Cbl escapes Cdc42-mediated inhibition by downregulation of the adaptor molecule betaPix (Q24300886)

4

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Ivan Đikić

object named as

I Dikic

5

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author name string

M H H Schmidt

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I Szymkiewicz

A novel regulator of p21-activated kinases

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language of work or name

English

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publication date

18 May 2006

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published in

Oncogene

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volume

25

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issue

21

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page(s)

3071-8

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cites work

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Novel regulatory mechanisms for the Dbl family guanine nucleotide exchange factor Cool-2/alpha-Pix

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The Cbl proteins are binding partners for the Cool/Pix family of p21-activated kinase-binding proteins

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Sprouty2 acts at the Cbl/CIN85 interface to inhibit epidermal growth factor receptor downregulation

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Multiple monoubiquitination of RTKs is sufficient for their endocytosis and degradation

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hSpry2 is targeted to the ubiquitin-dependent proteasome pathway by c-Cbl

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Cbl promotes clustering of endocytic adaptor proteins.

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Suppressors of T-cell receptor signaling Sts-1 and Sts-2 bind to Cbl and inhibit endocytosis of receptor tyrosine kinases

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Identification of a novel proline-arginine motif involved in CIN85-dependent clustering of Cbl and down-regulation of epidermal growth factor receptors.

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p85 beta-PIX is required for cell motility through phosphorylations of focal adhesion kinase and p38 MAP kinase

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PAK kinases are directly coupled to the PIX family of nucleotide exchange factors

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Endocytosis of Receptor Tyrosine Kinases Is Driven by Monoubiquitylation, Not Polyubiquitylation

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The endophilin-CIN85-Cbl complex mediates ligand-dependent downregulation of c-Met

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Interaction of alphaPIX (ARHGEF6) with beta-parvin (PARVB) suggests an involvement of alphaPIX in integrin-mediated signaling

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Sprouty fine-tunes EGF signaling through interlinked positive and negative feedback loops

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The Cbl interactome and its functions

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Phosphorylation of p85 beta PIX, a Rac/Cdc42-specific guanine nucleotide exchange factor, via the Ras/ERK/PAK2 pathway is required for basic fibroblast growth factor-induced neurite outgrowth

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Cbl-CIN85-endophilin complex mediates ligand-induced downregulation of EGF receptors

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CIN85 participates in Cbl-b-mediated down-regulation of receptor tyrosine kinases

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Molecular mechanisms underlying endocytosis and sorting of ErbB receptor tyrosine kinases

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Activated Cdc42 Sequesters c-Cbl and Prevents EGF Receptor Degradation

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