Role of genetics in the diagnosis and prognosis of Crohn's disease (Q27003222)

Crossref

language of work or name

1 reference

14 January 2012

1 reference

World Journal of Gastroenterology

published in

1 reference

volume

18

1 reference

issue

2

1 reference

page(s)

105-18

1 reference

Specific association of a CLEC16A/KIAA0350 polymorphism with NOD2/CARD15(-) Crohn's disease patients

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Diverse genome-wide association studies associate the IL12/IL23 pathway with Crohn Disease

21 March 2017

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Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease

21 March 2017

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Genome-wide association study for Crohn's disease in the Quebec Founder Population identifies multiple validated disease loci

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A Nonsynonymous SNP in ATG16L1 Predisposes to Ileal Crohn’s Disease and Is Independent of CARD15 and IBD5

21 March 2017

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Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis

21 March 2017

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IL-23 receptor (IL-23R) gene protects against pediatric Crohn's disease

21 March 2017

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Fhit, a putative tumor suppressor in humans, is a dinucleoside 5',5"'-P1,P3-triphosphate hydrolase

21 March 2017

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The FHIT gene, spanning the chromosome 3p14.2 fragile site and renal carcinoma-associated t(3;8) breakpoint, is abnormal in digestive tract cancers

21 March 2017

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Subversion of innate immune signaling through molecular mimicry

21 March 2017

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Association of variants of the interleukin-23 receptor gene with susceptibility to pediatric Crohn's disease

21 March 2017

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Contribution of the novel inflammatory bowel disease gene IL23R to disease susceptibility and phenotype

21 March 2017

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Novel Crohn disease locus identified by genome-wide association maps to a gene desert on 5p13.1 and modulates expression of PTGER4

21 March 2017

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How NOD2 mutations predispose to Crohn's disease?

21 March 2017

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Associations between NOD2/CARD15 genotype and phenotype in Crohn's disease--Are we there yet?

21 March 2017

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A genome-wide association study identifies IL23R as an inflammatory bowel disease gene

21 March 2017

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A risk haplotype in the Solute Carrier Family 22A4/22A5 gene cluster influences phenotypic expression of Crohn's disease

21 March 2017

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Mapping of a susceptibility locus for Crohn's disease on chromosome 16

21 March 2017

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A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1

21 March 2017

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Negative regulation of toll-like receptor-mediated immune responses

7 April 2017

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Autophagy: definition, molecular machinery, and potential role in myocardial ischemia-reperfusion injury

7 April 2017

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NOD2/CARD15, ATG16L1 and IL23R gene polymorphisms and childhood-onset of Crohn's disease

28 September 2017

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The cannabinoid 1 receptor (CNR1) 1359 G/A polymorphism modulates susceptibility to ulcerative colitis and the phenotype in Crohn's disease

28 September 2017

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Genome-wide association study in a high-risk isolate for multiple sclerosis reveals associated variants in STAT3 gene

28 September 2017

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Genetics of inflammatory bowel disease: implications for disease pathogenesis and natural history.

28 September 2017

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IL-10 and TNF-alpha promoter haplotypes are associated with childhood Crohn's disease location

28 September 2017

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Strong evidence of a combination polymorphism of the tyrosine kinase 2 gene and the signal transducer and activator of transcription 3 gene as a DNA-based biomarker for susceptibility to Crohn's disease in the Japanese population

28 September 2017

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Crohn's disease: Th1, Th17 or both? The change of a paradigm: new immunological and genetic insights implicate Th17 cells in the pathogenesis of Crohn's disease

28 September 2017

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Role of Nod2 in the development of Crohn's disease

28 September 2017

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The genetics of Crohn's disease

28 September 2017

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Genetic risk profiling and prediction of disease course in Crohn's disease patients

28 September 2017

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Established genetic risk factors do not distinguish early and later onset Crohn's disease

28 September 2017

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Genetic variants of Wnt transcription factor TCF-4 (TCF7L2) putative promoter region are associated with small intestinal Crohn's disease

28 September 2017

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Deletion polymorphism upstream of IRGM associated with altered IRGM expression and Crohn's disease

28 September 2017

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Common variants in the NLRP3 region contribute to Crohn's disease susceptibility

28 September 2017

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Autoimmune diseases: insights from genome-wide association studies

28 September 2017

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Role of STAT3 in inflammatory bowel disease

28 September 2017

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Genome-wide association analysis in sarcoidosis and Crohn's disease unravels a common susceptibility locus on 10p12.2.

28 September 2017

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Adaptive immunity in inflammatory bowel disease: state of the art.

