Rho-kinase inhibitors as therapeutics: from pan inhibition to isoform selectivity (Q28264544)

Cellular and Molecular Life Sciences

Europe PubMed Central

title

Rho-kinase inhibitors as therapeutics: from pan inhibition to isoform selectivity (English)

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author name string

C Hahmann

series ordinal

1

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T Schroeter

series ordinal

2

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language of work or name

English

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publication date

January 2010

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published in

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volume

67

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issue

2

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page(s)

171-7

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cites work

Effects of protein kinase inhibitor, HA1077, on intraocular pressure and outflow facility in rabbit eyes

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Rho-kinase inhibition improves erectile function in aging male Brown-Norway rats

21 January 2018

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Improved erectile function after Rho-kinase inhibition in a rat castrate model of erectile dysfunction

21 January 2018

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Targeting of RhoA/ROCK signaling ameliorates progression of diabetic nephropathy independent of glucose control

21 January 2018

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12 December 2020

A Rho-kinase inhibitor, fasudil, prevents development of diabetes and nephropathy in insulin-resistant diabetic rats

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12 December 2020

RhoE binds to ROCK I and inhibits downstream signaling

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12 December 2020

Cytoplasmic p21(Cip1/WAF1) enhances axonal regeneration and functional recovery after spinal cord injury in rats.

1 reference

12 December 2020

ROCK-I and ROCK-II, two isoforms of Rho-associated coiled-coil forming protein serine/threonine kinase in mice

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12 December 2020

Mechanism of multi-site phosphorylation from a ROCK-I:RhoE complex structure

1 reference

12 December 2020

Targeted deletion of ROCK1 protects the heart against pressure overload by inhibiting reactive fibrosis

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12 December 2020

Benzimidazole- and benzoxazole-based inhibitors of Rho kinase

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12 December 2020

Rho kinase inhibition enhances axonal regeneration in the injured CNS.

1 reference

12 December 2020

Antagonism of Rho-kinase stimulates rat penile erection via a nitric oxide-independent pathway.

1 reference

12 December 2020

Phosphorylation of myosin-binding subunit (MBS) of myosin phosphatase by Rho-kinase in vivo

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12 December 2020

Targeted disruption of the mouse rho-associated kinase 2 gene results in intrauterine growth retardation and fetal death

1 reference

12 December 2020

A novel serine/threonine kinase binding the Ras-related RhoA GTPase which translocates the kinase to peripheral membranes

1 reference

12 December 2020

Membrane blebbing during apoptosis results from caspase-mediated activation of ROCK I.

1 reference

12 December 2020

Modulation of aqueous humor outflow facility by the Rho kinase-specific inhibitor Y-27632.

1 reference

12 December 2020

Sequence-specific knockdown of EWS-FLI1 by targeted, nonviral delivery of small interfering RNA inhibits tumor growth in a murine model of metastatic Ewing's sarcoma

1 reference

12 December 2020

Protein kinase C-related kinase and ROCK are required for thrombin-induced endothelial cell permeability downstream from Galpha12/13 and Galpha11/q

1 reference

12 December 2020

Inhibition of Rho kinases enhances the degradation of mutant huntingtin.

1 reference

12 December 2020

Proerectile effects of the Rho-kinase inhibitor (S)-(+)-2-methyl-1-[(4-methyl-5-isoquinolinyl)sulfonyl]homopiperazine (H-1152) in the rat penis

1 reference

12 December 2020

Hyaluronan stimulates transformation of androgen-independent prostate cancer

1 reference

12 December 2020

Orally delivered siRNA targeting macrophage Map4k4 suppresses systemic inflammation

1 reference

12 December 2020

Chroman-3-amides as potent Rho kinase inhibitors

1 reference

12 December 2020

Rocks: multifunctional kinases in cell behaviour

1 reference

12 December 2020

Design and synthesis of potent and selective azaindole-based Rho kinase (ROCK) inhibitors

1 reference

12 December 2020

Involvement of Rho kinase in endothelial barrier maintenance

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12 December 2020

ROCK mediates thrombin's endothelial barrier dysfunction

1 reference

12 December 2020

Rho-kinase 2 is frequently overexpressed in hepatocellular carcinoma and involved in tumor invasion.

