Twenty-five years since the discovery of endothelium-derived relaxing factor (EDRF): does a dysfunctional endothelium contribute to the development of type 2 diabetes? (Q30352122)

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English	Twenty-five years since the discovery of endothelium-derived relaxing factor (EDRF): does a dysfunctional endothelium contribute to the development of type 2 diabetes?	scientific article

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scholarly article

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10 January 2020

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Europe PubMed Central

Twenty-five years since the discovery of endothelium-derived relaxing factor (EDRF): does a dysfunctional endothelium contribute to the development of type 2 diabetes? (English)

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Europe PubMed Central

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10 January 2020

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type 2 diabetes

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based on heuristic

inferred from title

Chris R Triggle

1

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Europe PubMed Central

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10 January 2020

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Andrew Howarth

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10 January 2020

Zhong Jian Cheng

3

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10 January 2020

Hong Ding

4

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1 August 2005

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10 January 2020

Canadian Journal of Physiology and Pharmacology

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10 January 2020

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10 January 2020

8-9

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10 January 2020

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10 January 2020

Adipose-selective targeting of the GLUT4 gene impairs insulin action in muscle and liver

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Ceramide content is increased in skeletal muscle from obese insulin-resistant humans

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21 January 2018

Endothelium-derived C-type natriuretic peptide: more than just a hyperpolarizing factor

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21 January 2018

Advanced glycation endproducts--role in pathology of diabetic complications

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21 January 2018

The coming of age of the metabolic syndrome.

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21 January 2018

Regulation of endothelial nitric oxide synthase by tetrahydrobiopterin in vascular disease

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21 January 2018

Increased endothelial tetrahydrobiopterin synthesis by targeted transgenic GTP-cyclohydrolase I overexpression reduces endothelial dysfunction and atherosclerosis in ApoE-knockout mice

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21 January 2018

Low-density lipoproteins inhibit endothelium-dependent relaxation in rabbit aorta.

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21 January 2018

The vascular endothelium in diabetes: a practical target for drug treatment?

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21 January 2018

The role of diet in the prevention and treatment of hypertension

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21 January 2018

Developmental programming of the metabolic syndrome by maternal nutritional imbalance: how strong is the evidence from experimental models in mammals?

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21 January 2018

Developmental programming of aortic and renal structure in offspring of rats fed fat-rich diets in pregnancy

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21 January 2018

Microvascular dysfunction after transient high glucose is caused by superoxide-dependent reduction in the bioavailability of NO and BH(4).

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21 January 2018

The intrauterine origins of cardiovascular disease

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21 January 2018

Insulin-mediated skeletal muscle vasodilation contributes to both insulin sensitivity and responsiveness in lean humans

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21 January 2018

Inhibition of protein kinase Cbeta prevents impaired endothelium-dependent vasodilation caused by hyperglycemia in humans

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21 January 2018

PPARs: therapeutic targets for metabolic disease

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21 January 2018

Aldose reductase: congenial and injurious profiles of an enigmatic enzyme

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21 January 2018

Adipose tissue selective insulin receptor knockout protects against obesity and obesity-related glucose intolerance

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21 January 2018

Measurement of subclinical atherosclerosis: beyond risk factor assessment

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21 January 2018

Pathogenesis of type 2 diabetes. Insulin resistance

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21 January 2018

Free fatty acids in obesity and type 2 diabetes: defining their role in the development of insulin resistance and beta-cell dysfunction.

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21 January 2018

Mechanisms for early microvascular injury in obesity and type II diabetes

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21 January 2018

Obesity lowers hyperglycemic threshold for impaired in vivo endothelial nitric oxide function

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21 January 2018

Multiple mechanisms of early hyperglycaemic injury of the rat intestinal microcirculation

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21 January 2018

Prevention and reversal of premature endothelial cell senescence and vasculopathy in obesity-induced diabetes by ebselen

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21 January 2018

Aminoguanidine prevents diabetes-induced arterial wall protein cross-linking

1 reference

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21 January 2018

Augmented BH4 by gene transfer restores nitric oxide synthase function in hyperglycemic human endothelial cells

1 reference

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21 January 2018

Inhibition and stimulation of nitric oxide synthesis in the human forearm arterial bed of patients with insulin-dependent diabetes

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21 January 2018

Insulin generates free radicals by an NAD(P)H, phosphatidylinositol 3'-kinase-dependent mechanism in human skin fibroblasts ex vivo.

