The alpha-ketoglutarate-dehydrogenase complex: a mediator between mitochondria and oxidative stress in neurodegeneration (Q33987781)

30 July 2017

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title

The alpha-ketoglutarate-dehydrogenase complex: a mediator between mitochondria and oxidative stress in neurodegeneration (English)

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30 July 2017

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3

M Flint Beal

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30 July 2017

Gary E Gibson

1

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30 July 2017

John P Blass

series ordinal

2

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30 July 2017

Victoria Bunik

series ordinal

4

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30 July 2017

language of work or name

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1 January 2005

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30 July 2017

published in

Molecular Neurobiology

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30 July 2017

volume

31

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30 July 2017

issue

1-3

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30 July 2017

page(s)

43-63

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Prediction of cognitive decline in normal elderly subjects with 2-[(18)F]fluoro-2-deoxy-D-glucose/positron-emission tomography (FDG/PET).

30 July 2017

cites work

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12 December 2020

Interplay between mitochondria and cellular calcium signalling

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12 December 2020

Oxidative metabolites of 5-S-cysteinyldopamine inhibit the pyruvate dehydrogenase complex

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12 December 2020

Using lipoate enantiomers and thioredoxin to study the mechanism of the 2‐oxoacid‐dependent dihydrolipoate production by the 2‐oxoacid dehydrogenase complexes

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12 December 2020

Glucose deprivation elicits neurofibrillary tangle-like antigenic changes in hippocampal neurons: prevention by NGF and bFGF

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12 December 2020

Inhibition of PC12 cell redox activity is a specific, early indicator of the mechanism of beta-amyloid-mediated cell death

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12 December 2020

Declines in mitochondrial respiration during cardiac reperfusion: age-dependent inactivation of alpha-ketoglutarate dehydrogenase

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12 December 2020

Alzheimer-type pathology in a patient with mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS).

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12 December 2020

Dietary thiamin level influences levels of its diphosphate form and thiamin-dependent enzymic activities of rat liver

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12 December 2020

Metabolic engineering in Escherichia coli: lowering the lipoyl domain content of the pyruvate dehydrogenase complex adversely affects the growth rate and yield

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12 December 2020

Involvement of Oxidative Stress on the Impairment of Energy Metabolism Induced by Aβ Peptides on PC12 Cells: Protection by Antioxidants

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12 December 2020

Localization of neurofibrillary tangles and beta-amyloid plaques in the brains of living patients with Alzheimer disease

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12 December 2020

Truncated product of the bifunctional DLST gene involved in biogenesis of the respiratory chain

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12 December 2020

Alpha-lipoic acid as a new treatment option for Alzheimer [corrected] type dementia

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12 December 2020

Thiamine therapy in Alzheimer's disease

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12 December 2020

Acrolein inhibits NADH-linked mitochondrial enzyme activity: implications for Alzheimer's disease

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12 December 2020

Oxidative stress increases production of beta-amyloid precursor protein and beta-amyloid (Abeta) in mammalian lenses, and Abeta has toxic effects on lens epithelial cells.

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12 December 2020

Enzymological and physiological consequences of restructuring the lipoyl domain content of the pyruvate dehydrogenase complex of Escherichia coli.

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12 December 2020

Oxidative stress induces intracellular accumulation of amyloid beta-protein (Abeta) in human neuroblastoma cells.

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12 December 2020

Respiratory failure and stimulation of glycolysis in Chinese hamster ovary cells exposed to normobaric hyperoxia

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12 December 2020

Catecholamines enhance dihydrolipoamide dehydrogenase inactivation by the copper Fenton system. Enzyme protection by copper chelators

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12 December 2020

Mitochondrial impairment in the cerebellum of the patients with progressive supranuclear palsy

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12 December 2020

Selective response of various brain cell types during neurodegeneration induced by mild impairment of oxidative metabolism

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12 December 2020

Substantial linkage disequilibrium across the dihydrolipoyl succinyltransferase gene region without Alzheimer's disease association

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12 December 2020

Oxidative alpha-ketoglutarate dehydrogenase inhibition via subtle elevations in monoamine oxidase B levels results in loss of spare respiratory capacity: implications for Parkinson's disease

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12 December 2020

Depolarization of in situ mitochondria due to hydrogen peroxide-induced oxidative stress in nerve terminals: inhibition of alpha-ketoglutarate dehydrogenase

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12 December 2020

Dietary restriction attenuates the neuronal loss, induction of heme oxygenase-1 and blood-brain barrier breakdown induced by impaired oxidative metabolism

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12 December 2020

Neurofibrillary tangles in chronic alcoholics.

