Crystal structure and kinetic mechanism of aminoglycoside phosphotransferase-2″-IVa (Q27662400)

2

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Nuno Tiago Antunes

3

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Clyde A Smith

4

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Sergei B Vakulenko

Structure of the Antibiotic Resistance Factor Spectinomycin Phosphotransferase from Legionella pneumophila

5

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publication date

August 2010

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published in

Protein Science

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volume

19

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issue

8

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page(s)

1565-76

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cites work

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The Crystal Structures of Substrate and Nucleotide Complexes of Enterococcus faecium Aminoglycoside-2''-Phosphotransferase-IIa [APH(2'')-IIa] Provide Insights into Substrate Selectivity in the APH(2'') Subfamily

20 March 2017

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The crystal structure of aminoglycoside-3'-phosphotransferase-IIa, an enzyme responsible for antibiotic resistance

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Substrate promiscuity of an aminoglycoside antibiotic resistance enzyme via target mimicry

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GTP plus water mimic ATP in the active site of protein kinase CK2

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PHENIX: building new software for automated crystallographic structure determination

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Structure of an enzyme required for aminoglycoside antibiotic resistance reveals homology to eukaryotic protein kinases

20 March 2017

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Catalytic mechanism of enterococcal kanamycin kinase (APH(3')-IIIa): viscosity, thio, and solvent isotope effects support a Theorell-Chance mechanism

20 March 2017

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Kinetic mechanism of aminoglycoside phosphotransferase type IIIa. Evidence for a Theorell-Chance mechanism

20 March 2017

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Absolute metabolite concentrations and implied enzyme active site occupancy in Escherichia coli

20 March 2017

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Interaction of antibiotics with functional sites in 16S ribosomal RNA

7 April 2017

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Purification, crystallization and preliminary X-ray analysis of Enterococcus casseliflavus aminoglycoside-2''-phosphotransferase-IVa

7 April 2017

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Do we still need the aminoglycosides?

29 September 2017

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Characterization of nucleotide pools as a function of physiological state in Escherichia coli

29 September 2017

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Versatility of aminoglycosides and prospects for their future

29 September 2017

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Aminoglycoside antibiotic resistance by enzymatic deactivation

29 September 2017

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Detection of the high-level aminoglycoside resistance gene aph(2")-Ib in Enterococcus faecium

29 September 2017

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Aminoglycoside resistance in enterococci

29 September 2017

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Aminoglycoside-modifying enzymes

29 September 2017

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Prodigious substrate specificity of AAC(6')-APH(2"), an aminoglycoside antibiotic resistance determinant in enterococci and staphylococci

29 September 2017

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A new high-level gentamicin resistance gene, aph(2'')-Id, in Enterococcus spp.

29 September 2017

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A novel gentamicin resistance gene in Enterococcus

29 September 2017

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Molecular genetics of aminoglycoside resistance genes and familial relationships of the aminoglycoside-modifying enzymes.

29 September 2017

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Purification and characterization of aminoglycoside 3'-phosphotransferase type IIa and kinetic comparison with a new mutant enzyme

29 September 2017

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Nucleotide sequence analysis of the gene specifying the bifunctional 6'-aminoglycoside acetyltransferase 2"-aminoglycoside phosphotransferase enzyme in Streptococcus faecalis and identification and cloning of gene regions specifying the two activiti

29 September 2017

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29 September 2017

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New plasmid-mediated nucleotidylation of aminoglycoside antibiotics in Staphlococcus aureus

29 September 2017

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Source of phosphate in the enzymic reaction as a point of distinction among aminoglycoside 2''-phosphotransferases.

29 September 2017

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Substrate specificities and structure-activity relationships for the nucleotidylation of antibiotics catalyzed by aminoglycoside nucleotidyltransferase 2''-I.

2 June 2018

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Suboptimal therapy and clinical management of gonorrhoea in an area with high-level antimicrobial resistance

2 June 2018

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Aminoglycoside 2''-phosphotransferase type IIIa from Enterococcus.

27 November 2018

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Characterization of the bifunctional aminoglycoside-modifying enzyme ANT(3'')-Ii/AAC(6')-IId from Serratia marcescens

27 November 2018

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Kinetic mechanism of streptomycin adenylyltransferase from a recombinant Escherichia coli

27 November 2018

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Kinetic mechanism of the GCN5-related chromosomal aminoglycoside acetyltransferase AAC(6')-Ii from Enterococcus faecium: evidence of dimer subunit cooperativity

27 November 2018

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Purification, characterization, and investigation of the mechanism of aminoglycoside 3'-phosphotransferase type Ia.

27 November 2018

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Kinetic studies of aminoglycoside acetyltransferase and phosphotransferase from Staphylococcus aureus RPAL. Relationship between the two activities.

27 November 2018

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Kinetic mechanism of enterococcal aminoglycoside phosphotransferase 2"-Ib

27 November 2018

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PubMed

https://pubmed.ncbi.nlm.nih.gov/20556826