1 reference

12 December 2020

Inhibition of Rho-kinase attenuates nephrosclerosis and improves survival in salt-loaded spontaneously hypertensive stroke-prone rats

1 reference

12 December 2020

Rho-associated kinase directly induces smooth muscle contraction through myosin light chain phosphorylation

1 reference

12 December 2020

Caspase-3-mediated cleavage of ROCK I induces MLC phosphorylation and apoptotic membrane blebbing

1 reference

12 December 2020

Rho-associated kinase ROCK activates LIM-kinase 1 by phosphorylation at threonine 508 within the activation loop

1 reference

12 December 2020

The expression and prognostic value of ROCK I and ROCK II and their role in human breast cancer

1 reference

12 December 2020

N-terminus-mediated dimerization of ROCK-I is required for RhoE binding and actin reorganization

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12 December 2020

Discovery of substituted 4-(pyrazol-4-yl)-phenylbenzodioxane-2-carboxamides as potent and highly selective Rho kinase (ROCK-II) inhibitors.

1 reference

12 December 2020

Specificity and mechanism of action of some commonly used protein kinase inhibitors

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12 December 2020

Protein kinase inhibition by fasudil hydrochloride promotes neurological recovery after spinal cord injury in rats

1 reference

12 December 2020

Nonsteroidal Anti-Inflammatory Drugs Can Lower Amyloidogenic Aß 42 by Inhibiting Rho

1 reference

12 December 2020

Reduction of intraocular pressure by topical administration of an inhibitor of the Rho-associated protein kinase

1 reference

12 December 2020

Regulation of myosin phosphatase by Rho and Rho-associated kinase (Rho-kinase)

1 reference

12 December 2020

Signaling from Rho to the actin cytoskeleton through protein kinases ROCK and LIM-kinase

1 reference

12 December 2020

Y-27632 prevents tubulointerstitial fibrosis in mouse kidneys with unilateral ureteral obstruction

1 reference

12 December 2020

Activation of RhoA by thrombin in endothelial hyperpermeability: role of Rho kinase and protein tyrosine kinases

1 reference

12 December 2020

Inhibition of intrahepatic metastasis of human hepatocellular carcinoma by Rho-associated protein kinase inhibitor Y-27632.

1 reference

12 December 2020

Effects of the Rho kinase inhibitor Y-27632 and the phosphatase inhibitor calyculin A on outflow facility in monkeys

1 reference

12 December 2020

Wf-536 prevents tumor metastasis by inhibiting both tumor motility and angiogenic actions

1 reference

12 December 2020

Effects of topical administration of y-39983, a selective rho-associated protein kinase inhibitor, on ocular tissues in rabbits and monkeys

1 reference

12 December 2020

The small GTP-binding protein Rho binds to and activates a 160 kDa Ser/Thr protein kinase homologous to myotonic dystrophy kinase

1 reference

12 December 2020

Rho-kinase inhibitor retards migration and in vivo dissemination of human prostate cancer cells

1 reference

12 December 2020

Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension

1 reference

12 December 2020

Phosphorylation and activation of myosin by Rho-associated kinase (Rho-kinase)

1 reference

12 December 2020

Rho-kinase as a molecular target for insulin resistance and hypertension

1 reference

12 December 2020

Significant association of Rho/ROCK pathway with invasion and metastasis of bladder cancer

1 reference

12 December 2020

Specific activation of LIM kinase 2 via phosphorylation of threonine 505 by ROCK, a Rho-dependent protein kinase

1 reference

12 December 2020

Effect of fasudil on Rho-kinase and nephropathy in subtotally nephrectomized spontaneously hypertensive rats

1 reference

12 December 2020

Possible involvement of Rho-kinase in the pathogenesis of hypertension in humans

1 reference

12 December 2020

Cardiovascular effects of a novel potent and highly selective azaindole-based inhibitor of Rho-kinase

1 reference

12 December 2020

Pharmacological characterization of SAR407899, a novel rho-kinase inhibitor

1 reference

12 December 2020

Identification of ROCK1 as an upstream activator of the JIP-3 to JNK signaling axis in response to UVB damage

