How Na+ activates thrombin--a review of the functional and structural data (Q33382168)

26 July 2017

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title

How Na+ activates thrombin--a review of the functional and structural data (English)

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26 July 2017

James A Huntington

1

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26 July 2017

publication date

1 August 2008

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26 July 2017

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26 July 2017

volume

389

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26 July 2017

issue

8

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26 July 2017

page(s)

1025-1035

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Important role of the cys-191 cys-220 disulfide bond in thrombin function and allostery

26 July 2017

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2939320

Thrombin as procoagulant and anticoagulant

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2939320

Thrombin-cofactor interactions: structural insights into regulatory mechanisms

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2939320

The structure of thrombin: a janus-headed proteinase

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2939320

An overview of the structure and function of thrombin

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2939320

What does it take to make the perfect clot?

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2939320

Crystal structure of wild-type human thrombin in the Na+-free state.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2939320

Positive feedbacks of coagulation: their role in threshold regulation

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2939320

Molecular recognition mechanisms of thrombin

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2939320

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2939320

Effect of Na+ binding on the conformation, stability and molecular recognition properties of thrombin

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2939320

Redesigning the monovalent cation specificity of an enzyme

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2939320

The molecular basis of thrombin allostery revealed by a 1.8 A structure of the "slow" form

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2939320

Mutation of W215 compromises thrombin cleavage of fibrinogen, but not of PAR-1 or protein C.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2939320

Molecular mechanisms of thrombin function

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2939320

The molecular environment of the Na+ binding site of thrombin

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2939320

Residue 225 determines the Na(+)-induced allosteric regulation of catalytic activity in serine proteases

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2939320

The isomorphous structures of prethrombin2, hirugen-, and PPACK-thrombin: changes accompanying activation and exosite binding to thrombin

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2939320

An allosteric switch controls the procoagulant and anticoagulant activities of thrombin

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2939320

Identification of residues linked to the slow-->fast transition of thrombin

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2939320

Conversion of thrombin into an anticoagulant by protein engineering

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2939320

Effects of sodium and lithium salts on the conformation of human alpha-thrombin

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2939320

On the size of the active site in proteases. I. Papain

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2939320

The refined 1.9 A crystal structure of human alpha-thrombin: interaction with D-Phe-Pro-Arg chloromethylketone and significance of the Tyr-Pro-Pro-Trp insertion segment

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2939320

Thrombin is a Na(+)-activated enzyme

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2939320

Murine thrombin lacks Na+ activation but retains high catalytic activity.

21 June 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.113

Crystal structure of anticoagulant thrombin variant E217K provides insights into thrombin allostery

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.113

Mechanism of Na(+) binding to thrombin resolved by ultra-rapid kinetics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.113

An extensive interaction interface between thrombin and factor V is required for factor V activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.113

Roles of low specificity and cofactor interaction sites on thrombin during factor XIII activation. Competition for cofactor sites on thrombin determines its fate.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.113

Molecular dissection of Na+ binding to thrombin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.113

Replacement of thrombin residue G184 with Lys or Arg fails to mimic Na+ binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.113

Thrombin activation of factor XI on activated platelets requires the interaction of factor XI and platelet glycoprotein Ib alpha with thrombin anion-binding exosites I and II, respectively

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.113

Structural requirements for the activation of human factor VIII by thrombin

21 January 2018

1 reference

12 December 2020

Evidence that human alpha-thrombin is a monovalent cation-activated enzyme

1 reference

12 December 2020

Molecular recognition by thrombin. Role of the slow-->fast transition, site-specific ion binding energetics and thermodynamic mapping of structural components

1 reference

12 December 2020

The Na+ Binding Site of Thrombin

1 reference

12 December 2020

Effect of sodium on the energetics of thrombin-thrombomodulin interaction and its relevance for protein C hydrolysis

1 reference

12 December 2020

Rational engineering of activity and specificity in a serine protease

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12 December 2020

Critical role of W60d in thrombin allostery

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12 December 2020

Crystal structure of thrombin in a self-inhibited conformation

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12 December 2020

Rapid kinetics of Na+ binding to thrombin

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12 December 2020

The thrombin mutant W215A/E217A shows safe and potent anticoagulant and antithrombotic effects in vivo

1 reference

12 December 2020

Kinetic pathway for the slow to fast transition of thrombin. Evidence of linked ligand binding at structurally distinct domains

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12 December 2020

Identifiers

DOI

10.1515/BC.2008.113

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26 July 2017

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26 July 2017

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