Chromatin regulation and genome maintenance by mammalian SIRT6 (Q24634557)

Trends in Biochemical Sciences

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volume

36

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issue

1

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page(s)

39-46

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cites work

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SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin

7 April 2017

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SIRT6 in DNA repair, metabolism and ageing

7 April 2017

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SIRT1 regulates the histone methyl-transferase SUV39H1 during heterochromatin formation

7 April 2017

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SirT3 is a nuclear NAD+-dependent histone deacetylase that translocates to the mitochondria upon cellular stress

7 April 2017

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SirT2 is a histone deacetylase with preference for histone H4 Lys 16 during mitosis

7 April 2017

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Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins

7 April 2017

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7 April 2017

series ordinal

1

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Sir2 mediates longevity in the fly through a pathway related to calorie restriction

7 April 2017

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Human SirT1 interacts with histone H1 and promotes formation of facultative heterochromatin

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The human Sir2 ortholog, SIRT2, is an NAD+-dependent tubulin deacetylase

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7 April 2017

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Characterization of five human cDNAs with homology to the yeast SIR2 gene: Sir2-like proteins (sirtuins) metabolize NAD and may have protein ADP-ribosyltransferase activity

7 April 2017

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Four genes responsible for a position effect on expression from HML and HMR in Saccharomyces cerevisiae

7 April 2017

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Chromatin modifications and their function

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7 April 2017

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Acetylation of lysine 56 of histone H3 catalyzed by RTT109 and regulated by ASF1 is required for replisome integrity

7 April 2017

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Rtt109 acetylates histone H3 lysine 56 and functions in DNA replication

7 April 2017

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The sirtuins hst3 and Hst4p preserve genome integrity by controlling histone h3 lysine 56 deacetylation.

7 April 2017

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Sir2 blocks extreme life-span extension.

7 April 2017

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Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae

7 April 2017

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7 April 2017

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The silencing protein SIR2 and its homologs are NAD-dependent protein deacetylases

7 April 2017

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7 April 2017

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7 April 2017

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7 April 2017

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7 April 2017

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7 April 2017

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7 April 2017

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7 April 2017

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Mouse Sir2 homolog SIRT6 is a nuclear ADP-ribosyltransferase

7 April 2017

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Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins

7 April 2017

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The histone deacetylase Sirt6 regulates glucose homeostasis via Hif1alpha

7 April 2017

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Essential role of limiting telomeres in the pathogenesis of Werner syndrome

7 April 2017

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Modifiers of position effect are shared between telomeric and silent mating-type loci in S. cerevisiae.

7 April 2017

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Telomeres shorten during ageing of human fibroblasts

7 April 2017

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7 April 2017

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Mammalian sirtuins--emerging roles in physiology, aging, and calorie restriction

7 April 2017

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An enzymatic activity in the yeast Sir2 protein that is essential for gene silencing

7 April 2017

1 reference

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Transcriptional silencing of Ty1 elements in the RDN1 locus of yeast

7 April 2017

1 reference

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An unusual form of transcriptional silencing in yeast ribosomal DNA

7 April 2017

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Histone H3 and H4 N-termini interact with SIR3 and SIR4 proteins: a molecular model for the formation of heterochromatin in yeast

7 April 2017

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SIRT6 stabilizes DNA-dependent protein kinase at chromatin for DNA double-strand break repair

7 April 2017

1 reference

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Functional dissection of SIRT6: identification of domains that regulate histone deacetylase activity and chromatin localization

27 September 2017

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Cell cycle-dependent deacetylation of telomeric histone H3 lysine K56 by human SIRT6.

27 September 2017

1 reference

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Histone H3-K56 acetylation is important for genomic stability in mammals

27 September 2017

1 reference

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Crosstalk among Histone Modifications

27 September 2017

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27 September 2017

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An elaborate pathway required for Ras-mediated epigenetic silencing

27 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2991557

Sir2 deacetylates histone H3 lysine 56 to regulate telomeric heterochromatin structure in yeast.

27 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2991557

Replication and protection of telomeres

27 September 2017

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Sir2 and calorie restriction in yeast: a skeptical perspective.

27 September 2017

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From broken to old: DNA damage, IGF1 endocrine suppression and aging

27 September 2017

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The epigenetic regulation of mammalian telomeres

27 September 2017

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Inflammation-associated cancer: NF-kappaB is the lynchpin

27 September 2017

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Mechanism and regulation of human non-homologous DNA end-joining

27 September 2017

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27 September 2017

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27 September 2017

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Steps in assembly of silent chromatin in yeast: Sir3-independent binding of a Sir2/Sir4 complex to silencers and role for Sir2-dependent deacetylation

27 September 2017

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The mechanism and regulation of chromosomal V(D)J recombination

27 September 2017

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Coupling of histone deacetylation to NAD breakdown by the yeast silencing protein Sir2: Evidence for acetyl transfer from substrate to an NAD breakdown product

27 September 2017

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SIRT6 protects against pathological damage caused by diet-induced obesity

27 September 2017

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30 May 2018

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The sirtuin SIRT6 deacetylates H3 K56Ac in vivo to promote genomic stability

30 May 2018

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Hypoxia, HIF1 and glucose metabolism in the solid tumour

28 November 2018

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28 November 2018

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PubMed

https://pubmed.ncbi.nlm.nih.gov/20729089

12 December 2020

inferred from PubMed ID database lookup

The hypoxic response and aging

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https://pubmed.ncbi.nlm.nih.gov/20729089

12 December 2020

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Telomere dysfunction and Atm deficiency compromises organ homeostasis and accelerates ageing

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PubMed

https://pubmed.ncbi.nlm.nih.gov/20729089

12 December 2020

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Identifiers

DOI

10.1016/J.TIBS.2010.07.009

1 reference

1 reference

1 reference

PubMed publication ID

20729089

1 reference