PU.1 downregulation in murine radiation-induced acute myeloid leukaemia (AML): from molecular mechanism to human AML (Q26863329)

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2 March 2020

review article

3 references

11 July 2020

17 July 2021

PU.1 downregulation in murine radiation-induced acute myeloid leukaemia (AML): from molecular mechanism to human AML (English)

2 references

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radiation-induced leukemia

2 March 2020

main subject

acute myeloid leukemia

7 references

3 April 2019

2 August 2019

11 December 2019

18 December 2019

22 December 2019

23 December 2019

11 July 2020

proto-oncogene protein

1 reference

2 August 2019

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11 December 2019

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18 December 2019

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22 December 2019

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23 December 2019

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radiation-induced neoplasms

11 July 2020

1 reference

11 July 2020

1 reference

1 reference

17 July 2021

3

1 reference

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2 March 2020

Christophe Badie

series ordinal

4

1 reference

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2 March 2020

author name string

Tom Verbiest

series ordinal

1

1 reference

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2 March 2020

Simon Bouffler

series ordinal

2

1 reference

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2 March 2020

language of work or name

1 reference

6 March 2015

1 reference

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2 March 2020

1 April 2015

2 references

11 July 2020

17 July 2021

10 references

3 April 2019

2 August 2019

11 December 2019

18 December 2019

22 December 2019

23 December 2019

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2 March 2020

11 July 2020

17 July 2021

36

2 references

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2 March 2020

issue

4

2 references

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2 March 2020

page(s)

413-419

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Creative Commons Attribution-NonCommercial 4.0 International

2 March 2020

copyright license

8 references

3 April 2019

2 August 2019

11 December 2019

18 December 2019

22 December 2019

23 December 2019

11 July 2020

on focus list of Wikimedia project

17 July 2021

ScienceSource

0 references

cites work

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The transcription factor PU.1 is a critical regulator of cellular communication in the immune system

28 September 2017

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A two-mutation model of radiation-induced acute myeloid leukemia using historical mouse data

28 September 2017

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Sfpi1/PU.1 mutations in mouse radiation-induced acute myeloid leukaemias affect mRNA and protein abundance and associate with disrupted transcription

28 September 2017

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Hematopoietic stem cell quiescence promotes error-prone DNA repair and mutagenesis

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PU.1 is regulated by NF-kappaB through a novel binding site in a 17 kb upstream enhancer element.

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Dose-dependent repression of T-cell and natural killer cell genes by PU.1 enforces myeloid and B-cell identity.

28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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31 May 2018

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31 May 2018

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Evidence for complex multigenic inheritance of radiation AML susceptibility in mice revealed using a surrogate phenotypic assay.

31 May 2018

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21 January 2018

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21 January 2018

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Allelic loss on chromosome 4 (Lyr2/TLSR5) is associated with myeloid, B-lympho-myeloid, and lymphoid (B and T) mouse radiation-induced leukemias.

21 January 2018

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Flt3-ITD mutations in a mouse model of radiation-induced acute myeloid leukaemia

21 January 2018

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PU.1 is a suppressor of myeloid leukemia, inactivated in mice by gene deletion and mutation of its DNA binding domain.

21 January 2018

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Leukemogenesis in heterozygous PU.1 knockout mice.

21 January 2018

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Cell surface marker phenotypes and gene expression profiles of murine radiation-induced acute myeloid leukemia stem cells are similar to those of common myeloid progenitors.

21 January 2018

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Acute myeloid leukemia induced by graded reduction of a lineage-specific transcription factor, PU.1.

21 January 2018

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Requirement of transcription factor PU.1 in the development of multiple hematopoietic lineages.

21 January 2018

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Identification and characterization of enhancers controlling the inflammatory gene expression program in macrophages.

21 January 2018

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Aggressive acute myeloid leukemia in PU.1/p53 double-mutant mice

21 January 2018

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The impact of therapy-related acute myeloid leukemia (AML) on outcome in 2853 adult patients with newly diagnosed AML.

21 January 2018

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Heterozygous PU.1 mutations are associated with acute myeloid leukemia.

21 January 2018

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Heterozygous deletion of the PU.1 locus in human AML.

21 January 2018

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Essential role of Jun family transcription factors in PU.1 knockdown-induced leukemic stem cells.

21 January 2018

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The myeloid master regulator transcription factor PU.1 is inactivated by AML1-ETO in t(8;21) myeloid leukemia

21 January 2018

1 reference

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Chromosomal instability in acute myelocytic leukemia and myelodysplastic syndrome patients among atomic bomb survivors

21 January 2018

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12 December 2020

A specific chromosomal deletion in murine leukemic cells induced by radiation with different qualities

1 reference

12 December 2020

Chromosomal abnormalities in neutron-induced acute myeloid leukemias in CBA/H mice

1 reference

12 December 2020

Evidence for clustered tumour suppressor gene loci on mouse chromosomes 2 and 4 in radiation-induced acute myeloid leukaemia

1 reference

12 December 2020

Lentiviral PU.1 overexpression restores differentiation in myeloid leukemic blasts

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12 December 2020

The Transcription Factor PU.1 Controls Dendritic Cell Development and Flt3 Cytokine Receptor Expression in a Dose-Dependent Manner

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12 December 2020

Identifiers

DOI

10.1093/CARCIN/BGV016

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25750172%20AND%20SRC:MED&resulttype=core&format=json

release_bmw7w4h63bhbxftcxgpouw7xce

2 March 2020

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/bmw7w4h63bhbxftcxgpouw7xce

24 November 2022

mapped directly with Wikidata item

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25750172%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

PubMed publication ID

25750172

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25750172%20AND%20SRC:MED&resulttype=core&format=json