ZAP70: a master regulator of adaptive immunity (Q24298531)

zeta chain of T cell receptor associated protein kinase 70

Europe PubMed Central

title

ZAP70: a master regulator of adaptive immunity (English)

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main subject

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GOA release 2020-03-11

T cell migration

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GOA release 2020-03-11

author

Alain Fischer

1

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Capucine Picard

2

Capucine Picard

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Karine Chemin

Karine Chemin

3

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Stéphanie Dogniaux

Stéphanie Dogniaux

4

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Claire Hivroz

Claire Hivroz

6

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author name string

Françoise le Deist

Seminars in Immunopathology

5

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language of work or name

English

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publication date

June 2010

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published in

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volume

32

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issue

2

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page(s)

107-16

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cites work

Selective Defect in Antigen-Induced TCR Internalization at the Immune Synapse of CD8 T Cells Bearing the ZAP-70(Y292F) Mutation

1 reference

https://api.crossref.org/works/10.1007%2FS00281-010-0196-X

TCR/CD3 down-modulation and zeta degradation are regulated by ZAP-70.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-010-0196-X

Distinct T cell developmental consequences in humans and mice expressing identical mutations in the DLAARN motif of ZAP-70.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-010-0196-X

Regulation of beta 1 integrin-mediated adhesion by T cell receptor signaling involves ZAP-70 but differs from signaling events that regulate transcriptional activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-010-0196-X

The Th2 lymphoproliferation developing in LatY136F mutant mice triggers polyclonal B cell activation and systemic autoimmunity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-010-0196-X

Control of TCR-mediated activation of beta 1 integrins by the ZAP-70 tyrosine kinase interdomain B region and the linker for activation of T cells adapter protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-010-0196-X

Early phosphorylation kinetics of proteins involved in proximal TCR-mediated signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-010-0196-X

Th2 lymphoproliferative disorder of LatY136F mutant mice unfolds independently of TCR-MHC engagement and is insensitive to the action of Foxp3+ regulatory T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-010-0196-X

Genetic evidence for differential coupling of Syk family kinases to the T-cell receptor: reconstitution studies in a ZAP-70-deficient Jurkat T-cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-010-0196-X

Enhancement of lymphocyte responsiveness by a gain-of-function mutation of ZAP-70.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-010-0196-X

Interdomain B in ZAP-70 regulates but is not required for ZAP-70 signaling function in lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-010-0196-X

Clonotypic Surface Structure on Human T Lymphocytes: Functional and Biochemical Analysis of the Antigen Receptor Complex

21 January 2018

1 reference

12 December 2020

Phosphorylation of Tyr319 in ZAP-70 is required for T-cell antigen receptor-dependent phospholipase C-gamma1 and Ras activation

1 reference

12 December 2020

Retrovirus-mediated transduction of primary ZAP-70-deficient human T cells results in the selective growth advantage of gene-corrected cells: implications for gene therapy

1 reference

12 December 2020

Signal extinction and T cell repolarization in T helper cell-antigen-presenting cell conjugates

1 reference

12 December 2020

Perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase Syk

1 reference

12 December 2020

STIM1 mutation associated with a syndrome of immunodeficiency and autoimmunity

1 reference

12 December 2020

1 reference

12 December 2020

Alternative antigen receptor (TCR) signaling in T cells derived from ZAP-70-deficient patients expressing high levels of Syk

1 reference

12 December 2020

Syk and ZAP-70 mediate recruitment of p56lck/CD4 to the activated T cell receptor/CD3/zeta complex

1 reference

12 December 2020

Relation of gene expression phenotype to immunoglobulin mutation genotype in B cell chronic lymphocytic leukemia

1 reference

12 December 2020

The Cbl phosphotyrosine-binding domain selects a D(N/D)XpY motif and binds to the Tyr292 negative regulatory phosphorylation site of ZAP-70.

1 reference

12 December 2020

Pre-T cell receptor signals are responsible for the down-regulation of Syk protein tyrosine kinase expression

1 reference

12 December 2020

Cbl promotes ubiquitination of the T cell receptor zeta through an adaptor function of Zap-70.