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12 December 2020

Inhibition of α‐ketoglutarate dehydrogenase complex promotes cytochrome c release from mitochondria, caspase‐3 activation, and necrotic cell death

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12 December 2020

Regulation of brain mitochondrial H2O2 production by membrane potential and NAD(P)H redox state.

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12 December 2020

Alterations in glucose metabolism induce hypothermia leading to tau hyperphosphorylation through differential inhibition of kinase and phosphatase activities: implications for Alzheimer's disease.

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12 December 2020

Inhibition of bovine kidney alpha-ketoglutarate dehydrogenase complex by reduced nicotinamide adenine dinucleotide in the presence or absence of calcium ion and effect of adenosine 5'-diphosphate on reduced nicotinamide adenine dinucleotide inhibiti

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12 December 2020

The Aβ Peptide of Alzheimer's Disease Directly Produces Hydrogen Peroxide through Metal Ion Reduction†

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12 December 2020

Oxidative stress increases internal calcium stores and reduces a key mitochondrial enzyme

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12 December 2020

Intraneuronal amyloid-beta1-42 production triggered by sustained increase of cytosolic calcium concentration induces neuronal death

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12 December 2020

Inhibition of energy metabolism alters the processing of amyloid precursor protein and induces a potentially amyloidogenic derivative

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12 December 2020

Hg2+-stimulated NADH-oxidase activity of ascaris muscle microsomal lipoamide dehydrogenase

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12 December 2020

Protection by thiols of the mitochondrial complexes from 4-hydroxy-2-nonenal

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12 December 2020

Decline in transcriptional activity of Nrf2 causes age-related loss of glutathione synthesis, which is reversible with lipoic acid

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12 December 2020

β-Amyloid-induced calcium influx induces apoptosis in culture by oxidative stress rather than tau phosphorylation

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12 December 2020

A DLST genotype associated with reduced risk for Alzheimer's disease.

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12 December 2020

Mercury induces cell cytotoxicity and oxidative stress and increases beta-amyloid secretion and tau phosphorylation in SHSY5Y neuroblastoma cells

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12 December 2020

A trial of thiamine in Alzheimer's disease

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12 December 2020

Different mechanisms of oxidative stress and neurotoxicity for Alzheimer's A beta(1--42) and A beta(25--35).

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12 December 2020

Inhibition of select mitochondrial enzymes in PC12 cells exposed to S-(1,1,2,2-tetrafluoroethyl)-L-cysteine

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12 December 2020

Inhibition of acetylcholine synthesis and of carbohydrate utilization by maple-syrup-urine disease metabolites

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12 December 2020

Beta-amyloid inhibits integrated mitochondrial respiration and key enzyme activities

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12 December 2020

Induction of Alzheimer antigens by an uncoupler of oxidative phosphorylation

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12 December 2020

Enhanced brain levels of 8,12-iso-iPF2alpha-VI differentiate AD from frontotemporal dementia

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12 December 2020

Proteomics analysis of rat brain postsynaptic density. Implications of the diverse protein functional groups for the integration of synaptic physiology

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12 December 2020

Structural and functional peculiarities of alpha-ketoglutarate dehydrogenase with non-interacting active sites

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12 December 2020

Effect of DL-alpha-lipoic acid on mitochondrial enzymes in aged rats

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12 December 2020

Metabolic enzymes of mycobacteria linked to antioxidant defense by a thioredoxin-like protein

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12 December 2020

Hydrogen peroxide mediates amyloid beta protein toxicity

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12 December 2020

Age and ApoE genotype interaction in Alzheimer's disease: an FDG-PET study

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12 December 2020

Impaired cerebral glucose metabolism and cognitive functioning predict deterioration in mild cognitive impairment

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12 December 2020

Metabolic impairment elicits brain cell type-selective changes in oxidative stress and cell death in culture.