28 September 2017

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The expanding universe of inflammatory bowel disease genetics

28 September 2017

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Power of genetic association studies in the presence of linkage disequilibrium and allelic heterogeneity.

28 September 2017

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Contributions of IBD5, IL23R, ATG16L1, and NOD2 to Crohn's disease risk in a population-based case-control study: evidence of gene-gene interactions

28 September 2017

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An SNP linkage scan identifies significant Crohn's disease loci on chromosomes 13q13.3 and, in Jewish families, on 1p35.2 and 3q29.

28 September 2017

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Analysis of Crohn's disease-related CARD15 polymorphisms in Spanish patients with idiopathic uveitis.

28 September 2017

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Two-stage candidate gene study of chromosome 3p demonstrates an association between nonsynonymous variants in the MST1R gene and Crohn's disease.

28 September 2017

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New links to the pathogenesis of Crohn disease provided by genome-wide association scans

28 September 2017

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rs1004819 is the main disease-associated IL23R variant in German Crohn's disease patients: combined analysis of IL23R, CARD15, and OCTN1/2 variants

28 September 2017

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Genome-wide association scans identify multiple confirmed susceptibility loci for Crohn's disease: lessons for study design

28 September 2017

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Clinical applications of NOD2/CARD15 mutations in Crohn's disease.

28 September 2017

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Role of CARD15, DLG5 and OCTN genes polymorphisms in children with inflammatory bowel diseases

28 September 2017

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Review article: genetic susceptibility and application of genetic testing in clinical management of inflammatory bowel disease.

28 September 2017

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NOD2 regulation of Toll-like receptor responses and the pathogenesis of Crohn's disease

28 September 2017

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Crohn's disease in Japanese is associated with a SNP-haplotype of N-acetyltransferase 2 gene

28 September 2017

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Influence of IL-6, COL1A1, and VDR gene polymorphisms on bone mineral density in Crohn's disease

28 September 2017

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Polymorphisms in the DLG5 and OCTN cation transporter genes in Crohn's disease.

28 September 2017

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Regulation of innate immunity by Rho GTPases

28 September 2017

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Epithelioid granulomas, pattern recognition receptors, and phenotypes of Crohn's disease

28 September 2017

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CARD15 gene polymorphisms in patients with spondyloarthropathies identify a specific phenotype previously related to Crohn's disease

28 September 2017

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Inflammatory bowel disease gene hunting by linkage analysis: rationale, methodology, and present status of the field

28 September 2017

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Thiopurine S-methyltransferase genetic polymorphism in the Thai population

28 September 2017

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Genome wide scan in a Flemish inflammatory bowel disease population: support for the IBD4 locus, population heterogeneity, and epistasis

28 September 2017

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Molecular genetics of Crohn's disease

28 September 2017

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The CARD15 (also known as NOD2) gene in Crohn's disease: are there implications for current clinical practice?

28 September 2017

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Polymorphisms in human MDR1 (P-glycoprotein): recent advances and clinical relevance

28 September 2017

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CARD15/NOD2 gene variants are associated with familially occurring and complicated forms of Crohn's disease.

28 September 2017

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Lack of common NOD2 variants in Japanese patients with Crohn's disease

28 September 2017

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Familial and sporadic inflammatory bowel disease: different entities?

28 September 2017

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Vitamin D receptor gene polymorphism: association with Crohn's disease susceptibility.

28 September 2017

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Genetics of inflammatory bowel disease. A personal view on progress and prospects

28 September 2017

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From inflammation to lesion

28 September 2017

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Using biological networks to search for interacting loci in genome-wide association studies

28 September 2017

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FcRL3 gene promoter variant is associated with peripheral arthritis in Crohn's disease.

31 May 2018

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Chemokines in inflammatory bowel disease

31 May 2018

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TPMT in the treatment of Crohn's disease with azathioprine

31 May 2018

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Differences in risk of Crohn's disease in offspring of mothers and fathers with inflammatory bowel disease.

31 May 2018

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Pathogenesis and immune mechanisms of chronic inflammatory bowel diseases

31 May 2018

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Response to medical treatment in patients with Crohn's disease: the role of NOD2/CRAD15, disease phenotype, and age of diagnosis

31 May 2018

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Autophagy 16-like 1 rs2241880 G allele is associated with Crohn's disease in German children.

28 November 2018

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Interleukin 10 (IL-10) gene variants and susceptibility for paediatric onset Crohn's disease.

28 November 2018

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Confirmation of multiple Crohn's disease susceptibility loci in a large Dutch-Belgian cohort

28 November 2018

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Common NOD2 mutations are absent in patients with Crohn's disease in India.