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21 January 2018

Postprandial hyperglycemia and diabetes complications: is it time to treat?

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21 January 2018

A role for ceramide, but not diacylglycerol, in the antagonism of insulin signal transduction by saturated fatty acids

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21 January 2018

Nitric oxide production and regulation of endothelial nitric-oxide synthase phosphorylation by prolonged treatment with troglitazone: evidence for involvement of peroxisome proliferator-activated receptor (PPAR) gamma-dependent and PPARgamma-indepen

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21 January 2018

The vasodilatory actions of insulin on resistance and terminal arterioles and their impact on muscle glucose uptake

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21 January 2018

Importance of advanced glycation end products in diabetes-associated cardiovascular and renal disease

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21 January 2018

Reactive oxygen species mediate endothelium-dependent relaxations in tetrahydrobiopterin-deficient mice

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21 January 2018

High glucose causes upregulation of cyclooxygenase-2 and alters prostanoid profile in human endothelial cells: role of protein kinase C and reactive oxygen species

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21 January 2018

Diabetes and vascular disease: pathophysiology, clinical consequences, and medical therapy: Part I.

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21 January 2018

Endothelial dysfunction in diabetes.

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21 January 2018

The double puzzle of diabetes

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21 January 2018

Endothelial cell dysfunction and the vascular complications associated with type 2 diabetes: assessing the health of the endothelium

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21 January 2018

Potassium- and acetylcholine-induced vasorelaxation in mice lacking endothelial nitric oxide synthase

1 reference

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21 January 2018

Endothelial dysfunction in Type 2 diabetes correlates with deregulated expression of the tail-anchored membrane protein SLMAP.

1 reference

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21 January 2018

Insulin resistance, hyperlipidemia, and hypertension in mice lacking endothelial nitric oxide synthase

1 reference

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21 January 2018

The metabolic syndrome

1 reference

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21 January 2018

Endothelium-derived reactive oxygen species: their relationship to endothelium-dependent hyperpolarization and vascular tone.

1 reference

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21 January 2018

Insulin-dependent activation of endothelial nitric oxide synthase is impaired by O-linked glycosylation modification of signaling proteins in human coronary endothelial cells

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21 January 2018

Insulin enhances the expression of the endothelial nitric oxide synthase in native endothelial cells: a dual role for Akt and AP-1.

1 reference

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21 January 2018

Advanced glycation end product interventions reduce diabetes-accelerated atherosclerosis.

1 reference

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21 January 2018

The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine

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21 January 2018

Physiology of the endothelium

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21 January 2018

Characterisation of glucose transporters in the intact coronary artery endothelium in rats: GLUT-2 upregulated by long-term hyperglycaemia

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21 January 2018

Abnormal aortic fatty acid composition and small artery function in offspring of rats fed a high fat diet in pregnancy

1 reference

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Effects of prior moderate exercise on postprandial metabolism and vascular function in lean and centrally obese men.

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21 January 2018

Redox paradox: insulin action is facilitated by insulin-stimulated reactive oxygen species with multiple potential signaling targets

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21 January 2018

Glucose levels observed in daily clinical practice induce endothelial dysfunction in the rabbit macro- and microcirculation

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21 January 2018

Endothelium-dependent smooth muscle hyperpolarization: do gap junctions provide a unifying hypothesis?

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21 January 2018

Mortality from coronary heart disease in subjects with type 2 diabetes and in nondiabetic subjects with and without prior myocardial infarction

1 reference

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21 January 2018

Early programming of glucose-insulin metabolism

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21 January 2018

The dangerous road of catch-up growth.