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12 December 2020

Inhibition of the alpha-ketoglutarate dehydrogenase complex alters mitochondrial function and cellular calcium regulation

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12 December 2020

Inhibition of NADH-linked mitochondrial respiration by 4-hydroxy-2-nonenal

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12 December 2020

Alpha-ketoglutarate dehydrogenase in Alzheimer brains bearing the APP670/671 mutation

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12 December 2020

The isomers of thioctic acid alter C-deoxyglucose incorporation in rat basal ganglia

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12 December 2020

Frontal lobe dysfunction in progressive supranuclear palsy: evidence for oxidative stress and mitochondrial impairment

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12 December 2020

Inactivation of 2-oxoglutarate dehydrogenase in rat liver mitochondria by its substrate and t-butyl hydroperoxide

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12 December 2020

Hippocampal formation glucose metabolism and volume losses in MCI and AD.

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12 December 2020

No association between DLST gene and Alzheimer's disease or Wernicke-Korsakoff syndrome

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12 December 2020

Immunochemical characterization of the deficiency of the alpha-ketoglutarate dehydrogenase complex in thiamine-deficient rat brain.

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12 December 2020

ABAD directly links Abeta to mitochondrial toxicity in Alzheimer's disease

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12 December 2020

Modulation by DLST of the genetic risk of Alzheimer's disease in a very elderly population

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12 December 2020

Increase of brain oxidative stress in mild cognitive impairment: a possible predictor of Alzheimer disease

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12 December 2020

Ca2(+)-binding to citrate cycle dehydrogenases

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12 December 2020

N-acetyl-L-cysteine protects SHSY5Y neuroblastoma cells from oxidative stress and cell cytotoxicity: effects on beta-amyloid secretion and tau phosphorylation

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12 December 2020

Longitudinal PET Evaluation of Cerebral Metabolic Decline in Dementia: A Potential Outcome Measure in Alzheimer's Disease Treatment Studies

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12 December 2020

Brain metabolic decreases related to the dose of the ApoE e4 allele in Alzheimer's disease

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12 December 2020

Association of the dihydrolipoamide dehydrogenase gene with Alzheimer's disease in an Ashkenazi Jewish population

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12 December 2020

Functional brain abnormalities in young adults at genetic risk for late-onset Alzheimer's dementia

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12 December 2020

Protein-bound acrolein: a novel marker of oxidative stress in Alzheimer's disease.

1 reference

12 December 2020

The alpha-ketoglutarate dehydrogenase complex

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12 December 2020

Isoquinoline derivatives as endogenous neurotoxins in the aetiology of Parkinson's disease

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12 December 2020

Inactivation of mitochondrial metabolism by hyperoxia-induced oxidative stress

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12 December 2020

Structure-function analysis of recombinant substrate protein 22 kDa (SP-22). A mitochondrial 2-CYS peroxiredoxin organized as a decameric toroid

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12 December 2020

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12 December 2020

Senile plaque composition and posttranslational modification of amyloid-beta peptide and associated proteins

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12 December 2020

Reversible inactivation of alpha-ketoglutarate dehydrogenase in response to alterations in the mitochondrial glutathione status

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12 December 2020

Activation of mitochondrial 2-oxoacid dehydrogenases by thioredoxin.

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12 December 2020

Change in alpha-ketoglutarate dehydrogenase cooperative properties due to dihydrolipoate and NADH

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12 December 2020

Transglutaminase-catalyzed inactivation of glyceraldehyde 3-phosphate dehydrogenase and alpha-ketoglutarate dehydrogenase complex by polyglutamine domains of pathological length

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12 December 2020

Deficits in a tricarboxylic acid cycle enzyme in brains from patients with Parkinson's disease

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12 December 2020

The alpha-ketoglutarate dehydrogenase complex in neurodegeneration

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12 December 2020

Inhibition of Krebs cycle enzymes by hydrogen peroxide: A key role of [alpha]-ketoglutarate dehydrogenase in limiting NADH production under oxidative stress.

