BAR/IMD domain containing adaptor protein 2 (Q21171687)

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mammalian protein found in Homo sapiens
  • IRSp53
  • insulin receptor substrate protein of 53 kDa
  • insulin receptor substrate p53/p58
  • fas ligand-associated factor 3
  • IRSp53/58
  • FLAF3
  • brain-specific angiogenesis inhibitor 1-associated protein 2
  • insulin receptor substrate of 53 kDa
  • BAIAP2
  • IRS-58
  • BAI1 associated protein 2
  • Insulin receptor substrate p53
  • WASP and MIM like
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Language Label Description Also known as
English
BAR/IMD domain containing adaptor protein 2
mammalian protein found in Homo sapiens
  • IRSp53
  • insulin receptor substrate protein of 53 kDa
  • insulin receptor substrate p53/p58
  • fas ligand-associated factor 3
  • IRSp53/58
  • FLAF3
  • brain-specific angiogenesis inhibitor 1-associated protein 2
  • insulin receptor substrate of 53 kDa
  • BAIAP2
  • IRS-58
  • BAI1 associated protein 2
  • Insulin receptor substrate p53
  • WASP and MIM like

Statements

molecular function
protein binding
determination method
IPI
15 references
retrieved
8 April 2019
stated in
Novel espin actin-bundling proteins are localized to Purkinje cell dendritic spines and bind the Src homology 3 adapter protein insulin receptor substrate p53
GOA
curator
UniProt
UniProt protein ID
Q9UQB8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UQB8
determination method
IPI
retrieved
8 April 2019
stated in
Eps8 regulates axonal filopodia in hippocampal neurons in response to brain-derived neurotrophic factor (BDNF)
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UQB8
determination method
IPI
retrieved
8 April 2019
stated in
The EHEC-host interactome reveals novel targets for the translocated intimin receptor
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UQB8
determination method
IPI
retrieved
8 April 2019
stated in
Phospho-tyrosine dependent protein-protein interaction network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UQB8
determination method
IPI
retrieved
8 April 2019
stated in
Cdc42Hs facilitates cytoskeletal reorganization and neurite outgrowth by localizing the 58-kD insulin receptor substrate to filamentous actin
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UQB8
determination method
IPI
retrieved
8 April 2019
stated in
Cdc42 induces filopodia by promoting the formation of an IRSp53:Mena complex
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UQB8
determination method
IPI
retrieved
8 April 2019
stated in
The RAC binding domain/IRSp53-MIM homology domain of IRSp53 induces RAC-dependent membrane deformation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UQB8
determination method
IPI
retrieved
8 April 2019
stated in
A proteome-scale map of the human interactome network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UQB8
determination method
IPI
retrieved
8 April 2019
stated in
Towards a proteome-scale map of the human protein–protein interaction network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UQB8
determination method
IPI
retrieved
8 April 2019
stated in
SPIN90-IRSp53 complex participates in Rac-induced membrane ruffling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UQB8
determination method
IPI
retrieved
8 April 2019
stated in
A human MAP kinase interactome
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UQB8
determination method
IPI
retrieved
8 April 2019
stated in
Rho GTPase Cdc42 is a direct interacting partner of Adenomatous Polyposis Coli protein and can alter its cellular localization
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UQB8
determination method
IPI
retrieved
8 April 2019
stated in
Kank attenuates actin remodeling by preventing interaction between IRSp53 and Rac1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UQB8
determination method
IPI
retrieved
8 April 2019
stated in
IRSp53/Eps8 complex is important for positive regulation of Rac and cancer cell motility/invasiveness
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UQB8
determination method
IPI
retrieved
8 April 2019
stated in
The Cdc42 effector IRSp53 generates filopodia by coupling membrane protrusion with actin dynamics
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UQB8
determination method
IPI
cell component
biological process

Identifiers

RefSeq protein ID
Ensembl protein ID
 
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