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21 January 2018

Exercise as a therapeutic intervention for the prevention and treatment of insulin resistance

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21 January 2018

Active and passive mechanical properties of isolated arterioles from STZ-induced diabetic rats. Effect of aminoguanidine treatment

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21 January 2018

Hyperglycemia without hyperinsulinemia produces both sympathetic neural activation and vasodilation in normal humans.

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21 January 2018

RAGE: a novel target for drug intervention in diabetic vascular disease

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21 January 2018

Tetrahydrobiopterin restores endothelial dysfunction induced by an oral glucose challenge in healthy subjects

1 reference

https://api.crossref.org/works/10.1139%2FY05-069

21 January 2018

Protein kinase C activation and its role in the development of vascular complications in diabetes mellitus

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21 January 2018

Nutrition and pregnancy: the link between dietary intake and diabetes

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21 January 2018

Expression of nitric oxide synthase in skeletal muscle: a novel role for nitric oxide as a modulator of insulin action

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21 January 2018

Senescence Induced by Altered Telomere State, Not Telomere Loss

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21 January 2018

Hyperglycemia rapidly suppresses flow-mediated endothelium-dependent vasodilation of brachial artery.

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21 January 2018

Muscle triglyceride and insulin resistance

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21 January 2018

Gender-linked hypertension in offspring of lard-fed pregnant rats

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21 January 2018

Effects of acute glucose overload on histamine H2 receptor-mediated Ca2+ mobilization in bovine cerebral endothelial cells

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21 January 2018

The role of lipid accumulation in liver and muscle for insulin resistance and type 2 diabetes mellitus in humans

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21 January 2018

High glucose induces alteration of gap junction permeability and phosphorylation of connexin-43 in cultured aortic smooth muscle cells

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21 January 2018

Hyperglycemia as a risk factor for cardiovascular disease in type 2 diabetes

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21 January 2018

Decreased effect of insulin to stimulate skeletal muscle blood flow in obese man. A novel mechanism for insulin resistance

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21 January 2018

Impaired insulin-mediated skeletal muscle blood flow in patients with NIDDM.

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21 January 2018

Endothelial dysfunction accompanies a pro-oxidant, pro-diabetic challenge in the insulin resistant, obese Zucker rat in vivo.

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21 January 2018

Rosiglitazone enhances glucose tolerance by mechanisms other than reduction of fatty acid accumulation within skeletal muscle

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21 January 2018

Elevated glucose impairs cAMP-mediated dilation by reducing Kv channel activity in rat small coronary smooth muscle cells

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21 January 2018

Nitration and functional loss of voltage-gated K+ channels in rat coronary microvessels exposed to high glucose

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21 January 2018

Diabetic macrovascular disease: the glucose paradox?

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21 January 2018

Dietary glycemic load and atherothrombotic risk

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21 January 2018

High glucose impairs voltage-gated K(+) channel current in rat small coronary arteries

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21 January 2018

Peroxynitrite inhibits Ca2+-activated K+ channel activity in smooth muscle of human coronary arterioles

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21 January 2018

Nutrition and the endothelium

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21 January 2018

The metabolic syndrome as predictor of type 2 diabetes: the San Antonio heart study

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21 January 2018

Regulation of endothelial nitric oxide synthase by protein kinase C.

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21 January 2018

Membrane depolarization and NADPH oxidase activation in aortic endothelium during ischemia reflect altered mechanotransduction

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21 January 2018

Insulin's stimulation of endothelial superoxide generation may reflect up-regulation of isoprenyl transferase activity that promotes rac translocation

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21 January 2018

Banting lecture 2001: dysregulation of fatty acid metabolism in the etiology of type 2 diabetes

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21 January 2018

Boxing and the brain. Revisiting chronic traumatic encephalopathy.

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21 January 2018

Effects of glucose and insulin on the development of oxidative stress and hypertension in animal models of type 1 and type 2 diabetes

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21 January 2018

Role of telomere in endothelial dysfunction in atherosclerosis

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21 January 2018

An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation

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21 January 2018

Insulin-stimulated activation of eNOS is independent of Ca2+ but requires phosphorylation by Akt at Ser(1179).

