Glutamate-cysteine ligase, catalytic subunit (Q21985414)

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mammalian protein found in Mus musculus
  • gamma-glutamylcysteine synthetase heavy subunit
  • gamma GCS-HS
  • Gamma-glutamylcysteine synthetase
  • glutamate--cysteine ligase catalytic subunit
  • gamma-ECS
  • GCS heavy chain
  • Gclc
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Language Label Description Also known as
English
Glutamate-cysteine ligase, catalytic subunit
mammalian protein found in Mus musculus
  • gamma-glutamylcysteine synthetase heavy subunit
  • gamma GCS-HS
  • Gamma-glutamylcysteine synthetase
  • glutamate--cysteine ligase catalytic subunit
  • gamma-ECS
  • GCS heavy chain
  • Gclc

Statements

molecular function
glutamate-cysteine ligase activity
determination method
IDA
ISS
IEA
IMP
ISO
10 references
retrieved
24 April 2018
stated in
GOA
curator
UniProt
UniProt protein ID
P97494
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P97494&geneProductId=UniProtKB:P97494
determination method
ISS
retrieved
24 April 2018
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P97494&geneProductId=UniProtKB:P97494
determination method
ISO
retrieved
24 April 2018
stated in
Knockout of the mouse glutamate cysteine ligase catalytic subunit (Gclc) gene: embryonic lethal when homozygous, and proposed model for moderate glutathione deficiency when heterozygous
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P97494&geneProductId=UniProtKB:P97494
determination method
IMP
retrieved
24 April 2018
stated in
GOA
curator
UniProt
UniProt protein ID
P97494
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P97494&geneProductId=UniProtKB:P97494
determination method
IEA
retrieved
24 April 2018
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P97494&geneProductId=UniProtKB:P97494
determination method
IEA
retrieved
24 April 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P97494&geneProductId=UniProtKB:P97494
determination method
IEA
retrieved
24 April 2018
stated in
Glutamate-cysteine ligase attenuates TNF-induced mitochondrial injury and apoptosis
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P97494&geneProductId=UniProtKB:P97494
determination method
IDA
retrieved
24 April 2018
stated in
Initial characterization of the glutamate-cysteine ligase modifier subunit Gclm(-/-) knockout mouse. Novel model system for a severely compromised oxidative stress response
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P97494&geneProductId=UniProtKB:P97494
determination method
IDA
retrieved
24 April 2018
stated in
Modulation of glutathione and glutamate-L-cysteine ligase by methylmercury during mouse development
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P97494&geneProductId=UniProtKB:P97494
determination method
IDA
retrieved
24 April 2018
stated in
Glutamate cysteine ligase catalysis: dependence on ATP and modifier subunit for regulation of tissue glutathione levels
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P97494&geneProductId=UniProtKB:P97494
determination method
IDA
glutamate-cysteine ligase activity
determination method
IBA
IDA
IEA
IMP
ISO
ISS
11 references
retrieved
14 February 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P97494
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97494
determination method
ISS
retrieved
14 February 2019
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97494
determination method
ISO
retrieved
14 February 2019
stated in
Knockout of the mouse glutamate cysteine ligase catalytic subunit (Gclc) gene: embryonic lethal when homozygous, and proposed model for moderate glutathione deficiency when heterozygous
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97494
determination method
IMP
retrieved
14 February 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P97494
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97494
determination method
IEA
retrieved
14 February 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97494
determination method
IEA
retrieved
14 February 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97494
determination method
IEA
retrieved
14 February 2019
stated in
Glutamate-cysteine ligase attenuates TNF-induced mitochondrial injury and apoptosis
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97494
determination method
IDA
retrieved
14 February 2019
stated in
Initial characterization of the glutamate-cysteine ligase modifier subunit Gclm(-/-) knockout mouse. Novel model system for a severely compromised oxidative stress response
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97494
determination method
IDA
retrieved
14 February 2019
stated in
Glutamate cysteine ligase catalysis: dependence on ATP and modifier subunit for regulation of tissue glutathione levels
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97494
determination method
IDA
retrieved
14 February 2019
stated in
Modulation of glutathione and glutamate-L-cysteine ligase by methylmercury during mouse development
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97494
determination method
IDA
retrieved
14 February 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97494
determination method
IBA
cell component
biological process
glutathione biosynthetic process
determination method
IDA
ISS
IEA
IMP
ISO
7 references
retrieved
24 April 2018
stated in
GOA
curator
UniProt
UniProt protein ID
P97494
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P97494&geneProductId=UniProtKB:P97494
determination method
ISS
retrieved
24 April 2018
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P97494&geneProductId=UniProtKB:P97494
determination method
ISO
retrieved
24 April 2018
stated in
Glutathione synthesis is essential for mouse development but not for cell growth in culture
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P97494&geneProductId=UniProtKB:P97494
determination method
IMP
retrieved
24 April 2018
stated in
GOA
curator
UniProt
UniProt protein ID
P97494
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P97494&geneProductId=UniProtKB:P97494
determination method
IEA
retrieved
24 April 2018
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P97494&geneProductId=UniProtKB:P97494
determination method
IEA
retrieved
24 April 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P97494&geneProductId=UniProtKB:P97494
determination method
IEA
retrieved
24 April 2018
stated in
Glutamate cysteine ligase catalysis: dependence on ATP and modifier subunit for regulation of tissue glutathione levels
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P97494&geneProductId=UniProtKB:P97494
determination method
IDA
glutathione biosynthetic process
determination method
IBA
IDA
IEA
IMP
ISO
ISS
8 references
retrieved
14 February 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P97494
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97494
determination method
ISS
retrieved
14 February 2019
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97494
determination method
ISO
retrieved
14 February 2019
stated in
Glutathione synthesis is essential for mouse development but not for cell growth in culture
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97494
determination method
IMP
retrieved
14 February 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P97494
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97494
determination method
IEA
retrieved
14 February 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97494
determination method
IEA
retrieved
14 February 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97494
determination method
IEA
retrieved
14 February 2019
stated in
Glutamate cysteine ligase catalysis: dependence on ATP and modifier subunit for regulation of tissue glutathione levels
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97494
determination method
IDA
retrieved
14 February 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97494
determination method
IBA

Identifiers

 
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