28 November 2018

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Polymorphism of the IRGM Gene Might Predispose to Fistulizing Behavior in Crohn's Disease

28 November 2018

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The V249I polymorphism of the CX3CR1 gene is associated with fibrostenotic disease behavior in patients with Crohn's disease

28 November 2018

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Genetic determinants of methotrexate toxicity in rheumatoid arthritis patients: a study of polymorphisms affecting methotrexate transport and folate metabolism

28 November 2018

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ATG16L1 and IL23 receptor (IL23R) genes are associated with disease susceptibility in Hungarian CD patients

28 November 2018

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The role of genetics in inflammatory bowel disease

28 November 2018

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NOD2/CARD15 gene variants are linked to failure of antibiotic treatment in perianal fistulating Crohn's disease

28 November 2018

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The Crohn's disease susceptibility gene DLG5 as a member of the CARD interaction network

28 November 2018

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NOD1 gene E266K polymorphism is associated with disease susceptibility but not with disease phenotype or NOD2/CARD15 in Hungarian patients with Crohn's disease.

28 November 2018

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Clinical and genetic factors associated with sacroiliitis in Crohn's disease

28 November 2018

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Gender-stratified analysis of DLG5 R30Q in 4707 patients with Crohn disease and 4973 controls from 12 Caucasian cohorts.

28 November 2018

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The role of the Toll receptor pathway in susceptibility to inflammatory bowel diseases

28 November 2018

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Role of ASCA and the NOD2/CARD15 mutation Gly908Arg in predicting increased surgical costs in Crohnʼs disease patients: A project of the European Collaborative Study Group on Inflammatory Bowel Disease

28 November 2018

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Macrophage migration inhibitory factor (MIF) -173G/C promoter polymorphism influences upper gastrointestinal tract involvement and disease activity in patients with Crohn's disease.

28 November 2018

1 reference

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DLG5 R30Q variant is a female-specific protective factor in pediatric onset Crohn's disease.

28 November 2018

1 reference

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MDR1 gene: susceptibility in Spanish Crohn's disease and ulcerative colitis patients.

28 November 2018

1 reference

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Toll-like receptor-1, -2, and -6 polymorphisms influence disease extension in inflammatory bowel diseases.

28 November 2018

1 reference

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Association of Organic Cation Transporter Risk Haplotype With Perianal Penetrating Crohn’s Disease but Not With Susceptibility to IBD

28 November 2018

1 reference

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Muramyl dipeptide and toll-like receptor sensitivity in NOD2-associated Crohn's disease

28 November 2018

1 reference

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Tumor necrosis factor receptor gene polymorphisms in Crohn's disease: association with clinical phenotypes

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3257437

The toll-like receptor 4 (TLR4) Asp299Gly polymorphism is associated with colonic localisation of Crohn's disease without a major role for the Saccharomyces cerevisiae mannan-LBP-CD14-TLR4 pathway.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3257437

Acute intestinal obstruction and NOD2/CARD15 mutations among Italian Crohn's disease patients.

28 November 2018

1 reference

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Differential effects of NOD2 variants on Crohn's disease risk and phenotype in diverse populations: a metaanalysis.

28 November 2018

1 reference

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Tumour necrosis factor-alpha receptor 1 and 2 polymorphisms in inflammatory bowel disease and their association with response to infliximab

28 November 2018

1 reference

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Transmission of CARD15 (NOD2) variants within families of patients with inflammatory bowel disease

28 November 2018

1 reference

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Association between polymorphism in IgG Fc receptor IIIa coding gene and biological response to infliximab in Crohn's disease.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3257437

NOD2/CARD15 variants are associated with lower weight at diagnosis in children with Crohn's disease

28 November 2018

1 reference

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A polymorphism of the NFKBIA gene is associated with Crohn's disease patients lacking a predisposing allele of the CARD15 gene.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3257437

NOD2/CARD15 gene polymorphisms and Crohn's disease in the Chinese population.

28 November 2018

1 reference

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Azathioprine therapy and adverse drug reactions in patients with inflammatory bowel disease: impact of thiopurine S-methyltransferase polymorphism

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3257437

Association of HLA-DR genotypes and IL-1ra gene polymorphism with treatment failure of budesonide and disease patterns in Crohn's disease

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3257437

Ethnic differences in thiopurine methyltransferase pharmacogenetics: evidence for allele specificity in Caucasian and Kenyan individuals.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3257437

Gastroduodenal Crohn's disease is associated with NOD2/CARD15 gene polymorphisms, particularly L1007P homozygosity

28 November 2018

1 reference

12 December 2020

IL-22 is increased in active Crohn's disease and promotes proinflammatory gene expression and intestinal epithelial cell migration