1 reference

12 December 2020

ZAP-70 tyrosine kinase is required for LFA-1-dependent T cell migration

1 reference

12 December 2020

Syk tyrosine kinase required for mouse viability and B-cell development

1 reference

12 December 2020

Specific immunoglobulin E responses in ZAP-70-deficient patients are mediated by Syk-dependent T-cell receptor signalling

1 reference

12 December 2020

Serial triggering of many T-cell receptors by a few peptide-MHC complexes

1 reference

12 December 2020

Temperature-sensitive ZAP70 mutants degrading through a proteasome-independent pathway. Restoration of a kinase domain mutant by Cdc37.

1 reference

12 December 2020

Activating and Inhibitory Mutations in Adjacent Tyrosines in the Kinase Domain of ZAP-70

1 reference

12 December 2020

LAT is required for TCR-mediated activation of PLCgamma1 and the Ras pathway

1 reference

12 December 2020

p56lck interacts via its src homology 2 domain with the ZAP-70 kinase

1 reference

12 December 2020

Regulation of PAK activation and the T cell cytoskeleton by the linker protein SLP-76

1 reference

12 December 2020

Human severe combined immunodeficiency due to a defect in ZAP-70, a T cell tyrosine kinase

1 reference

12 December 2020

T cell development and T cell responses in mice with mutations affecting tyrosines 292 or 315 of the ZAP-70 protein tyrosine kinase

1 reference

12 December 2020

Internalization and intracellular fate of TCR-CD3 complexes

1 reference

12 December 2020

Phenotypic features of selective T cell deficiency characterized by absence of CD8+ T lymphocytes and undetectable mRNA for ZAP-70 kinase

1 reference

12 December 2020

Dynamic recruitment of the adaptor protein LAT: LAT exists in two distinct intracellular pools and controls its own recruitment

1 reference

12 December 2020

Dok-1 and Dok-2 are negative regulators of T cell receptor signaling

1 reference

12 December 2020

Induction of T helper type 2 immunity by a point mutation in the LAT adaptor

1 reference

12 December 2020

Tyrosine 319 in the interdomain B of ZAP-70 is a binding site for the Src homology 2 domain of Lck

1 reference

12 December 2020

Clinical heterogeneity can hamper the diagnosis of patients with ZAP70 deficiency

1 reference

12 December 2020

T cell self-reactivity forms a cytokine milieu for spontaneous development of IL-17+ Th cells that cause autoimmune arthritis.

1 reference

12 December 2020

Differential requirements for ZAP-70 in TCR signaling and T cell development

1 reference

12 December 2020

Essential role for ZAP-70 in both positive and negative selection of thymocytes

1 reference

12 December 2020

T cell activation stimulates the association of enzymatically active tyrosine-phosphorylated ZAP-70 with the Crk adapter proteins

1 reference

12 December 2020

Loss of the LAT adaptor converts antigen-responsive T cells into pathogenic effectors that function independently of the T cell receptor

1 reference

12 December 2020

Function of CD3 epsilon-mediated signals in T cell development

1 reference

12 December 2020

A primary T-cell immunodeficiency associated with defective transmembrane calcium influx

1 reference

12 December 2020

Severe Combined Immunodeficiency with Absence of Peripheral Blood CD8+ T Cells Due to ZAP-70 Deficiency

1 reference

12 December 2020

Altered thymic T-cell selection due to a mutation of the ZAP-70 gene causes autoimmune arthritis in mice

1 reference

12 December 2020

Dynamic molecular interactions linking the T cell antigen receptor to the actin cytoskeleton.

1 reference

12 December 2020

Studies of patients' thymi aid in the discovery and characterization of immunodeficiency in humans

1 reference

12 December 2020

Defective T cell receptor signaling and CD8+ thymic selection in humans lacking zap-70 kinase

1 reference

12 December 2020

Gads/Grb2-mediated association with LAT is critical for the inhibitory function of Gab2 in T cells

1 reference

12 December 2020

Spontaneous development of autoimmune arthritis due to genetic anomaly of T cell signal transduction: Part 1.

1 reference

12 December 2020

Depletion of CD8+ cells in human thymic medulla results in selective immune deficiency

1 reference

12 December 2020

A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function

1 reference

12 December 2020

Internalization and cycling of the T cell antigen receptor. Role of protein kinase C

1 reference

12 December 2020

ZAP-70: a 70 kd protein-tyrosine kinase that associates with the TCR zeta chain

1 reference

12 December 2020

In the immune synapse, ZAP-70 controls T cell polarization and recruitment of signaling proteins but not formation of the synaptic pattern.

