A functional Tph2 C1473G polymorphism causes an anxiety phenotype via compensatory changes in the serotonergic system (Q30521113)

12 August 2017

A functional Tph2 C1473G polymorphism causes an anxiety phenotype via compensatory changes in the serotonergic system (English)

1 reference

12 August 2017

1 reference

Miriam A Vogt

4

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Sarah E Gartside

object named as

Sarah E Gartside

5

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author name string

Stefan M Berger

1

1 reference

12 August 2017

Tillmann Weber

2

1 reference

12 August 2017

Stephanie Perreau-Lenz

3

1 reference

12 August 2017

Christiane Maser-Gluth

6

1 reference

12 August 2017

Laurence Lanfumey

7

1 reference

12 August 2017

Peter Gass

8

1 reference

12 August 2017

Rainer Spanagel

9

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12 August 2017

Dusan Bartsch

10

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12 August 2017

language of work or name

English

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publication date

11 April 2012

1 reference

12 August 2017

Neuropsychopharmacology

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12 August 2017

37

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12 August 2017

9

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12 August 2017

1986-1998

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Deficient serotonin neurotransmission and depression-like serotonin biomarker alterations in tryptophan hydroxylase 2 (Tph2) loss-of-function mice

12 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3398728

Serotonin-1A autoreceptors are necessary and sufficient for the normal formation of circuits underlying innate anxiety

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3398728

Tryptophan hydroxylase-2 (TPH2) in disorders of cognitive control and emotion regulation: a perspective.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3398728

Deletion of Running-Induced Hippocampal Neurogenesis by Irradiation Prevents Development of an Anxious Phenotype in Mice

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3398728

Anxiety and depression in children and adults: influence of serotonergic and neurotrophic genes?

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3398728

Tryptophan hydroxylase 2 genotype determines brain serotonin synthesis but not tissue content in C57Bl/6 and BALB/c congenic mice

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3398728

Strain differences in stress responsivity are associated with divergent amygdala gene expression and glutamate-mediated neuronal excitability

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3398728

5-HT1A autoreceptor levels determine vulnerability to stress and response to antidepressants

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3398728

Risk-taking behavior in a gambling task associated with variations in the tryptophan hydroxylase 2 gene: relevance to psychiatric disorders

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3398728

Conserved role for the serotonin transporter gene in rat and mouse neurobehavioral endophenotypes.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3398728

Growth retardation and altered autonomic control in mice lacking brain serotonin

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3398728

Functional properties of missense variants of human tryptophan hydroxylase 2.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3398728

Effects of HTR1A C(-1019)G on amygdala reactivity and trait anxiety

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3398728

Emotion and cognition in high and low stress sensitive mouse strains: a combined neuroendocrine and behavioral study in BALB/c and C57BL/6J mice.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3398728

Role of GSK3 beta in behavioral abnormalities induced by serotonin deficiency

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3398728

Targeting the murine serotonin transporter: insights into human neurobiology.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3398728

Anxiety as a developmental disorder

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3398728

No association between a TPH2 promoter polymorphism and mood disorders or monoamine turnover

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3398728

Tryptophan hydroxylase-2 gene variation influences personality traits and disorders related to emotional dysregulation.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3398728

The interaction between TPH2 promoter haplotypes and clinical-demographic risk factors in suicide victims with major psychoses.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3398728

Learned helplessness: validity and reliability of depressive-like states in mice.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3398728

Amygdala responsiveness is modulated by tryptophan hydroxylase-2 gene variation.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3398728

A regulatory variant of the human tryptophan hydroxylase-2 gene biases amygdala reactivity

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3398728

Association study of a monoamine oxidase a gene promoter polymorphism with major depressive disorder and antidepressant response

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3398728

Recent advances in animal models of chronic antidepressant effects: the novelty-induced hypophagia test

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3398728

Loss-of-function mutation in tryptophan hydroxylase-2 identified in unipolar major depression

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3398728

Single nucleotide polymorphism and haplotype analysis of a novel tryptophan hydroxylase isoform (TPH2) gene in suicide victims

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3398728

SNP and haplotype analysis of a novel tryptophan hydroxylase isoform (TPH2) gene provide evidence for association with major depression

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3398728

Relative and absolute strength of response as a function of frequency of reinforcement

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3398728

A systematic review of association studies investigating genes coding for serotonin receptors and the serotonin transporter: I. Affective disorders.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3398728

Synthesis of serotonin by a second tryptophan hydroxylase isoform

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3398728

Behavioral and physiological mouse assays for anxiety: a survey in nine mouse strains

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3398728

Role of serotonergic and noradrenergic systems in the pathophysiology of depression and anxiety disorders

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3398728

Central 5-HT(1A) receptors: regional distribution and functional characteristics

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3398728

Differential adaptation of brain 5-HT1A and 5-HT1B receptors and 5-HT transporter in rats treated chronically with fluoxetine