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21 January 2018

Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage

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21 January 2018

Tetrahydrobiopterin increases insulin sensitivity in patients with type 2 diabetes and coronary heart disease

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21 January 2018

Acute hyperglycemia and hyperinsulinemia enhance vasodilatation in Type 1 diabetes mellitus without increasing capillary permeability and inducing endothelial dysfunction

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21 January 2018

Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor

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21 January 2018

Skeletal muscle triglyceride levels are inversely related to insulin action.

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21 January 2018

Cellular basis of endothelial dysfunction in small mesenteric arteries from spontaneously diabetic (db/db -/-) mice: role of decreased tetrahydrobiopterin bioavailability

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21 January 2018

Enhanced vascular reactivity of small mesenteric arteries from diabetic mice is associated with enhanced oxidative stress and cyclooxygenase products

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21 January 2018

Intramyocellular triglyceride content is a determinant of in vivo insulin resistance in humans: a 1H-13C nuclear magnetic resonance spectroscopy assessment in offspring of type 2 diabetic parents.

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21 January 2018

The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus

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21 January 2018

Insulin induces the release of vasodilator compounds from platelets by a nitric oxide-G kinase-VAMP-3-dependent pathway

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21 January 2018

A high-fat, refined-carbohydrate diet affects renal NO synthase protein expression and salt sensitivity

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21 January 2018

A high-fat, refined-carbohydrate diet induces endothelial dysfunction and oxidant/antioxidant imbalance and depresses NOS protein expression

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21 January 2018

Mechanism of free fatty acid-induced insulin resistance in humans

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21 January 2018

Decreased muscle glucose transport/phosphorylation is an early defect in the pathogenesis of non-insulin-dependent diabetes mellitus

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21 January 2018

Nitric oxide, an iceberg in cardiovascular physiology: far beyond vessel tone control

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21 January 2018

Endothelium-dependent contractile actions of proteinase-activated receptor-2-activating peptides in human umbilical vein: release of a contracting factor via a novel receptor

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21 January 2018

High glucose inhibits insulin-stimulated nitric oxide production without reducing endothelial nitric-oxide synthase Ser1177 phosphorylation in human aortic endothelial cells.

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21 January 2018

Factors, fiction and endothelium-derived hyperpolarizing factor.

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21 January 2018

Downregulation of connexin 43 expression by high glucose reduces gap junction activity in microvascular endothelial cells.

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21 January 2018

Mechanisms of insulin resistance in humans and possible links with inflammation

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21 January 2018

Nitric oxide release accounts for insulin's vascular effects in humans

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21 January 2018

Acetylcholine-induced relaxation of rabbit basilar artery in vitro is rapidly reduced by reactive oxygen species in acute hyperglycemia: role of NADPH oxidase

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21 January 2018

Mice with gene disruption of both endothelial and neuronal nitric oxide synthase exhibit insulin resistance.

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21 January 2018

Cellular mechanisms of insulin resistance

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21 January 2018

Quantitation of muscle glycogen synthesis in normal subjects and subjects with non-insulin-dependent diabetes by 13C nuclear magnetic resonance spectroscopy.

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21 January 2018

Selective pharmacological inhibition of distinct nitric oxide synthase isoforms

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21 January 2018

Nobel prize awarded to scientists for nitric oxide discoveries

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21 January 2018

Hyperglycaemia-induced superoxide production decreases eNOS expression via AP-1 activation in aortic endothelial cells

1 reference

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21 January 2018

Role of aldose reductase and oxidative damage in diabetes and the consequent potential for therapeutic options

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21 January 2018

Relationship between insulin sensitivity and sphingomyelin signaling pathway in human skeletal muscle

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21 January 2018

Increased glucose uptake promotes oxidative stress and PKC-delta activation in adipocytes of obese, insulin-resistant mice

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21 January 2018

Acute effects of glucose and insulin on vascular endothelium

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21 January 2018

The effect of hyperglycaemia on function of rat isolated mesenteric resistance artery

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21 January 2018

Impaired EDHF-mediated vasodilatation in adult offspring of rats exposed to a fat-rich diet in pregnancy.

