Tyrosine 319 in the interdomain B of ZAP-70 is a binding site for the Src homology 2 domain of Lck (Q22009540)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10318843%20AND%20SRC:MED&resulttype=core&format=json

7 December 2019

title

Tyrosine 319 in the interdomain B of ZAP-70 is a binding site for the Src homology 2 domain of Lck (English)

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7 December 2019

2

V Di Bartolo

V

Di Bartolo

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7 December 2019

5

J M Pascussi

J M

Pascussi

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7 December 2019

M Pelosi

1

M

Pelosi

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7 December 2019

V Mounier

3

V

Mounier

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7 December 2019

D Mège

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D

Mège

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7 December 2019

E Dufour

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E

Dufour

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7 December 2019

A Blondel

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A

Blondel

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7 December 2019

O Acuto

8

O

Acuto

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7 December 2019

language of work or name

English

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publication date

1 May 1999

1 reference

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Journal of Biological Chemistry

7 December 2019

published in

1 reference

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7 December 2019

volume

274

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7 December 2019

issue

20

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7 December 2019

page(s)

14229-14237

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The Syk family of protein tyrosine kinases in T-cell activation and development

7 December 2019

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Sequential interactions of the TCR with two distinct cytoplasmic tyrosine kinases

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Lck regulates the tyrosine phosphorylation of the T cell receptor subunits and ZAP-70 in murine thymocytes

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Molecular basis for interaction of the protein tyrosine kinase ZAP-70 with the T-cell receptor

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Binding of ZAP-70 to phosphorylated T-cell receptor zeta and eta enhances its autophosphorylation and generates specific binding sites for SH2 domain-containing proteins

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Activating and Inhibitory Mutations in Adjacent Tyrosines in the Kinase Domain of ZAP-70

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Mutation of tyrosines 492/493 in the kinase domain of ZAP-70 affects multiple T-cell receptor signaling pathways

21 January 2018

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p56lck interacts via its src homology 2 domain with the ZAP-70 kinase

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A novel phosphotyrosine-binding domain in the N-terminal transforming region of Cbl interacts directly and selectively with ZAP-70 in T cells

21 January 2018

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Tyrosine 474 of ZAP-70 is required for association with the Shc adaptor and for T-cell antigen receptor-dependent gene activation

21 January 2018

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Syk and ZAP-70 mediate recruitment of p56lck/CD4 to the activated T cell receptor/CD3/zeta complex

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SH2 domain function is essential for the role of the Lck tyrosine kinase in T cell receptor signal transduction

21 January 2018

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SH2 domains recognize specific phosphopeptide sequences

21 January 2018

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Recognition of a high-affinity phosphotyrosyl peptide by the Src homology-2 domain of p56lck

21 January 2018

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Tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis for the separation of proteins in the range from 1 to 100 kDa

21 January 2018

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The Vav binding site (Y315) in ZAP-70 is critical for antigen receptor-mediated signal transduction

21 January 2018

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Signal transmission between the plasma membrane and nucleus of T lymphocytes

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Dominant-negative zeta-associated protein 70 inhibits T cell antigen receptor signaling

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Tyrosine phosphorylation of focal adhesion kinase at sites in the catalytic domain regulates kinase activity: a role for Src family kinases

21 January 2018

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Autophosphorylation of the focal adhesion kinase, pp125FAK, directs SH2-dependent binding of pp60src

21 January 2018

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Lck phosphorylates the activation loop tyrosine of the Itk kinase domain and activates Itk kinase activity

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Regulation of Btk by Src family tyrosine kinases

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Distinct tyrosine phosphorylation sites in ZAP-70 mediate activation and negative regulation of antigen receptor function

21 January 2018

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Enhancement of lymphocyte responsiveness by a gain-of-function mutation of ZAP-70.

21 January 2018

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T cell activation induced by novel gain-of-function mutants of Syk and ZAP-70.

21 January 2018

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Sequence requirements for binding of Src family tyrosine kinases to activated growth factor receptors

21 January 2018

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Structure of the regulatory domains of the Src-family tyrosine kinase Lck

21 January 2018

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Crystal structure of the Src family tyrosine kinase Hck

21 January 2018

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Dynamics of Oxidation of a Fe2+-Bearing Aluminosilicate (Basaltic) Melt

21 January 2018

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Tyrosine 319, a newly identified phosphorylation site of ZAP-70, plays a critical role in T cell antigen receptor signaling

21 January 2018

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Anti-peptide antibodies detect conformational changes of the inter-SH2 domain of ZAP-70 due to binding to the zeta chain and to intramolecular interactions

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Purification and characterization of human ZAP-70 protein-tyrosine kinase from a baculovirus expression system

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Site specificity of p72 syk protein tyrosine kinase: efficient phosphorylation of motifs recognized by Src homology 2 domains of the Src family

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Reconstitution of T cell antigen receptor-induced Erk2 kinase activation in Lck-negative JCaM1 cells by Syk

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Role of Tyr518 and Tyr519 in the regulation of catalytic activity and substrate phosphorylation by Syk protein-tyrosine kinase

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The Syk protein tyrosine kinase can function independently of CD45 or Lck in T cell antigen receptor signaling

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