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3398728

Serotonin and drug-induced therapeutic responses in major depression, obsessive-compulsive and panic disorders

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3398728

Validity, reliability and utility of the chronic mild stress model of depression: a 10-year review and evaluation

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3398728

Current advances and trends in the treatment of depression

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3398728

Serotonin in panic disorder and social phobia

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3398728

Stressor-provoked behavioral changes in six strains of mice

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3398728

Characterization of 8-OH-DPAT-induced hypothermia in mice as a 5-HT1A autoreceptor response and its evaluation as a model to selectively identify antidepressants

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3398728

An autoradiographic analysis of the differential ascending projections of the dorsal and median raphe nuclei in the rat

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3398728

Strain differences in basal and post-citalopram extracellular 5-HT in the mouse medial prefrontal cortex and dorsal hippocampus: relation with tryptophan hydroxylase-2 activity

20 June 2018

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2012.46

Genotype-dependent activity of tryptophan hydroxylase-2 determines the response to citalopram in a mouse model of depression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2012.46

Strain-dependent antidepressant-like effects of citalopram in the mouse tail suspension test

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2012.46

Glutamate receptors on dopamine neurons control the persistence of cocaine seeking.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2012.46

Neurochemical and behavioral alterations in glucocorticoid receptor-impaired transgenic mice after chronic mild stress.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2012.46

Lack of association of TPH2 exon XI polymorphisms with major depression and treatment resistance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2012.46

Differences in anxiety-related behaviours and in sensitivity to diazepam in inbred and outbred strains of mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2012.46

Serotonin1A receptor acts during development to establish normal anxiety-like behaviour in the adult

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2012.46

Genetic architecture of the human tryptophan hydroxylase 2 Gene: existence of neural isoforms and relevance for major depression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2012.46

An mTph2 SNP gives rise to alterations in extracellular 5-HT levels, but not in performance on a delayed-reinforcement task

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2012.46

Insensitivity of NMRI mice to selective serotonin reuptake inhibitors in the tail suspension test can be reversed by co-treatment with 5-hydroxytryptophan

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2012.46

Glucocorticoid receptor antagonists hasten and augment neurochemical responses to a selective serotonin reuptake inhibitor antidepressant

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2012.46

Effect of SNP at position 40237 in exon 7 of the TPH2 gene on susceptibility to suicide

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2012.46

Nested association between genetic variation in tryptophan hydroxylase II, bipolar affective disorder, and suicide attempts

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2012.46

Strain differences in sucrose preference and in the consequences of unpredictable chronic mild stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2012.46

Association between a polymorphism in the promoter region of the TPH2 gene and the personality trait of harm avoidance

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2012.46

Mouse tryptophan hydroxylase isoform 2 and the role of proline 447 in enzyme function

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2012.46

Reduced sensitivity to reward in CB1 knockout mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2012.46

The mTPH2 C1473G single nucleotide polymorphism is not responsible for behavioural differences between mouse strains

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2012.46

Association of brain-specific tryptophan hydroxylase, TPH2, with unipolar and bipolar disorder in a Northern Swedish, isolated population

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2012.46

Tryptophan hydroxylase-2 controls brain serotonin synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2012.46

Haplotype-based linkage of tryptophan hydroxylase 2 to suicide attempt, major depression, and cerebrospinal fluid 5-hydroxyindoleacetic acid in 4 populations

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2012.46

Growth analysis of the mouse adrenal gland from weaning to adulthood: time- and gender-dependent alterations of cell size and number in the cortical compartment

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3398728

Effects of acute and long-term administration of escitalopram and citalopram on serotonin neurotransmission: an in vivo electrophysiological study in rat brain

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3398728

Pharmacotherapy of generalized anxiety disorder

26 November 2018

1 reference

12 December 2020

Quantitative autoradiographic characterisation of the binding of [3H]WAY-100635, a selective 5-HT1A receptor antagonist

1 reference

12 December 2020

SNP- and haplotype analysis of the tryptophan hydroxylase 2 gene in alcohol-dependent patients and alcohol-related suicide

1 reference

12 December 2020

Altered expression and functions of serotonin 5-HT1Aand 5-HT1Breceptors in knock-out mice lacking the 5-HT transporter

1 reference

12 December 2020

Effect of tryptophan hydroxylase-2 gene variants on suicide risk in major depression

1 reference

12 December 2020

Practice guideline for the treatment of patients with major depressive disorder (revision). American Psychiatric Association

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12 December 2020

Role of serotonergic and noradrenergic systems in the pathophysiology of depression and anxiety disorders

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2012.46

7 January 2021

inferred from DOI database lookup

Identifiers

DOI

10.1038/NPP.2012.46

1 reference

Dimensions Publication ID

12 August 2017

0 references

1 reference

12 August 2017

PubMed publication ID

22491354

1 reference