Nicalin and its binding partner Nomo are novel Nodal signaling antagonists (Q24563200)

GOA release 2020-03-11

Nicalin

1 reference

GOA release 2020-03-11

author

Martin Irmler

4

0 references

Laure Bally-Cuif

7

0 references

Christian Haass

8

object named as

Christian Haass

0 references

author name string

Christof Haffner

1

0 references

Mélanie Frauli

2

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Stephanie Topp

3

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Kay Hofmann

5

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Jörg T Regula

Lefty blocks a subset of TGFbeta signals by antagonizing EGF-CFC coreceptors

6

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language of work or name

English

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publication date

4 August 2004

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published in

The EMBO Journal

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volume

23

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issue

15

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page(s)

3041-50

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cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=514924

A high-molecular-weight complex of membrane proteins BAP29/BAP31 is involved in the retention of membrane-bound IgD in the endoplasmic reticulum

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=514924

Dual roles of Cripto as a ligand and coreceptor in the nodal signaling pathway

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=514924

Presenilin and nicastrin regulate each other and determine amyloid beta-peptide production via complex formation

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=514924

Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=514924

TGF-beta signal transduction

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=514924

Mechanisms of TGF-beta signaling from cell membrane to the nucleus

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=514924

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=514924

Stages of embryonic development of the zebrafish

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=514924

Alzheimer's disease: genes, proteins, and therapy

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=514924

Inhibition of excess nodal signaling during mouse gastrulation by the transcriptional corepressor DRAP1

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=514924

Presenilin 1 is required for maturation and cell surface accumulation of nicastrin

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=514924

Axis formation and patterning in zebrafish

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=514924

The transcription factor FoxH1 (FAST) mediates Nodal signaling during anterior-posterior patterning and node formation in the mouse

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=514924

Cloning and characterization of a novel human cDNA that has DNA similarity to the conserved region of the collagenase gene family

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=514924

Two modes by which Lefty proteins inhibit nodal signaling

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=514924

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=514924

Blue native electrophoresis for isolation of membrane protein complexes in enzymatically active form

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=514924

A transcriptional partner for MAD proteins in TGF-beta signalling

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=514924

The Cerberus/Dan-family protein Charon is a negative regulator of Nodal signaling during left-right patterning in zebrafish

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=514924

Take five--BACE and the gamma-secretase quartet conduct Alzheimer's amyloid beta-peptide generation.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=514924

Nodal Signaling in Vertebrate Development

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=514924

Tomoregulin-1 (TMEFF1) inhibits nodal signaling through direct binding to the nodal coreceptor Cripto.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=514924

Notch and Presenilin: regulated intramembrane proteolysis links development and degeneration.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=514924

Vertebrate development: taming the nodal waves

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=514924

Extracellular regulation of BMP signaling in vertebrates: a cocktail of modulators

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=514924

PEN-2 is an integral component of the gamma-secretase complex required for coordinated expression of presenilin and nicastrin

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=514924

Complex N-linked glycosylated nicastrin associates with active gamma-secretase and undergoes tight cellular regulation

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=514924

aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=514924

A gamma-secretase inhibitor blocks Notch signaling in vivo and causes a severe neurogenic phenotype in zebrafish

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=514924

ER transport signals and trafficking of potassium channels and receptors

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=514924

gamma-Secretase, Notch, Abeta and Alzheimer's disease: where do the presenilins fit in?

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=514924

Nodal signaling in early vertebrate embryos: themes and variations

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=514924

Early eye development in vertebrates

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=514924

The role of prechordal mesendoderm in neural patterning

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=514924

The EGF-CFC gene family in vertebrate development.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=514924

Nodal signalling in vertebrate development.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=514924

Head-organizing activities of endodermal tissues in vertebrates

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=514924

Antivin, a novel and divergent member of the TGFbeta superfamily, negatively regulates mesoderm induction.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=514924

Mutation of the beta-amyloid precursor protein in familial Alzheimer's disease increases beta-protein production

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=514924

Single-cell internalization during zebrafish gastrulation.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=514924

A molecular pathway leading to endoderm formation in zebrafish

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=514924

Zebrafish organizer development and germ-layer formation require nodal-related signals

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=514924

Casting an eye over cyclopia

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=514924

Regionalization of the prosencephalic neural plate.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=514924

Cellular expression and proteolytic processing of presenilin proteins is developmentally regulated during neuronal differentiation

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=514924

dino and mercedes, two genes regulating dorsal development in the zebrafish embryo.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=514924

A flexible motif search technique based on generalized profiles.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=514924

Anterior patterning in mouse.

30 May 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.EMBOJ.7600307

Lefty-dependent inhibition of Nodal- and Wnt-responsive organizer gene expression is essential for normal gastrulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.EMBOJ.7600307

Lefty proteins are long-range inhibitors of squint-mediated nodal signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.EMBOJ.7600307

Reconstitution of gamma-secretase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.EMBOJ.7600307

Lefty antagonism of Squint is essential for normal gastrulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.EMBOJ.7600307

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.EMBOJ.7600307

Nicastrin is required for gamma-secretase cleavage of the Drosophila Notch receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.EMBOJ.7600307

Inhibition of Nodal signalling by Lefty mediated through interaction with common receptors and efficient diffusion

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.EMBOJ.7600307

Three structurally and functionally conserved Hlx genes in zebrafish

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.EMBOJ.7600307

Nicastrin, a presenilin-interacting protein, contains an aminopeptidase/transferrin receptor superfamily domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.EMBOJ.7600307

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=514924

Anterior movement of ventral diencephalic precursors separates the primordial eye field in the neural plate and requires cyclops.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=514924

Specification of cell fates at the dorsal margin of the zebrafish gastrula.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=514924

Activin- and Nodal-related factors control antero–posterior patterning of the zebrafish embryo

28 November 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.EMBOJ.7600307

Cell fate specification and competence by Coco, a maternal BMP, TGFbeta and Wnt inhibitor

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/15257293

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Goosecoid expression in neurectoderm and mesendoderm is disrupted in zebrafish cyclops gastrulas

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/15257293