Immunoglobulin kappa light chain gene rearrangement is impaired in mice deficient for DNA polymerase mu (Q28202970)

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Annie De Smet

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Claudia Berek

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Jean-Claude Weill

Joining of immunoglobulin heavy chain gene segments: implications from a chromosome with evidence of three D-JH fusions

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language of work or name

English

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publication date

August 2003

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published in

Immunity

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volume

19

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issue

2

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page(s)

203-11

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cites work

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Two novel human and mouse DNA polymerases of the polX family

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The mechanism and regulation of chromosomal V(D)J recombination

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Cutting edge: DNA polymerases mu and lambda are dispensable for Ig gene hypermutation

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Most alpha/beta T cell receptor diversity is due to terminal deoxynucleotidyl transferase

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A targeted deletion of a region upstream from the Jkappa cluster impairs kappa chain rearrangement in cis in mice and in the 103/bcl2 cell line.

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Insertion of N regions into heavy-chain genes is correlated with expression of terminal deoxytransferase in B cells

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DNA polymerase mu (Pol mu), homologous to TdT, could act as a DNA mutator in eukaryotic cells

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Human DNA polymerase mu (Pol mu) exhibits an unusual replication slippage ability at AAF lesion

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Mismatch repair deficiency interferes with the accumulation of mutations in chronically stimulated B cells and not with the hypermutation process

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A targeted DNA-PKcs-null mutation reveals DNA-PK-independent functions for KU in V(D)J recombination

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Recent advances in understanding V(D)J recombination.

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Growth retardation and leaky SCID phenotype of Ku70-deficient mice.

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Translesion synthesis past platinum DNA adducts by human DNA polymerase mu.

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Factors and forces controlling V(D)J recombination

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The regulated expression of B lineage associated genes during B cell differentiation in bone marrow and fetal liver

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The biochemistry and biological significance of nonhomologous DNA end joining: an essential repair process in multicellular eukaryotes

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The defect in murine severe combined immune deficiency: joining of signal sequences but not coding segments in V(D)J recombination

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Hairpin opening and overhang processing by an Artemis/DNA-dependent protein kinase complex in nonhomologous end joining and V(D)J recombination

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Association of terminal deoxynucleotidyl transferase with Ku

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Association of DNA polymerase mu (pol mu) with Ku and ligase IV: role for pol mu in end-joining double-strand break repair

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Artemis, a novel DNA double-strand break repair/V(D)J recombination protein, is mutated in human severe combined immune deficiency.

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RAG-1 and RAG-2, adjacent genes that synergistically activate V(D)J recombination

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Involvement of Brca2 in DNA repair

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The chosen few? Positive selection and the generation of naive B lymphocytes

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Ku80 is required for addition of N nucleotides to V(D)J recombination junctions by terminal deoxynucleotidyl transferase

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Formation and resolution of double-strand break intermediates in V(D)J rearrangement

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Transcription, beta-like DNA polymerases and hypermutation

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DNA polymerase mu, a candidate hypermutase?

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The structural repertoire of the human V kappa domain

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Activation of immunoglobulin kappa gene rearrangement correlates with induction of germline kappa gene transcription

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Impairment of V(D)J recombination in double-strand break repair mutants

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Roles of E. coli DNA polymerases IV and V in lesion-targeted and untargeted SOS mutagenesis

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Distinct and opposite diversifying activities of terminal transferase splice variants

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Highly frequent frameshift DNA synthesis by human DNA polymerase mu

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Lesion bypass activities of human DNA polymerase mu.

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Identifiers

DOI

1 reference

Consolidated OpenCitations Corpus – April 2017

1 reference

Consolidated OpenCitations Corpus – April 2017

PubMed publication ID

12932354

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Consolidated OpenCitations Corpus – April 2017