1 reference

12 December 2020

ROCK1 and LIMK2 interact in spread but not blebbing cancer cells

1 reference

12 December 2020

Comparative gene expression profiling in three primary human cell lines after treatment with a novel inhibitor of Rho kinase or atorvastatin

1 reference

12 December 2020

Discovery of aminofurazan-azabenzimidazoles as inhibitors of Rho-kinase with high kinase selectivity and antihypertensive activity

1 reference

12 December 2020

The Rho kinase inhibitor fasudil inhibits tumor progression in human and rat tumor models

1 reference

12 December 2020

ROCK-I and ROCK-II cooperatively regulate closure of eyelid and ventral body wall in mouse embryo

1 reference

12 December 2020

Roles of Rho/ROCK and MLCK in TNF-α-induced changes in endothelial morphology and permeability

1 reference

12 December 2020

Effect of Wf-536, a novel ROCK inhibitor, against metastasis of B16 melanoma

1 reference

12 December 2020

Phosphorylation of adducin by Rho-kinase plays a crucial role in cell motility

1 reference

12 December 2020

Decreased intraocular pressure in mice following either pharmacological or genetic inhibition of ROCK.

1 reference

12 December 2020

Rho kinase polymorphism influences blood pressure and systemic vascular resistance in human twins: role of heredity

1 reference

12 December 2020

Fasudil attenuates interstitial fibrosis in rat kidneys with unilateral ureteral obstruction

1 reference

12 December 2020

Intraocular pressure-lowering effects and safety of topical administration of a selective ROCK inhibitor, SNJ-1656, in healthy volunteers

1 reference

12 December 2020

ROCK isoform regulation of myosin phosphatase and contractility in vascular smooth muscle cells

1 reference

12 December 2020

Acute vasodilator effects of a Rho-kinase inhibitor, fasudil, in patients with severe pulmonary hypertension

1 reference

12 December 2020

Effects of rho-associated protein kinase inhibitor Y-27632 on intraocular pressure and outflow facility

1 reference

12 December 2020

In vivo imaging of siRNA delivery and silencing in tumors

1 reference

12 December 2020

Rho-associated kinase, a novel serine/threonine kinase, as a putative target for small GTP binding protein Rho

1 reference

12 December 2020

ROCK-I regulates closure of the eyelids and ventral body wall by inducing assembly of actomyosin bundles

1 reference

12 December 2020

Transvascular delivery of small interfering RNA to the central nervous system.

1 reference

12 December 2020

Rock2 controls TGFbeta signaling and inhibits mesoderm induction in zebrafish embryos

1 reference

12 December 2020

Thrombin-induced endothelial barrier disruption in intact microvessels: role of RhoA/Rho kinase-myosin phosphatase axis.

1 reference

12 December 2020

Development of dihydropyridone indazole amides as selective Rho-kinase inhibitors

1 reference

12 December 2020

ROCK-II mediates colon cancer invasion via regulation of MMP-2 and MMP-13 at the site of invadopodia as revealed by multiphoton imaging

1 reference

12 December 2020

Direct cleavage of ROCK II by granzyme B induces target cell membrane blebbing in a caspase-independent manner.

1 reference

12 December 2020

The Rho kinases I and II regulate different aspects of myosin II activity

1 reference

12 December 2020

Rho kinase and matrix metalloproteinase inhibitors cooperate to inhibit angiogenesis and growth of human prostate cancer xenotransplants

1 reference

12 December 2020

Decreased perivascular fibrosis but not cardiac hypertrophy in ROCK1+/- haploinsufficient mice

1 reference

12 December 2020

Rho-kinase phosphorylates COOH-terminal threonines of ezrin/radixin/moesin (ERM) proteins and regulates their head-to-tail association

1 reference

12 December 2020

Regulation of endothelial junctional permeability

1 reference

12 December 2020

A major haplotype block at the rho-associated kinase 2 locus is associated with a lower risk of hypertension in a recessive manner: the HYPGENE study

1 reference

12 December 2020

Fasudil, a Rho-kinase inhibitor, attenuates glomerulosclerosis in Dahl salt-sensitive rats

1 reference

12 December 2020

Dose-dependent beneficial and detrimental effects of ROCK inhibitor Y27632 on axonal sprouting and functional recovery after rat spinal cord injury

1 reference

12 December 2020