3

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H227

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H227

determination method

biological process

glycosylceramide catabolic process

determination method

1 reference

27 March 2018

Klotho-related protein is a novel cytosolic neutral beta-glycosylceramidase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9H227&geneProductId=UniProtKB:Q9H227

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H227

determination method

glycosphingolipid metabolic process

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H227

determination method

glycoside catabolic process

determination method

1 reference

8 April 2019

Cloning and characterization of human liver cytosolic beta-glycosidase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H227

determination method

protein stabilization

determination method

1 reference

8 April 2019

Co-Expression of NEU2 and GBA3 Causes a Drastic Reduction in Cytosolic Sialyl Free N-glycans in Human MKN45 Stomach Cancer Cells-Evidence for the Physical Interaction of NEU2 and GBA3

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H227

determination method

cellular oligosaccharide catabolic process

determination method

1 reference

8 April 2019

Co-Expression of NEU2 and GBA3 Causes a Drastic Reduction in Cytosolic Sialyl Free N-glycans in Human MKN45 Stomach Cancer Cells-Evidence for the Physical Interaction of NEU2 and GBA3

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H227

determination method

positive regulation of exo-alpha-sialidase activity

determination method

1 reference

8 April 2019

Co-Expression of NEU2 and GBA3 Causes a Drastic Reduction in Cytosolic Sialyl Free N-glycans in Human MKN45 Stomach Cancer Cells-Evidence for the Physical Interaction of NEU2 and GBA3

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H227

determination method

carbohydrate metabolic process

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H227

determination method

glucosylceramide catabolic process

determination method

3 references

8 April 2019

Klotho-related protein is a novel cytosolic neutral beta-glycosylceramidase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H227

determination method

8 April 2019

The cytosolic β-glucosidase GBA3 does not influence type 1 Gaucher disease manifestation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H227

determination method

8 April 2019

Glucosylated cholesterol in mammalian cells and tissues: formation and degradation by multiple cellular β-glucosidases

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H227

determination method

galactosylceramide catabolic process

determination method

1 reference

8 April 2019

Klotho-related protein is a novel cytosolic neutral beta-glycosylceramidase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H227

determination method

glycosylceramide catabolic process

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H227

determination method

beta-glucoside catabolic process

determination method

1 reference

8 April 2019

Functional expression of human liver cytosolic beta-glucosidase in Pichia pastoris. Insights into its role in the metabolism of dietary glucosides

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H227

determination method

Glycosyl hydrolases family 1, N-terminal conserved site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9H227

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000422220

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000422220

ENSP00000423754

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000423754

ENSP00000427458

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000427458

ENSP00000478226

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000478226

ENSP00000480447

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000480447

PDB structure ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

Sitelinks

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