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12 December 2020

Dichloroacetate exerts therapeutic effects in transgenic mouse models of Huntington's disease

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12 December 2020

Review: Alzheimer's amyloid beta-peptide-associated free radical oxidative stress and neurotoxicity

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12 December 2020

Oxidative stress promotes specific protein damage in Saccharomyces cerevisiae

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12 December 2020

Differential alterations in antioxidant capacity in cells from Alzheimer patients

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12 December 2020

Brain protein and alpha-ketoglutarate dehydrogenase complex activity in Alzheimer's disease.

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12 December 2020

Mice deficient in dihydrolipoamide dehydrogenase show increased vulnerability to MPTP, malonate and 3-nitropropionic acid neurotoxicity

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12 December 2020

Increased lipid peroxidation precedes amyloid plaque formation in an animal model of Alzheimer amyloidosis.

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12 December 2020

Abnormalities of mitochondrial enzymes in Alzheimer disease

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12 December 2020

Endogenous mitochondrial oxidative stress: neurodegeneration, proteomic analysis, specific respiratory chain defects, and efficacious antioxidant therapy in superoxide dismutase 2 null mice

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12 December 2020

Specific phosphorylation of Torpedo 43K rapsyn by endogenous kinase(s) with thiamine triphosphate as the phosphate donor

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12 December 2020

Novel neuritic clusters with accumulations of amyloid precursor protein and amyloid precursor-like protein 2 immunoreactivity in brain regions damaged by thiamine deficiency.

1 reference

12 December 2020

Frontotemporal dementia: clinical, neuroimaging, and molecular biological findings in 6 patients.

1 reference

12 December 2020

Inhibition of the alpha-ketoglutarate dehydrogenase and pyruvate dehydrogenase complexes by a putative aberrant metabolite of serotonin, tryptamine-4,5-dione

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12 December 2020

Association between DLST gene polymorphism and Alzheimer's disease

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12 December 2020

2-Oxo acid dehydrogenase complexes in redox regulation

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12 December 2020

Inhibition of α-Ketoglutarate dehydrogenase by isoquinoline derivatives structurally related to 1 -methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)

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12 December 2020

The effects of calcium ions and adenine nucleotides on the activity of pig heart 2-oxoglutarate dehydrogenase complex

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12 December 2020

Metabolic impairment induces oxidative stress, compromises inflammatory responses, and inactivates a key mitochondrial enzyme in microglia

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12 December 2020

Alterations in cerebral blood flow and glucose utilization in mice overexpressing the amyloid precursor protein

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12 December 2020

Inherent abnormalities in energy metabolism in Alzheimer disease. Interaction with cerebrovascular compromise

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12 December 2020

The effects of perturbed energy metabolism on the processing of amyloid precursor protein in PC12 cells

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12 December 2020

Glucose and memory in mild senile dementia of the Alzheimer type

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12 December 2020

Thiamine-dependent enzyme changes in the brains of alcoholics: relationship to the Wernicke-Korsakoff syndrome

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12 December 2020

Zinc is a potent inhibitor of thiol oxidoreductase activity and stimulates reactive oxygen species production by lipoamide dehydrogenase.

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12 December 2020

Apoptotic neuronal cell death induced by the non-fibrillar amyloid-beta peptide proceeds through an early reactive oxygen species-dependent cytoskeleton perturbation

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12 December 2020

Reduction of nitrofuran compounds by heart lipoamide dehydrogenase: role of flavin and the reactive disulfide groups

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12 December 2020

Inactivation of the 2-oxo acid dehydrogenase complexes upon generation of intrinsic radical species

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12 December 2020

Global organization of metabolic fluxes in the bacterium Escherichia coli

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12 December 2020

Isofurans, but not F2-isoprostanes, are increased in the substantia nigra of patients with Parkinson's disease and with dementia with Lewy body disease

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12 December 2020

Mitochondrial damage in Alzheimer's disease varies with apolipoprotein E genotype.

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12 December 2020

Vascular factors are critical in selective neuronal loss in an animal model of impaired oxidative metabolism.

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12 December 2020

Antioxidant neuroprotection in Alzheimer's disease as preventive and therapeutic approach

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12 December 2020

Identifiers

DOI

10.1385/MN:31:1-3:043

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Dimensions Publication ID

30 July 2017

1039732098

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