Structure-based design of an osteoclast-selective, nonpeptide src homology 2 inhibitor with in vivo antiresorptive activity (Q27626519)

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M Yang

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R Bohacek

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F Cerasoli

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K Stebbins

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R Sundaramoorthi

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M Azimioara

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C Vu

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S Pradeepan

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C Metcalf

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C Haraldson

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T Merry

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D Dalgarno

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S Narula

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M Hatada

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X Lu

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M R van Schravendijk

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S Adams

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S Violette

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J Smith

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W Guan

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C Bartlett

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J Herson

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J Iuliucci

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M Weigele

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T Sawyer

Proceedings of the National Academy of Sciences of the United States of America

26

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language of work or name

English

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publication date

15 August 2000

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published in

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volume

97

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issue

17

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page(s)

9373-8

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cites work

Peptide ligands of pp60(c-src) SH2 domains: a thermodynamic and structural study

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Fibronectin-stimulated signaling from a focal adhesion kinase-c-Src complex: involvement of the Grb2, p130cas, and Nck adaptor proteins

20 March 2017

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Crystal structures of the human p56lck SH2 domain in complex with two short phosphotyrosyl peptides at 1.0 A and 1.8 A resolution

20 March 2017

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Binding of a high affinity phosphotyrosyl peptide to the Src SH2 domain: crystal structures of the complexed and peptide-free forms

20 March 2017

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Recognition of a high-affinity phosphotyrosyl peptide by the Src homology-2 domain of p56lck

20 March 2017

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Autophosphorylation of the focal adhesion kinase, pp125FAK, directs SH2-dependent binding of pp60src

20 March 2017

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Crystal structure of the phosphotyrosine recognition domain SH2 of v-src complexed with tyrosine-phosphorylated peptides

20 March 2017

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Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice

20 March 2017

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Cellular functions regulated by Src family kinases

7 April 2017

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Modular binding domains in signal transduction proteins

7 April 2017

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Src family kinases are required for integrin but not PDGFR signal transduction.

7 April 2017

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Protein tyrosine kinase inhibitors as novel therapeutic agents

22 April 2017

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Rescue of osteoclast function by transgenic expression of kinase-deficient Src in src-/- mutant mice

29 September 2017

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A fluorescence polarization based Src-SH2 binding assay

29 September 2017

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Structure-function relationships in Src family and related protein tyrosine kinases

29 September 2017

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An RNA-binding protein associated with Src through its SH2 and SH3 domains in mitosis

29 September 2017

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On the rat model of human osteopenias and osteoporoses

29 September 2017

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Requirement of pp60c-src expression for osteoclasts to form ruffled borders and resorb bone in mice

29 September 2017

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QXP: powerful, rapid computer algorithms for structure-based drug design.

29 September 2017

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Preclinical pharmacology of CGP 42'446, a new, potent, heterocyclic bisphosphonate compound

2 June 2018

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Adhesion-induced tyrosine phosphorylation of the p130 src substrate

2 June 2018

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A Src SH2 selective binding compound inhibits osteoclast-mediated resorption.

2 June 2018

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An efficient synthesis of a 4'-phosphonodifluoromethyl-3'-formyl-phenylalanine containing SRC SH2 ligand.

21 January 2018

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Src homology-2 domains: structure, mechanisms, and drug discovery

21 January 2018

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New N alpha-guanidinobenzoyl derivatives of hirudin-54-65 containing stabilized carboxyl or phosphoryl groups on the side chain of phenylalanine-63

21 January 2018

1 reference

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The many faces of Src: multiple functions of a prototypical tyrosine kinase

21 January 2018

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Protein tyrosine phosphatases and the control of cellular signaling responses

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/10944210

12 December 2020

inferred from PubMed ID database lookup

The formation of a covalent complex between a dipeptide ligand and the src SH2 domain

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/10944210

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1073/PNAS.97.17.9373

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/v3hb4jf2kfftdgtge2unicsjwu

30 July 2022

release_v3hb4jf2kfftdgtge2unicsjwu

ADS bibcode

2000PNAS...97.9373S

0 references

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/v3hb4jf2kfftdgtge2unicsjwu

30 July 2022

https://api.fatcat.wiki/v0/release/v3hb4jf2kfftdgtge2unicsjwu

1 reference

30 July 2022

https://api.fatcat.wiki/v0/release/v3hb4jf2kfftdgtge2unicsjwu

PubMed publication ID

1 reference

30 July 2022