Ring finger protein 5 (Q21116213)

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mammalian protein found in Homo sapiens

RING finger protein 5
ring finger protein 5, E3 ubiquitin protein ligase
HsRma1
RING-type E3 ubiquitin transferase RNF5
E3 ubiquitin-protein ligase RNF5
RNF5
ram1 homolog
protein G16

Language	Label	Description	Also known as
English	Ring finger protein 5	mammalian protein found in Homo sapiens	RING finger protein 5 ring finger protein 5, E3 ubiquitin protein ligase HsRma1 RING-type E3 ubiquitin transferase RNF5 E3 ubiquitin-protein ligase RNF5 RNF5 ram1 homolog protein G16

Statements

1 reference

13 November 2019

UniProt protein ID

Zinc finger, RING/FYVE/PHD-type

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q99942

Zinc finger, RING-type, protein family

1 reference

based on heuristic

inferred from protein domain or family

Zinc finger, RING-type, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

metal ion binding

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99942

determination method

ubiquitin-protein transferase activity

determination method

1 reference

9 May 2019

Regulation of endoplasmic reticulum-associated degradation by RNF5-dependent ubiquitination of JNK-associated membrane protein (JAMP)

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99942

determination method

protein binding

determination method

9 references

9 May 2019

Regulation of endoplasmic reticulum-associated degradation by RNF5-dependent ubiquitination of JNK-associated membrane protein (JAMP)

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99942

determination method

9 May 2019

RNF185 is a novel E3 ligase of endoplasmic reticulum-associated degradation (ERAD) that targets cystic fibrosis transmembrane conductance regulator (CFTR)

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99942

determination method

9 May 2019

Regulation of glutamine carrier proteins by RNF5 determines breast cancer response to ER stress-inducing chemotherapies

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99942

determination method

9 May 2019

Analysis of the human E2 ubiquitin conjugating enzyme protein interaction network

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99942

determination method

9 May 2019

Sequential quality-control checkpoints triage misfolded cystic fibrosis transmembrane conductance regulator

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99942

determination method

9 May 2019

Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99942

determination method

9 May 2019

Crystal structure of UbcH5b~ubiquitin intermediate: insight into the formation of the self-assembled E2~Ub conjugates

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99942

determination method

9 May 2019

A proteome-scale map of the human interactome network

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99942

determination method

9 May 2019

RNF5, a RING finger protein that regulates cell motility by targeting paxillin ubiquitination and altered localization

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99942

determination method

ubiquitin-like protein conjugating enzyme binding

determination method

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99942

determination method

transferase activity

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99942

determination method

identical protein binding

determination method

1 reference

9 May 2019

A proteome-scale map of the human interactome network

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99942

determination method

zinc ion binding

determination method

1 reference

9 May 2019

Cloning, expression and mapping of a novel RING-finger gene (RNF5), a human homologue of a putative zinc-finger gene from Caenorhabditis elegans

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99942

determination method

ubiquitin protein ligase activity

determination method

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99942

determination method

9 May 2019

RNF185 is a novel E3 ligase of endoplasmic reticulum-associated degradation (ERAD) that targets cystic fibrosis transmembrane conductance regulator (CFTR)

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99942

determination method

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99942

determination method

protein-containing complex binding

determination method

1 reference

9 May 2019

RNF185 is a novel E3 ligase of endoplasmic reticulum-associated degradation (ERAD) that targets cystic fibrosis transmembrane conductance regulator (CFTR)

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99942

determination method

integral component of membrane

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99942

determination method

mitochondrial membranes

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99942

determination method

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99942

determination method

Derlin-1 retrotranslocation complex

determination method

1 reference

21 June 2018

RNF185 is a novel E3 ligase of endoplasmic reticulum-associated degradation (ERAD) that targets cystic fibrosis transmembrane conductance regulator (CFTR)

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99942&geneProductId=UniProtKB:Q99942

determination method

endoplasmic reticulum quality control compartment

determination method

1 reference

9 May 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99942

determination method

Derlin-1 retrotranslocation complex

determination method

Derlin-1 retrotranslocation complex

determination method

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99942

determination method

biological process

response to bacterium

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99942

determination method

protein K63-linked ubiquitination

determination method

1 reference

9 May 2019

Regulation of endoplasmic reticulum-associated degradation by RNF5-dependent ubiquitination of JNK-associated membrane protein (JAMP)

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99942

determination method

ER-associated misfolded protein catabolic process

determination method

1 reference

21 June 2018

Regulation of endoplasmic reticulum-associated degradation by RNF5-dependent ubiquitination of JNK-associated membrane protein (JAMP)

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99942&geneProductId=UniProtKB:Q99942

determination method

regulation of autophagosome assembly

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99942

determination method

protein K48-linked ubiquitination

determination method

1 reference

9 May 2019

The ubiquitin ligase RNF5 regulates antiviral responses by mediating degradation of the adaptor protein MITA

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99942

determination method

protein destabilization

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99942

determination method

negative regulation of autophagy

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99942

determination method

transmembrane transport

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99942

determination method

endoplasmic reticulum mannose trimming

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99942

determination method

ubiquitin-dependent ERAD pathway

determination method

1 reference

9 May 2019

RNF185 is a novel E3 ligase of endoplasmic reticulum-associated degradation (ERAD) that targets cystic fibrosis transmembrane conductance regulator (CFTR)

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99942

determination method

determination method

1 reference

9 May 2019

RNF185 is a novel E3 ligase of endoplasmic reticulum-associated degradation (ERAD) that targets cystic fibrosis transmembrane conductance regulator (CFTR)

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99942

determination method

ubiquitin-dependent protein catabolic process

determination method

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99942

determination method

ER-associated misfolded protein catabolic process

determination method

Zinc finger, RING-type, conserved site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q99942

Zinc finger, RING-type

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q99942

Identifiers

RefSeq protein ID

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000364235

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000364235

ENSP00000387879

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000387879

ENSP00000388795

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000388795

ENSP00000401172

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000401172

ENSP00000413131

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000413131

ENSP00000415127

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000415127

ENSP00000415784

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000415784

ENSP00000434880

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000434880

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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