Tim-3 negatively regulates cytotoxicity in exhausted CD8+ T cells in HIV infection (Q34335966)

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7 February 2020

title

Tim-3 negatively regulates cytotoxicity in exhausted CD8+ T cells in HIV infection (English)

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7 February 2020

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2

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7 February 2020

Sonya A MacParland

5

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7 February 2020

Jennifer L Gommerman

12

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Colin Kovacs

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7 February 2020

4

Feng Yun Yue

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7 February 2020

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Mario A Ostrowski

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7 February 2020

6

Kiera Clayton

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7 February 2020

author name string

Ali Sakhdari

1

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7 February 2020

Bahareh Vali

3

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7 February 2020

Richard Bradley Jones

7

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7 February 2020

Jun Liu

8

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7 February 2020

Erika Yue Lee

9

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7 February 2020

Erika Benko

10

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7 February 2020

Rupert Kaul

13

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language of work or name

English

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publication date

5 July 2012

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7 February 2020

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7 February 2020

volume

7

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7 February 2020

issue

7

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7 February 2020

page(s)

e40146

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Creative Commons Attribution 4.0 International

7 February 2020

copyright license

start time

5 July 2012

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

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Negative immune regulator Tim-3 is overexpressed on T cells in hepatitis C virus infection and its blockade rescues dysfunctional CD4+ and CD8+ T cells

6 July 2018

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Rapid up-regulation and granule-independent transport of perforin to the immunological synapse define a novel mechanism of antigen-specific CD8+ T cell cytotoxic activity.

6 July 2018

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Blockade of Tim-3 pathway ameliorates interferon-gamma production from hepatic CD8+ T cells in a mouse model of hepatitis B virus infection

6 July 2018

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Lytic granule loading of CD8+ T cells is required for HIV-infected cell elimination associated with immune control

6 July 2018

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Tim-3 expression defines a novel population of dysfunctional T cells with highly elevated frequencies in progressive HIV-1 infection

6 July 2018

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Promotion of tissue inflammation by the immune receptor Tim-3 expressed on innate immune cells

6 July 2018

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HIV controllers exhibit potent CD8 T cell capacity to suppress HIV infection ex vivo and peculiar cytotoxic T lymphocyte activation phenotype

6 July 2018

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PD-1 up-regulation is correlated with HIV-specific memory CD8+ T-cell exhaustion in typical progressors but not in long-term nonprogressors

6 July 2018

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Presence of distinct subsets of cytolytic CD8+ T cells in chronic HIV infection.

6 July 2018

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Proliferative capacity of epitope-specific CD8 T-cell responses is inversely related to viral load in chronic human immunodeficiency virus type 1 infection

6 July 2018

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PD-1 is a regulator of virus-specific CD8+ T cell survival in HIV infection

6 July 2018

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6 July 2018

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PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression

6 July 2018

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Upregulation of PD-1 expression on HIV-specific CD8+ T cells leads to reversible immune dysfunction

6 July 2018

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HIV nonprogressors preferentially maintain highly functional HIV-specific CD8+ T cells

6 July 2018

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Differential transcription of Eomes and T-bet during maturation of mouse uterine natural killer cells

6 July 2018

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6 July 2018

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HIV-1 viremia prevents the establishment of interleukin 2-producing HIV-specific memory CD4+ T cells endowed with proliferative capacity

6 July 2018

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Suppression of HIV-1 replication by HIV-1-irrelevant CD8+ cytotoxic T lymphocytes resulting in preservation of persistently HIV-1-infected cells in vitro

6 July 2018

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Interaction of Tim-3 and Tim-3 ligand regulates T helper type 1 responses and induction of peripheral tolerance

6 July 2018

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Tim-3 inhibits T helper type 1-mediated auto- and alloimmune responses and promotes immunological tolerance.

6 July 2018

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Perforin and the granule exocytosis cytotoxicity pathway

6 July 2018

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Viral persistence alters CD8 T-cell immunodominance and tissue distribution and results in distinct stages of functional impairment

6 July 2018

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Expression of CD57 defines replicative senescence and antigen-induced apoptotic death of CD8+ T cells

6 July 2018

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6 July 2018

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Functional heterogeneity of cytokines and cytolytic effector molecules in human CD8+ T lymphocytes

6 July 2018

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Suppression of HIV replication in the resting CD4+ T cell reservoir by autologous CD8+ T cells: implications for the development of therapeutic strategies

6 July 2018

1 reference

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Impaired function of circulating HIV-specific CD8(+) T cells in chronic human immunodeficiency virus infection.

