Substrate specificity determinants in the farnesyltransferase beta-subunit (Q27930129)

1 December 2016

title

Substrate specificity determinants in the farnesyltransferase beta-subunit (English)

1 reference

Protein farnesyltransferase YDL090C

1 December 2016

main subject

1 reference

Proceedings of the National Academy of Sciences of the United States of America

GOA release 2020-03-11

author name string

V L Boyartchuk

series ordinal

2

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J Rine

series ordinal

3

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C E Trueblood

series ordinal

1

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language of work or name

English

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publication date

30 September 1997

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published in

1 reference

Crystal structure of protein farnesyltransferase at 2.25 angstrom resolution

1 December 2016

volume

94

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issue

20

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page(s)

10774-9

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cites work

1 reference

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20 March 2017

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20 March 2017

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Protein farnesyltransferase and geranylgeranyltransferase share a common alpha subunit

20 March 2017

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Characterization of YDJ1: a yeast homologue of the bacterial dnaJ protein

20 March 2017

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20 March 2017

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Characterization of recombinant human farnesyl-protein transferase: cloning, expression, farnesyl diphosphate binding, and functional homology with yeast prenyl-protein transferases

20 March 2017

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20 March 2017

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20 March 2017

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Mutational analysis of alpha-subunit of protein farnesyltransferase. Evidence for a catalytic role

20 March 2017

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Protein farnesyltransferase: kinetics of farnesyl pyrophosphate binding and product release

20 March 2017

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CAAX geranylgeranyl transferase transfers farnesyl as efficiently as geranylgeranyl to RhoB

20 March 2017

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20 March 2017

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Cloning and expression of a cDNA encoding the alpha subunit of rat p21ras protein farnesyltransferase

20 March 2017

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20 March 2017

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Plant farnesyltransferase can restore yeast Ras signaling and mating

22 April 2017

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Development of highly potent inhibitors of Ras farnesyltransferase possessing cellular and in vivo activity.

29 September 2017

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Evidence that farnesyltransferase inhibitors suppress Ras transformation by interfering with Rho activity

29 September 2017

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Genetic evidence for in vivo cross-specificity of the CaaX-box protein prenyltransferases farnesyltransferase and geranylgeranyltransferase-I in Saccharomyces cerevisiae

29 September 2017

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Suppression of yeast geranylgeranyl transferase I defect by alternative prenylation of two target GTPases, Rho1p and Cdc42p

29 September 2017

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Protein farnesyltransferase in plants. Molecular cloning and expression of a homolog of the beta subunit from the garden pea.

29 September 2017

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Mutant farnesyltransferase beta subunit of Saccharomyces cerevisiae that can substitute for geranylgeranyltransferase type I beta subunit

29 September 2017

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Disruption of Oncogenic K-Ras4B Processing and Signaling by a Potent Geranylgeranyltransferase I Inhibitor

29 September 2017

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29 September 2017

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A protein geranylgeranyltransferase from bovine brain: implications for protein prenylation specificity

29 September 2017

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Sequence requirement for peptide recognition by rat brain p21ras protein farnesyltransferase

29 September 2017

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Enzymatic modification of proteins with a geranylgeranyl isoprenoid

29 September 2017

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Sequence dependence of protein isoprenylation

29 September 2017

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Identification of a cysteine residue essential for activity of protein farnesyltransferase. Cys299 is exposed only upon removal of zinc from the enzyme.

29 September 2017

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A protein farnesyl transferase involved in abscisic acid signal transduction in Arabidopsis

2 June 2018

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Isoprenoid diphosphate utilization by recombinant human farnesyl:protein transferase: interactive binding between substrates and a preferred kinetic pathway.

2 June 2018

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Benzodiazepine peptidomimetics: potent inhibitors of Ras farnesylation in animal cells

2 June 2018

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Selective inhibition of ras-dependent transformation by a farnesyltransferase inhibitor

2 June 2018

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2 June 2018

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Critical role of Rho in cell transformation by oncogenic Ras.

2 June 2018

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Structure and expression of yeast DPR1, a gene essential for the processing and intracellular localization of ras proteins

2 June 2018

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2 June 2018

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2 June 2018

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Enzymatic coupling of cholesterol intermediates to a mating pheromone precursor and to the ras protein

2 June 2018

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Nonidentical subunits of p21H-ras farnesyltransferase. Peptide binding and farnesyl pyrophosphate carrier functions

2 June 2018

1 reference

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Structural homology among mammalian and Saccharomyces cerevisiae isoprenyl-protein transferases

2 June 2018

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rab GTP-binding proteins with three different carboxyl-terminal cysteine motifs are modified in vivo by 20-carbon isoprenoids

2 June 2018

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Common modifications of trimeric G proteins and ras protein: involvement of polyisoprenylation

2 June 2018

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Polylysine and CVIM sequences of K-RasB dictate specificity of prenylation and confer resistance to benzodiazepine peptidomimetic in vitro.

2 June 2018

1 reference

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Amino acid substitutions that convert the protein substrate specificity of farnesyltransferase to that of geranylgeranyltransferase type I.

21 January 2018

1 reference

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Mutational analysis of the beta-subunit of yeast geranylgeranyl transferase I.

21 January 2018

1 reference

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27 November 2018

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Bisubstrate inhibitors of farnesyltransferase: a novel class of specific inhibitors of ras transformed cells.

27 November 2018

1 reference

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Substrate characterization of the Saccharomyces cerevisiae protein farnesyltransferase and type-I protein geranylgeranyltransferase

27 November 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.94.20.10774

Inhibition of farnesyltransferase induces regression of mammary and salivary carcinomas in ras transgenic mice

21 January 2018

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Involvement of the alpha subunit of farnesyl-protein transferase in substrate recognition

21 January 2018

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Substitution of cadmium for zinc in farnesyl:protein transferase alters its substrate specificity

21 January 2018

1 reference

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Evidence for a catalytic role of zinc in protein farnesyltransferase. Spectroscopy of Co2+-farnesyltransferase indicates metal coordination of the substrate thiolate

21 January 2018

1 reference

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RAM, a gene of yeast required for a functional modification of RAS proteins and for production of mating pheromone a-factor

21 January 2018

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Design and synthesis of non-peptide Ras CAAX mimetics as potent farnesyltransferase inhibitors

21 January 2018

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21 January 2018

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Conformation of a heptapeptide substrate bound to protein farnesyltransferase

21 January 2018

1 reference

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21 January 2018

1 reference

12 December 2020

Farnesylation of YDJ1p is required for function at elevated growth temperatures in Saccharomyces cerevisiae

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Potent inhibition of human tumor p21ras farnesyltransferase by A1A2-lacking p21ras CA1A2X peptidomimetics

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Design and structural requirements of potent peptidomimetic inhibitors of p21ras farnesyltransferase

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Identifiers

DOI

10.1073/PNAS.94.20.10774

0 references

PMC publication ID

23482

0 references

1 reference