Covalent disulfide-linked anti-CEA diabody allows site-specific conjugation and radiolabeling for tumor targeting applications (Q34134440)

31 July 2017

title

Covalent disulfide-linked anti-CEA diabody allows site-specific conjugation and radiolabeling for tumor targeting applications (English)

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31 July 2017

Tove Olafsen

1

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31 July 2017

Chia-Wei Cheung

2

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31 July 2017

Paul J Yazaki

3

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31 July 2017

Lin Li

4

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31 July 2017

Gobalakrishnan Sundaresan

5

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31 July 2017

Sanjiv S Gambhir

6

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31 July 2017

Mark A Sherman

7

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31 July 2017

Lawrence E Williams

8

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31 July 2017

John E Shively

9

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31 July 2017

Andrew A Raubitschek

10

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31 July 2017

Anna M Wu

11

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31 July 2017

publication date

1 January 2004

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Protein Engineering Design and Selection

31 July 2017

published in

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31 July 2017

volume

17

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31 July 2017

issue

1

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31 July 2017

page(s)

21-27

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AMIDE: a free software tool for multimodality medical image analysis

31 July 2017

cites work

1 reference

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The crystal structure of an anti-CEA scFv diabody assembled from T84.66 scFvs in V(L)-to-V(H) orientation: implications for diabody flexibility

5 July 2018

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Tumor targeting of radiometal labeled anti-CEA recombinant T84.66 diabody and t84.66 minibody: comparison to radioiodinated fragments

5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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Preparation and characterization of a disulfide-stabilized Fv fragment of the anti-Tac antibody: comparison with its single-chain analog

5 July 2018

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Impact of the high tyrosine fraction in complementarity determining regions: measured and predicted effects of radioiodination on IgG immunoreactivity

5 July 2018

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Targeting of liver metastases of colorectal cancer with IgG, F(ab')2, and Fab' anti-carcinoembryonic antigen antibodies labeled with 99mTc: the role of metabolism and kinetics

5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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Secretion of immunoglobulin M assembly intermediates in the presence of reducing agents

5 July 2018

1 reference

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A comparison of strategies to stabilize immunoglobulin Fv-fragments

5 July 2018

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5 July 2018

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Domain motions in phosphoglycerate kinase: determination of interdomain distance distributions by site-specific labeling and time-resolved fluorescence energy transfer

5 July 2018

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5 July 2018

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Immunoscintigraphic detection of the ED-B domain of fibronectin, a marker of angiogenesis, in patients with cancer

5 July 2018

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Reduction of kidney uptake in radiometal labeled peptide linkers conjugated to recombinant antibody fragments. Site-specific conjugation of DOTA-peptides to a Cys-diabody

28 October 2018

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Mammalian expression and hollow fiber bioreactor production of recombinant anti-CEA diabody and minibody for clinical applications

28 October 2018

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High-resolution 3D Bayesian image reconstruction using the microPET small-animal scanner

28 October 2018

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28 October 2018

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Mutations of two lysine residues in the CDR loops of a recombinant immunotoxin that reduce its sensitivity to chemical derivatization.

28 October 2018

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IgM secretory tailpiece drives multimerisation of bivalent scFv fragments in eukaryotic cells

28 October 2018

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12 December 2020

Abundant tyrosine residues in the antigen binding site in anti-osteosarcoma monoclonal antibodies TP-1 and TP-3: Application to radiolabeling

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12 December 2020

Efficient production of high specific activity 64Cu using a biomedical cyclotron

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12 December 2020

Chemical design of radiolabeled antibody fragments for low renal radioactivity levels

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12 December 2020

Technetium-99m radiolabeling using a phage-derived single-chain Fv with a C-terminal cysteine

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12 December 2020

Highly specific in vivo tumor targeting by monovalent and divalent forms of 741F8 anti-c-erbB-2 single-chain Fv

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12 December 2020

Effects of unpaired cysteines on yield, solubility and activity of different recombinant antibody constructs expressed in E. coli

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12 December 2020

Site-specific conjugation on serine right-arrow cysteine variant monoclonal antibodies

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12 December 2020

Stable one-step technetium-99m labeling of His-tagged recombinant proteins with a novel Tc(I)-carbonyl complex

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12 December 2020

Improved tumour targeting by disulphide stabilized diabodies expressed in Pichia pastoris

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12 December 2020

Site-specific conjugation to interleukin 4 containing mutated cysteine residues produces interleukin 4-toxin conjugates with improved binding and activity

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12 December 2020

Identifiers

DOI

10.1093/PROTEIN/GZH009

1 reference

31 July 2017

1 reference

31 July 2017

1 reference