6 July 2018

1 reference

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Perforin-mediated cytotoxicity is critical for surveillance of spontaneous lymphoma

6 July 2018

1 reference

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HIV-specific CD8(+) T cells produce antiviral cytokines but are impaired in cytolytic function

6 July 2018

1 reference

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Perforin and Fas/Fas ligand-mediated cytotoxicity in acute and chronic woodchuck viral hepatitis

6 July 2018

1 reference

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CD28 costimulation increases CD8+ cell suppression of HIV replication

6 July 2018

1 reference

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Suppression of HIV replication by lymphoid tissue CD8+ cells correlates with the clinical state of HIV-infected individuals

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3390352

Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3390352

Major expansion of CD8+ T cells with a predominant V beta usage during the primary immune response to HIV.

6 July 2018

1 reference

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CD8+ T cell-mediated protection against an intracellular bacterium by perforin-dependent cytotoxicity.

6 July 2018

1 reference

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Perforin and granzymes: crucial effector molecules in cytolytic T lymphocyte and natural killer cell-mediated cytotoxicity.

6 July 2018

1 reference

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Inhibition of Cytotoxicity and Cytokine Release of CD8+ HIV-Specific Cytotoxic T Lymphocytes by Pentoxifylline

6 July 2018

1 reference

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Fas and perforin pathways as major mechanisms of T cell-mediated cytotoxicity

6 July 2018

1 reference

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Perforin-dependent and -independent pathways of cytotoxicity mediated by lymphocytes

6 July 2018

1 reference

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A noncytotoxic mast cell tumor line exhibits potent IgE-dependent cytotoxicity after transfection with the cytolysin/perforin gene

6 July 2018

1 reference

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CD8+ cell anti-HIV activity: nonlytic suppression of virus replication

6 July 2018

1 reference

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Abundant expression of granzyme A, but not perforin, in granules of CD8+ T cells in GALT: implications for immune control of HIV-1 infection

6 July 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0040146

HIV-1-specific CD4+ T cells are detectable in most individuals with active HIV-1 infection, but decline with prolonged viral suppression

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0040146

Characterisation of diverse PRF1 mutations leading to decreased natural killer cell activity in North American families with haemophagocytic lymphohistiocytosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0040146

Induction of cytotoxic granules in human memory CD8+ T cell subsets requires cell cycle progression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0040146

Detailed immunophenotype of CD8+ memory cytotoxic T-lymphocytes (CTL) against HIV-1 with respect to expression of CD45RA/RO, CD62L and CD28 antigens

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0040146

The fraction of perforin-expressing HIV-specific CD8 T cells is a marker for disease progression in HIV infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0040146

Antigen-independent induction of Tim-3 expression on human T cells by the common γ-chain cytokines IL-2, IL-7, IL-15, and IL-21 is associated with proliferation and is dependent on the phosphoinositide 3-kinase pathway

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3390352

Circulating CD8 T lymphocytes in human immunodeficiency virus-infected individuals have impaired function and downmodulate CD3 zeta, the signaling chain of the T-cell receptor complex.

27 October 2018

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Immune activation set point during early HIV infection predicts subsequent CD4+ T-cell changes independent of viral load

27 October 2018

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Most antiviral CD8 T cells during chronic viral infection do not express high levels of perforin and are not directly cytotoxic

21 January 2018

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0040146

Cytolytic T-cell cytotoxicity is mediated through perforin and Fas lytic pathways

21 January 2018

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Flow cytometric detection of perforin upregulation in human CD8 T cells

21 January 2018

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12 December 2020

HIV-1 specific CD8+ T cells with an effector phenotype and control of viral replication

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12 December 2020

Cytotoxicity with target DNA breakdown by rat basophilic leukemia cells expressing both cytolysin and granzyme A

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12 December 2020

Activation of CD8-dependent cytotoxic T lymphocyte adhesion and degranulation by peptide class I antigen complexes

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12 December 2020

CD8+ T-cell-mediated suppression of HIV replication in the first year of life: association with lower viral load and favorable early survival

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12 December 2020

Suppression of HIV replication in vitro by CD8+ T-cells from HIV-infected and HIV-seronegative individuals

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12 December 2020

Perforin is not co-expressed with granzyme A within cytotoxic granules in CD8 T lymphocytes present in lymphoid tissue during chronic HIV infection

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12 December 2020

Sensitive and viable identification of antigen-specific CD8+ T cells by a flow cytometric assay for degranulation

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12 December 2020

CD8(+) tumor-infiltrating T cells are deficient in perforin-mediated cytolytic activity due to defective microtubule-organizing center mobilization and lytic granule exocytosis

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HIV-specific CD8+ T cell proliferation is coupled to perforin expression and is maintained in nonprogressors

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12 December 2020

10.1371/JOURNAL.PONE.0040146

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22792231%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

0 references

1 reference

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7 February 2020

PubMed publication ID

22792231

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22792231%20AND%20SRC:MED&resulttype=core&format=json