Genome-wide association studies in cardiac electrophysiology: recent discoveries and implications for clinical practice (Q34020748)

30 July 2017

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title

Genome-wide association studies in cardiac electrophysiology: recent discoveries and implications for clinical practice (English)

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genome-wide association study

30 July 2017

main subject

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4

Patrick T Ellinor

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30 July 2017

2

Steven A Lubitz

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30 July 2017

3

Stefan Kääb

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30 July 2017

David J Milan

1

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30 July 2017

publication date

25 April 2010

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30 July 2017

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30 July 2017

volume

7

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30 July 2017

issue

8

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30 July 2017

page(s)

1141-1148

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Common variants in KCNN3 are associated with lone atrial fibrillation

30 July 2017

cites work

1 reference

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5 July 2018

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Variation in the 4q25 chromosomal locus predicts atrial fibrillation after coronary artery bypass graft surgery

5 July 2018

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5 July 2018

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Atrial fibrillation and ethnicity: the known, the unknown and the paradox

5 July 2018

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NOS1AP is a genetic modifier of the long-QT syndrome

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2910183

Genetic variation in GPR133 is associated with height: genome wide association study in the self-contained population of Sorbs

5 July 2018

1 reference

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Variants in ZFHX3 are associated with atrial fibrillation in individuals of European ancestry

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2910183

A sequence variant in ZFHX3 on 16q22 associates with atrial fibrillation and ischemic stroke

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2910183

Common genetic variation near the phospholamban gene is associated with cardiac repolarisation: meta-analysis of three genome-wide association studies

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2910183

Long-term outcomes in individuals with prolonged PR interval or first-degree atrioventricular block

5 July 2018

1 reference

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Sodium channel mutations and arrhythmias

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2910183

Common variants at ten loci modulate the QT interval duration in the QTSCD Study

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2910183

Common variants at ten loci influence QT interval duration in the QTGEN Study

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2910183

Development of a risk score for atrial fibrillation (Framingham Heart Study): a community-based cohort study

5 July 2018

1 reference

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Genetic variations in nitric oxide synthase 1 adaptor protein are associated with sudden cardiac death in US white community-based populations

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2910183

Prevention of atrial fibrillation: report from a national heart, lung, and blood institute workshop

5 July 2018

1 reference

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Large scale replication and meta-analysis of variants on chromosome 4q25 associated with atrial fibrillation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2910183

A genome-wide association study identifies novel and functionally related susceptibility Loci for Kawasaki disease

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2910183

Genetic mapping in human disease

5 July 2018

1 reference

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Pitx2c and Nkx2-5 are required for the formation and identity of the pulmonary myocardium

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2910183

Variants conferring risk of atrial fibrillation on chromosome 4q25.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2910183

A common genetic variant in the NOS1 regulator NOS1AP modulates cardiac repolarization

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2910183

Caveolae and caveolins in the cardiovascular system

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2910183

Altered Expression of Small-Conductance Ca2+-Activated K+ (SK3) Channels Modulates Arterial Tone and Blood Pressure

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2910183

Caveolin-1 null mice develop cardiac hypertrophy with hyperactivation of p42/44 MAP kinase in cardiac fibroblasts

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2910183

Variant of SCN5A sodium channel implicated in risk of cardiac arrhythmia

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2910183

Defects in caveolin-1 cause dilated cardiomyopathy and pulmonary hypertension in knockout mice

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2910183

The transcription factor Pitx2 mediates situs-specific morphogenesis in response to left-right asymmetric signals

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2910183

Mutations in the hminK gene cause long QT syndrome and suppress IKs function

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2910183

Positional cloning of a novel potassium channel gene: KVLQT1 mutations cause cardiac arrhythmias

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2910183

A mechanistic link between an inherited and an acquired cardiac arrhythmia: HERG encodes the IKr potassium channel

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2910183

A large-scale genome-wide association study of Asian populations uncovers genetic factors influencing eight quantitative traits

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2910183

Genetic deficit of SK3 and IK1 channels disrupts the endothelium-derived hyperpolarizing factor vasodilator pathway and causes hypertension

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2910183

Prolonged QTc interval and risk of sudden cardiac death in a population of older adults

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2910183

Molecular basis of the long-QT syndrome associated with deafness

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2910183

Several common variants modulate heart rate, PR interval and QRS duration

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2910183

QTc prolongation measured by standard 12-lead electrocardiography is an independent risk factor for sudden death due to cardiac arrest

29 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20423731

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

QT interval prolongation predicts cardiovascular mortality in an apparently healthy population

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20423731

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

1 reference

https://pubmed.ncbi.nlm.nih.gov/20423731

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.HRTHM.2010.04.021

1 reference

30 July 2017

1 reference

30 July 2017

1 reference