1 reference

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21 January 2018

Impaired glucose homeostasis and mitochondrial abnormalities in offspring of rats fed a fat-rich diet in pregnancy

1 reference

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21 January 2018

Elevated glucose impairs endothelium-dependent relaxation by activating protein kinase C.

1 reference

https://api.crossref.org/works/10.1139%2FY05-069

21 January 2018

Use of aminoguanidine (Pimagedine) to prevent the formation of advanced glycation endproducts

1 reference

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21 January 2018

The endothelium in health and disease--a target for therapeutic intervention

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21 January 2018

Oxidative stress is associated with adiposity and insulin resistance in men.

1 reference

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21 January 2018

Acute hyperglycaemia in the forearm induces vasodilation that is not modified by hyperinsulinaemia.

1 reference

https://api.crossref.org/works/10.1139%2FY05-069

21 January 2018

Endothelium-dependent hyperpolarizations: the history

1 reference

https://api.crossref.org/works/10.1139%2FY05-069

21 January 2018

Endothelium-dependent contractions in hypertension

1 reference

https://api.crossref.org/works/10.1139%2FY05-069

21 January 2018

The role of endothelial insulin signaling in the regulation of vascular tone and insulin resistance

1 reference

https://api.crossref.org/works/10.1139%2FY05-069

21 January 2018

Skeletal muscle microvascular recruitment by physiological hyperinsulinemia precedes increases in total blood flow

1 reference

https://api.crossref.org/works/10.1139%2FY05-069

21 January 2018

Fish intake and risk of incident atrial fibrillation

1 reference

https://api.crossref.org/works/10.1139%2FY05-069

21 January 2018

The diet-heart hypothesis: a critique

1 reference

https://api.crossref.org/works/10.1139%2FY05-069

21 January 2018

Proteomic approaches to analyze the dynamic relationships between nucleocytoplasmic protein glycosylation and phosphorylation

1 reference

https://api.crossref.org/works/10.1139%2FY05-069

21 January 2018

The pro-oxidant role of methylglyoxal in mesenteric artery smooth muscle cells

1 reference

https://api.crossref.org/works/10.1139%2FY05-069

21 January 2018

The voltage-gated potassium channel Kv1.3 regulates peripheral insulin sensitivity

1 reference

https://api.crossref.org/works/10.1139%2FY05-069

21 January 2018

Inhibition of postprandial hyperglycemia by acarbose is a promising therapeutic strategy for the treatment of patients with the metabolic syndrome

1 reference

https://api.crossref.org/works/10.1139%2FY05-069

21 January 2018

A novel potent vasoconstrictor peptide produced by vascular endothelial cells

1 reference

https://api.crossref.org/works/10.1139%2FY05-069

21 January 2018

Dietary fat-induced increase in blood pressure and insulin resistance in rats.

1 reference

https://api.crossref.org/works/10.1139%2FY05-069

21 January 2018

Insulin-stimulated production of nitric oxide is inhibited by wortmannin. Direct measurement in vascular endothelial cells

1 reference

https://api.crossref.org/works/10.1139%2FY05-069

21 January 2018

Roles for insulin receptor, PI3-kinase, and Akt in insulin-signaling pathways related to production of nitric oxide in human vascular endothelial cells

1 reference

https://api.crossref.org/works/10.1139%2FY05-069

21 January 2018

Global and societal implications of the diabetes epidemic

1 reference

https://api.crossref.org/works/10.1139%2FY05-069

21 January 2018

Targeted disruption of the glucose transporter 4 selectively in muscle causes insulin resistance and glucose intolerance.

1 reference

https://api.crossref.org/works/10.1139%2FY05-069

21 January 2018

Endothelial Progenitor Cell Dysfunction: A Novel Concept in the Pathogenesis of Vascular Complications of Type 1 Diabetes

1 reference

https://api.crossref.org/works/10.1139%2FY05-069

21 January 2018

Type 2 (non-insulin-dependent) diabetes mellitus, hypertension and hyperlipidaemia (syndrome X): relation to reduced fetal growth

1 reference

https://api.crossref.org/works/10.1139%2FY05-069

21 January 2018

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