1 reference

12 December 2020

The +1059G/C polymorphism in the C-reactive protein (CRP) gene is associated with involvement of the terminal ileum and decreased serum CRP levels in patients with Crohn's disease

1 reference

12 December 2020

Gut microbes, the innate immune system and inflammatory bowel disease: location, location, location

1 reference

12 December 2020

Combined type-1 plasminogen activator inhibitor and NOD2/CARD15 genotyping predicts complicated Crohn's disease behaviour

1 reference

12 December 2020

HLA-DRB1*03, but not the TNFA -308 promoter gene polymorphism, confers protection against fistulising Crohn's disease

1 reference

12 December 2020

CARD15 gene mutations and risk for early surgery in pediatric-onset Crohn's disease

1 reference

12 December 2020

1 reference

12 December 2020

A polymorphism in the macrophage migration inhibitory factor gene is involved in the genetic predisposition of Crohn's disease and associated with cumulative steroid doses

1 reference

12 December 2020

CARD15 Status and Familial Predisposition for Crohn's Disease and Colonic Gene Expression

1 reference

12 December 2020

Heat shock protein gene 70-2 polymorphism is differentially associated with the clinical phenotypes of ulcerative colitis and Crohn's disease

1 reference

12 December 2020

Should family members of IBD patients be screened for CARD15/NOD2 mutations?

1 reference

12 December 2020

Evidence for inflammatory bowel disease of a susceptibility locus on the X chromosome

1 reference

12 December 2020

Association of single nucleotide polymorphisms in the interleukin-4 gene and interleukin-4 receptor gene with Crohn's disease in a British population

1 reference

12 December 2020

A positive response to infliximab in Crohn disease: association with a higher systemic inflammation before treatment but not with -308 TNF gene polymorphism

1 reference

12 December 2020

Positive association of genetic variants in the upstream region of NKX2-3 with Crohn's disease in Japanese patients

1 reference

12 December 2020

Gene expression profiles of mucosal fibroblasts from strictured and nonstrictured areas of patients with Crohn's disease

1 reference

12 December 2020

Autophagy gene ATG16L1 but not IRGM is associated with Crohn's disease in Canadian children

1 reference

12 December 2020

Associations between ABCB1/MDR1 gene polymorphisms and Crohn's disease: a gene-wide study in a pediatric population

1 reference

12 December 2020

Gene-gene interactions in inflammatory bowel disease: biological and clinical implications

1 reference

12 December 2020

CARD15 Gene Variants and Risk of Reoperation in Crohn's Disease Patients

1 reference

12 December 2020

Role of the novel Th17 cytokine IL-17F in inflammatory bowel disease (IBD): upregulated colonic IL-17F expression in active Crohn's disease and analysis of the IL17F p.His161Arg polymorphism in IBD

1 reference

12 December 2020

Investigation of reported associations between the 20q13 and 21q22 loci and pediatric-onset Crohn's disease in Canadian children

1 reference

12 December 2020

A common genetic fingerprint in leprosy and Crohn's disease?

1 reference

12 December 2020

Susceptibility loci reported in genome-wide association studies are associated with Crohn's disease in Canadian children

1 reference

12 December 2020

The −A2518G Polymorphism of Monocyte Chemoattractant Protein-1 Is Associated With Crohn's Disease

1 reference

12 December 2020

The role of Toll-like receptor 4 Asp299Gly and Thr399Ile polymorphisms and CARD15/NOD2 mutations in the susceptibility and phenotype of Crohn's disease

1 reference

12 December 2020

Polymorphism of the heat-shock protein gene Hsp70-2, but not polymorphisms of the IL-10 and CD14 genes, is associated with the outcome of Crohn's disease

1 reference

12 December 2020

Association of NOD2/CARD15 mutations with previous surgical procedures in Crohn's disease

1 reference

12 December 2020

No association between C-reactive protein gene polymorphisms and decrease of C-reactive protein serum concentration after infliximab treatment in Crohn's disease

1 reference

12 December 2020

The 4G/4G genotype of the 4G/5G polymorphism of the type-1 plasminogen activator inhibitor (PAI-1) gene is a determinant of penetrating behaviour in patients with Crohn's disease

1 reference

12 December 2020

TNF-alpha -308A promoter polymorphism is associated with enhanced TNF-alpha production and inflammatory activity in Crohn's patients with fistulizing disease

1 reference

12 December 2020

Precise localization of aphidicolin-induced breakpoints on the short arm of human chromosome 3

1 reference

12 December 2020

Identifiers

DOI

10.3748/WJG.V18.I2.105

0 references

1 reference

PubMed publication ID

22253516

1 reference