MCL-1 is a stress sensor that regulates autophagy in a developmentally regulated manner (Q24313648)

2

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J Nicole Le Grand

3

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Nicole Arbour

4

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Jacqueline L Vanderluit

5

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David S Park

6

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Joseph T Opferman

7

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Ruth S Slack

Antagonism of Beclin 1-dependent autophagy by BCL-2 at the endoplasmic reticulum requires NAF-1

8

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language of work or name

English

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publication date

19 January 2011

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published in

The EMBO Journal

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volume

30

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issue

2

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page(s)

395-407

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cites work

1 reference

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Ambra1 regulates autophagy and development of the nervous system

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Functional and physical interaction between Bcl-X(L) and a BH3-like domain in Beclin-1

19 March 2017

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An internal EELD domain facilitates mitochondrial targeting of Mcl-1 via a Tom70-dependent pathway

19 March 2017

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Glycogen synthase kinase-3 regulates mitochondrial outer membrane permeabilization and apoptosis by destabilization of MCL-1

19 March 2017

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Mule/ARF-BP1, a BH3-only E3 ubiquitin ligase, catalyzes the polyubiquitination of Mcl-1 and regulates apoptosis

19 March 2017

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Endoplasmic reticulum BIK initiates DRP1-regulated remodelling of mitochondrial cristae during apoptosis.

19 March 2017

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Inhibition of macroautophagy triggers apoptosis

19 March 2017

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Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor

19 March 2017

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Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene

19 March 2017

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The autophagy-related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid beta accumulation in mice

19 March 2017

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Differential interactions between Beclin 1 and Bcl-2 family members

19 March 2017

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Loss of autophagy in the central nervous system causes neurodegeneration in mice

19 March 2017

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Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice

19 March 2017

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Regulation of intracellular accumulation of mutant Huntingtin by Beclin 1

19 March 2017

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BH3-ligand regulates access of MCL-1 to its E3 ligase

19 March 2017

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Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy

19 March 2017

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Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease

19 March 2017

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BH-3-only BIK functions at the endoplasmic reticulum to stimulate cytochrome c release from mitochondria

19 March 2017

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Bax-dependent caspase-3 activation is a key determinant in p53-induced apoptosis in neurons

19 March 2017

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Regulation mechanisms and signaling pathways of autophagy

19 March 2017

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Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes

7 April 2017

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The BCL-2 protein family: opposing activities that mediate cell death

7 April 2017

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Mitochondria supply membranes for autophagosome biogenesis during starvation

7 April 2017

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Autophagosome formation from membrane compartments enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum

7 April 2017

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Self-eating and self-killing: crosstalk between autophagy and apoptosis

7 April 2017

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Overview of macroautophagy regulation in mammalian cells

7 April 2017

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Hepatocyte-specific deletion of the antiapoptotic protein myeloid cell leukemia-1 triggers proliferation and hepatocarcinogenesis in mice

27 September 2017

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Beclin 1 gene transfer activates autophagy and ameliorates the neurodegenerative pathology in alpha-synuclein models of Parkinson's and Lewy body diseases

27 September 2017

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Dining in with BCL-2: new guests at the autophagy table.

27 September 2017

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Inhibition of MCL-1 enhances lapatinib toxicity and overcomes lapatinib resistance via BAK-dependent autophagy

27 September 2017

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mTORC1 promotes survival through translational control of Mcl-1.

27 September 2017

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Degradation of Mcl-1 by beta-TrCP mediates glycogen synthase kinase 3-induced tumor suppression and chemosensitization

27 September 2017

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Dissociating the dual roles of apoptosis-inducing factor in maintaining mitochondrial structure and apoptosis

27 September 2017

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p107 regulates neural precursor cells in the mammalian brain

27 September 2017

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Elimination of Mcl-1 is required for the initiation of apoptosis following ultraviolet irradiation

27 September 2017

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A CamKIIalpha iCre BAC allows brain-specific gene inactivation.

27 September 2017

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APAF1 is a key transcriptional target for p53 in the regulation of neuronal cell death.

27 September 2017

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Mouse models of cell death

27 September 2017

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Caspase-mediated cleavage of p130cas in etoposide-induced apoptotic Rat-1 cells

27 September 2017

1 reference

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Apoptosis blocks Beclin 1-dependent autophagosome synthesis: an effect rescued by Bcl-xL.

27 September 2017

1 reference

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Mcl-1 is a key regulator of apoptosis during CNS development and after DNA damage

30 May 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2010.327

The N terminus of the anti-apoptotic BCL-2 homologue MCL-1 regulates its localization and function.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2010.327

Obligate role of anti-apoptotic MCL-1 in the survival of hematopoietic stem cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2010.327

Development and maintenance of B and T lymphocytes requires antiapoptotic MCL-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2010.327

Glycolysis inhibition sensitizes tumor cells to death receptors-induced apoptosis by AMP kinase activation leading to Mcl-1 block in translation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2010.327

Mitochondria are selectively eliminated from eukaryotic cells after blockade of caspases during apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2010.327

21 January 2018

Identifiers

DOI

10.1038/EMBOJ.2010.327

1 reference

1 reference

1 reference

PubMed publication ID

21139567

1 reference