1 reference

12 December 2020

A spontaneously arising mutation in the DLAARN motif of murine ZAP-70 abrogates kinase activity and arrests thymocyte development

1 reference

12 December 2020

ZAP-70 deficiency in an autosomal recessive form of severe combined immunodeficiency

1 reference

12 December 2020

Opposing functions of the T cell receptor kinase ZAP-70 in immunity and tolerance differentially titrate in response to nucleotide substitutions.

1 reference

12 December 2020

T cell receptor for antigen induces linker for activation of T cell-dependent activation of a negative signaling complex involving Dok-2, SHIP-1, and Grb-2

1 reference

12 December 2020

ZAP-70 compared with immunoglobulin heavy-chain gene mutation status as a predictor of disease progression in chronic lymphocytic leukemia

1 reference

12 December 2020

Signaling through ZAP-70 is required for CXCL12-mediated T-cell transendothelial migration

1 reference

12 December 2020

ZAP-70 directly enhances IgM signaling in chronic lymphocytic leukemia

1 reference

12 December 2020

Regulation of T cell receptor expression in immature CD4+CD8+ thymocytes by p56lck tyrosine kinase: basis for differential signaling by CD4 and CD8 in immature thymocytes expressing both coreceptor molecules

1 reference

12 December 2020

Structural basis for the inhibition of tyrosine kinase activity of ZAP-70

1 reference

12 December 2020

Activation of ZAP-70 kinase activity by phosphorylation of tyrosine 493 is required for lymphocyte antigen receptor function

1 reference

12 December 2020

ZAP-70 enhances IgM signaling independent of its kinase activity in chronic lymphocytic leukemia

1 reference

12 December 2020

Intramolecular regulatory switch in ZAP-70: analogy with receptor tyrosine kinases.

1 reference

12 December 2020

ZAP-70 expression and prognosis in chronic lymphocytic leukaemia

1 reference

12 December 2020

Herpesvirus saimiri replaces ZAP-70 for CD3- and CD2-mediated T cell activation.

1 reference

12 December 2020

Mutation of the phospholipase C-gamma1-binding site of LAT affects both positive and negative thymocyte selection

1 reference

12 December 2020

On the dynamics of TCR:CD3 complex cell surface expression and downmodulation

1 reference

12 December 2020

Hypomorphic mutation of ZAP70 in human results in a late onset immunodeficiency and no autoimmunity.

1 reference

12 December 2020

Existence of activated and memory CD4+ T cells in peripheral blood and their skin infiltration in CD8 deficiency.

1 reference

12 December 2020

Molecular basis for interaction of the protein tyrosine kinase ZAP-70 with the T-cell receptor

1 reference

12 December 2020

Synovial B cells of rheumatoid arthritis express ZAP-70 which increases the survival and correlates with the inflammatory and autoimmune phenotype.

1 reference

12 December 2020

A role for fungal {beta}-glucans and their receptor Dectin-1 in the induction of autoimmune arthritis in genetically susceptible mice

1 reference

12 December 2020

[Primary immunodeficiency secondary to ZAP-70 deficiency]

1 reference

12 December 2020

Functional analysis of LAT in TCR-mediated signaling pathways using a LAT-deficient Jurkat cell line

1 reference

12 December 2020

A LAT mutation that inhibits T cell development yet induces lymphoproliferation

1 reference

12 December 2020

Tolerance of T-cell clones is associated with membrane antigen changes

1 reference

12 December 2020

Differential requirement of ZAP-70 for CD2-mediated activation pathways of mature human T cells

1 reference

12 December 2020

Unexpected requirement for ZAP-70 in pre-B cell development and allelic exclusion.

1 reference

12 December 2020

Analysis of the interaction of ZAP-70 and syk protein-tyrosine kinases with the T-cell antigen receptor by plasmon resonance

1 reference

12 December 2020

Endocytosis and recycling of the T3-T cell receptor complex. The role of T3 phosphorylation

1 reference

12 December 2020

Mechanism of recruitment of WASP to the immunological synapse and of its activation following TCR ligation

1 reference

12 December 2020

The structure, regulation, and function of ZAP-70.

1 reference

12 December 2020

Tyrosine 319, a newly identified phosphorylation site of ZAP-70, plays a critical role in T cell antigen receptor signaling

1 reference

12 December 2020

Regulation of Zap-70 by Src family tyrosine protein kinases in an antigen-specific T-cell line

1 reference

12 December 2020

Expression of ZAP-70 is associated with increased B-cell receptor signaling in chronic lymphocytic leukemia

1 reference

12 December 2020