SOCS-6 negatively regulates T cell activation through targeting p56lck to proteasomal degradation (Q22001519)

LCK proto-oncogene, Src family tyrosine kinase

1 reference

Suppressor of cytokine signaling 6

1 reference

Lymphocyte protein tyrosine kinase

1 reference

1 reference

Young Bong Choi

1

Young Bong

Choi

1 reference

7 February 2023

Myoungsun Son

2

Myoungsun

Son

1 reference

7 February 2023

Mijin Park

3

Mijin

Park

1 reference

7 February 2023

Jaekyoon Shin

4

Jaekyoon

Shin

1 reference

7 February 2023

Yungdae Yun

5

Yungdae

Yun

1 reference

Journal of Biological Chemistry

7 February 2023

language of work or name

English

0 references

publication date

5 March 2010

0 references

published in

0 references

volume

285

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issue

10

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page(s)

7271-80

0 references

cites work

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VHL-box and SOCS-box domains determine binding specificity for Cul2-Rbx1 and Cul5-Rbx2 modules of ubiquitin ligases

19 March 2017

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LIME, a novel transmembrane adaptor protein, associates with p56lck and mediates T cell activation

19 March 2017

1 reference

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The influence of the src-family kinases, Lck and Fyn, on T cell differentiation, survival and activation

19 March 2017

1 reference

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SOCS-6 binds to insulin receptor substrate 4, and mice lacking the SOCS-6 gene exhibit mild growth retardation

19 March 2017

1 reference

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Tyrosine phosphorylation-dependent yeast two-hybrid system for the identification of the SH2 domain-binding proteins

19 March 2017

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Lad, an adapter protein interacting with the SH2 domain of p56lck, is required for T cell activation

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2844175

The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation

19 March 2017

1 reference

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Twenty proteins containing a C-terminal SOCS box form five structural classes

19 March 2017

1 reference

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Cloning and characterization of novel CIS family genes

19 March 2017

1 reference

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A family of cytokine-inducible inhibitors of signalling

19 March 2017

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Regulation of Vav-SLP-76 binding by ZAP-70 and its relevance to TCR zeta/CD3 induction of interleukin-2

19 March 2017

1 reference

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A novel cytokine-inducible gene CIS encodes an SH2-containing protein that binds to tyrosine-phosphorylated interleukin 3 and erythropoietin receptors

19 March 2017

1 reference

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Sequential interactions of the TCR with two distinct cytoplasmic tyrosine kinases

19 March 2017

1 reference

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The human p50csk tyrosine kinase phosphorylates p56lck at Tyr-505 and down regulates its catalytic activity

19 March 2017

1 reference

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Structural basis for activation of human lymphocyte kinase Lck upon tyrosine phosphorylation

19 March 2017

1 reference

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A system for stable expression of short interfering RNAs in mammalian cells

19 March 2017

1 reference

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LIME acts as a transmembrane adapter mediating BCR-dependent B-cell activation

19 March 2017

1 reference

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Function of the Src-family kinases, Lck and Fyn, in T-cell development and activation

19 March 2017

1 reference

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The SOCS box: a tale of destruction and degradation

19 March 2017

1 reference

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Cutting edge: Suppressor of cytokine signaling 3 inhibits activation of NFATp

19 March 2017

1 reference

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Negative regulation of Lck by Cbl ubiquitin ligase

19 March 2017

1 reference

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Suppressors of cytokine signaling-1 and -6 associate with and inhibit the insulin receptor. A potential mechanism for cytokine-mediated insulin resistance

19 March 2017

1 reference

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LAT is required for TCR-mediated activation of PLCgamma1 and the Ras pathway

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2844175

The CD4 and CD8 T cell surface antigens are associated with the internal membrane tyrosine-protein kinase p56lck

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2844175

Structure and function of a new STAT-induced STAT inhibitor

19 March 2017

1 reference

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Ubiquitin-dependent c-Jun degradation in vivo is mediated by the delta domain

19 March 2017

1 reference

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E3 ubiquitin ligases as T cell anergy factors.

7 April 2017

1 reference

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Regulation of the Src family kinase Lck by Hsp90 and ubiquitination

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2844175

Altered lipid raft-associated signaling and ganglioside expression in T lymphocytes from patients with systemic lupus erythematosus

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2844175

Suppressors of cytokine signaling and immunity

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2844175

Suppressor of cytokine signaling 3 regulates proliferation and activation of T-helper cells

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2844175

The Lck SH3 domain negatively regulates localization to lipid rafts through an interaction with c-Cbl

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2844175

Hsp90 is essential for the synthesis and subsequent membrane association, but not the maintenance, of the Src-kinase p56(lck).

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2844175

Suppressors of cytokine signaling (SOCS): negative regulators of signal transduction.

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2844175

The Elongin BC complex interacts with the conserved SOCS-box motif present in members of the SOCS, ras, WD-40 repeat, and ankyrin repeat families

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2844175

The role of the linker between the SH2 domain and catalytic domain in the regulation and function of Src.

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2844175

The SH2 domain is required for stable phosphorylation of p56lck at tyrosine 505, the negative regulatory site

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2844175

Rapid activation of the T-cell tyrosine protein kinase pp56lck by the CD45 phosphotyrosine phosphatase

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2844175

Molecular interactions, T-cell subsets and a role of the CD4/CD8:p56lck complex in human T-cell activation

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2844175

CD4 enhances T cell sensitivity to antigen by coordinating Lck accumulation at the immunological synapse

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2844175

Lck activity controls CD4/CD8 T cell lineage commitment.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2844175

Regulation of Lck activity by CD4 and CD28 in the immunological synapse

30 May 2018

1 reference

Crossref

https://api.crossref.org/works/10.1074%2FJBC.M109.073726

Insulin induces SOCS-6 expression and its binding to the p85 monomer of phosphoinositide 3-kinase, resulting in improvement in glucose metabolism.

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1074%2FJBC.M109.073726

Increased ubiquitination and reduced expression of LCK in T lymphocytes from patients with systemic lupus erythematosus

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1074%2FJBC.M109.073726

Effects of geldanamycin, a heat-shock protein 90-binding agent, on T cell function and T cell nonreceptor protein tyrosine kinases

21 January 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/20007709

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Specific deficiency of p56lck expression in T lymphocytes from type 1 diabetic patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/20007709

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

T-cell activation is accompanied by an ubiquitination process occurring at the immunological synapse

1 reference

https://pubmed.ncbi.nlm.nih.gov/20007709

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1074/JBC.M109.073726

1 reference

1 reference

1 reference

1 reference