Antitumor activity of emodin against pancreatic cancer depends on its dual role: promotion of apoptosis and suppression of angiogenesis (Q34372558)

1 August 2017

title

Antitumor activity of emodin against pancreatic cancer depends on its dual role: promotion of apoptosis and suppression of angiogenesis (English)

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1 August 2017

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10

Dian-Lei Liu

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1 August 2017

Sheng-Zhang Lin

1

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1 August 2017

Wei-Tian Wei

2

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1 August 2017

Hui Chen

3

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1 August 2017

Kang-Jie Chen

4

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1 August 2017

Hong-Fei Tong

5

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1 August 2017

Zhao-Hong Wang

6

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1 August 2017

Zhong-Lin Ni

7

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1 August 2017

Hai-Bin Liu

8

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1 August 2017

Hong-Chun Guo

9

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1 August 2017

language of work or name

English

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publication date

2 August 2012

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1 August 2017

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1 August 2017

volume

7

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1 August 2017

issue

8

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1 August 2017

page(s)

e42146

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Creative Commons Attribution 4.0 International

1 August 2017

copyright license

start time

2 August 2012

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April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

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Enhanced antitumor efficacy by the combination of emodin and gemcitabine against human pancreatic cancer cells via downregulation of the expression of XIAP in vitro and in vivo

6 July 2018

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Nimbolide retards tumor cell migration, invasion, and angiogenesis by downregulating MMP-2/9 expression via inhibiting ERK1/2 and reducing DNA-binding activity of NF-κB in colon cancer cells

6 July 2018

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Antiproliferative and antimetastatic effects of emodin on human pancreatic cancer

6 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3410916

Emodin potentiates the antitumor effects of gemcitabine in pancreatic cancer cells via inhibition of nuclear factor-κB.

6 July 2018

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Qingyihuaji formula inhibits progress of liver metastases from advanced pancreatic cancer xenograft by targeting to decrease expression of Cyr61 and VEGF.

6 July 2018

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Zebrafish bioassay-guided natural product discovery: isolation of angiogenesis inhibitors from East African medicinal plants

6 July 2018

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Enhanced effect of gemcitabine by emodin against pancreatic cancer in vivo via cytochrome C-regulated apoptosis

6 July 2018

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Leptin upregulates VEGF in breast cancer via canonic and non-canonical signalling pathways and NFkappaB/HIF-1alpha activation

6 July 2018

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A short-hairpin RNA targeting osteopontin downregulates MMP-2 and MMP-9 expressions in prostate cancer PC-3 cells

6 July 2018

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Involvement of matrix metalloproteinases on the inhibition of cells invasion and migration by emodin in human neuroblastoma SH-SY5Y cells

6 July 2018

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Curcumin potentiates antitumor activity of gemcitabine in an orthotopic model of pancreatic cancer through suppression of proliferation, angiogenesis, and inhibition of nuclear factor-kappaB-regulated gene products.

6 July 2018

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Randomized phase III study of exatecan and gemcitabine compared with gemcitabine alone in untreated advanced pancreatic cancer

6 July 2018

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Emodin inhibits vascular endothelial growth factor-A-induced angiogenesis by blocking receptor-2 (KDR/Flk-1) phosphorylation

6 July 2018

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Molecular evidence for increased antitumor activity of gemcitabine by genistein in vitro and in vivo using an orthotopic model of pancreatic cancer

6 July 2018

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Gemcitabine in combination with oxaliplatin compared with gemcitabine alone in locally advanced or metastatic pancreatic cancer: results of a GERCOR and GISCAD phase III trial.

6 July 2018

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Recent developments in the regulation of the angiogenic switch by cellular stress factors in tumors

6 July 2018

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Nuclear factor-kappaB: the enemy within

6 July 2018

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Therapeutic potential of selective cyclooxygenase-2 inhibitors in the management of tumor angiogenesis

6 July 2018

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Clinical applications of angiogenic growth factors and their inhibitors

6 July 2018

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Nitric oxide production contributes to the angiogenic properties of vascular endothelial growth factor in human endothelial cells

6 July 2018

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The role of eNOS, iNOS, and NF-kappaB in upregulation and activation of cyclooxygenase-2 and infarct size reduction by atorvastatin

6 July 2018

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The effect of emodin on VEGF receptors in human colon cancer cells

27 October 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3410916

Endothelial progenitor cell proliferation and differentiation is regulated by erythropoietin Rapid Communication

27 October 2018

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12 December 2020

Effects of rapamycin on number activity and eNOS of endothelial progenitor cells from peripheral blood

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12 December 2020

Anthraquinone derivative emodin inhibits tumor-associated angiogenesis through inhibition of extracellular signal-regulated kinase 1/2 phosphorylation

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12 December 2020

Chemotherapeutic stress selectively activates NF-kappa B-dependent AKT and VEGF expression in liver cancer-derived endothelial cells

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12 December 2020

10.1371/JOURNAL.PONE.0042146

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DOI

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1 August 2017

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1 August 2017

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