Tissue-specific actions of the metabolic hormones FGF15/19 and FGF21. (Q34778879)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25476453%20AND%20SRC:MED&resulttype=core&format=json

24 February 2020

review article

1 reference

title

Tissue-specific actions of the metabolic hormones FGF15/19 and FGF21 (English)

1 reference

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24 February 2020

1

1 reference

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24 February 2020

David Mangelsdorf

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25476453%20AND%20SRC:MED&resulttype=core&format=json

24 February 2020

author name string

Steven A Kliewer

series ordinal

3

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24 February 2020

publication date

1 December 2014

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25476453%20AND%20SRC:MED&resulttype=core&format=json

Trends in Endocrinology and Metabolism

24 February 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25476453%20AND%20SRC:MED&resulttype=core&format=json

24 February 2020

volume

26

1 reference

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24 February 2020

issue

1

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24 February 2020

page(s)

22-29

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FGF21 is an endocrine signal of protein restriction

24 February 2020

cites work

1 reference

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FGF21 acts centrally to induce sympathetic nerve activity, energy expenditure, and weight loss.

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Circulating FGF21 is liver derived and enhances glucose uptake during refeeding and overfeeding.

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The breadth of FGF21's metabolic actions are governed by FGFR1 in adipose tissue

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FGF21 regulates metabolism and circadian behavior by acting on the nervous system

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7 July 2018

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7 July 2018

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Fibroblast growth factor-19 action in the brain reduces food intake and body weight and improves glucose tolerance in male rats.

7 July 2018

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The starvation hormone, fibroblast growth factor-21, extends lifespan in mice.

7 July 2018

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βKlotho is required for fibroblast growth factor 21 effects on growth and metabolism

7 July 2018

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FGF21 promotes metabolic homeostasis via white adipose and leptin in mice

7 July 2018

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Targeting FGFR4 inhibits hepatocellular carcinoma in preclinical mouse models

7 July 2018

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Differential specificity of endocrine FGF19 and FGF21 to FGFR1 and FGFR4 in complex with KLB.

7 July 2018

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7 July 2018

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Fibroblast growth factor 21 promotes bone loss by potentiating the effects of peroxisome proliferator-activated receptor γ.

7 July 2018

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Fibroblast growth factor-21 regulates PPARγ activity and the antidiabetic actions of thiazolidinediones.

7 July 2018

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FGF21 regulates PGC-1α and browning of white adipose tissues in adaptive thermogenesis

7 July 2018

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Endocrine fibroblast growth factors 15/19 and 21: from feast to famine

7 July 2018

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Activating transcription factor 4-dependent induction of FGF21 during amino acid deprivation.

7 July 2018

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Amelioration of type 2 diabetes by antibody-mediated activation of fibroblast growth factor receptor 1.

7 July 2018

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Fibroblast growth factor 21 (FGF21) in human cerebrospinal fluid: relationship with plasma FGF21 and body adiposity

7 July 2018

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Integrated regulation of hepatic metabolism by fibroblast growth factor 21 (FGF21) in vivo

7 July 2018

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The transcription factor cyclic AMP-responsive element-binding protein H regulates triglyceride metabolism

7 July 2018

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FGF15/19 regulates hepatic glucose metabolism by inhibiting the CREB-PGC-1α pathway

7 July 2018

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FGF19 regulates cell proliferation, glucose and bile acid metabolism via FGFR4-dependent and independent pathways

7 July 2018

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7 July 2018

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7 July 2018

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Brown adipose tissue responds to cold and adrenergic stimulation by induction of FGF21.

7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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Increased fibroblast growth factor 21 in obesity and nonalcoholic fatty liver disease

7 July 2018

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Fibroblast growth factor 21 action in the brain increases energy expenditure and insulin sensitivity in obese rats

7 July 2018

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Hepatic FGF21 expression is induced at birth via PPARalpha in response to milk intake and contributes to thermogenic activation of neonatal brown fat.

7 July 2018

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Vasopressin and the output of the hypothalamic biological clock.

7 July 2018

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FGF19-induced hepatocyte proliferation is mediated through FGFR4 activation

7 July 2018

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Fibroblast growth factor 21-deficient mice demonstrate impaired adaptation to ketosis

7 July 2018

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7 July 2018

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FGF21 induces PGC-1alpha and regulates carbohydrate and fatty acid metabolism during the adaptive starvation response

7 July 2018

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Fibroblast growth factor 21 controls glycemia via regulation of hepatic glucose flux and insulin sensitivity

7 July 2018

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7 July 2018

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FGF15/FGFR4 integrates growth factor signaling with hepatic bile acid metabolism and insulin action

7 July 2018

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7 July 2018

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Bile acids activate fibroblast growth factor 19 signaling in human hepatocytes to inhibit cholesterol 7alpha-hydroxylase gene expression

7 July 2018

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7 July 2018

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7 July 2018

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Adipose fibroblast growth factor 21 is up-regulated by peroxisome proliferator-activated receptor gamma and altered metabolic states.

7 July 2018

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The fasting polypeptide FGF21 can enter brain from blood

7 July 2018

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Tissue-specific expression of betaKlotho and fibroblast growth factor (FGF) receptor isoforms determines metabolic activity of FGF19 and FGF21

7 July 2018

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PPARalpha is a key regulator of hepatic FGF21.

7 July 2018

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Hepatic fibroblast growth factor 21 is regulated by PPARalpha and is a key mediator of hepatic lipid metabolism in ketotic states

7 July 2018

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Endocrine regulation of the fasting response by PPARalpha-mediated induction of fibroblast growth factor 21

7 July 2018

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Molecular insights into the klotho-dependent, endocrine mode of action of fibroblast growth factor 19 subfamily members

7 July 2018

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The metabolic state of diabetic monkeys is regulated by fibroblast growth factor-21.

7 July 2018

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Fibroblast growth factor-21 improves pancreatic beta-cell function and survival by activation of extracellular signal-regulated kinase 1/2 and Akt signaling pathways.

7 July 2018

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Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis

7 July 2018

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Impaired negative feedback suppression of bile acid synthesis in mice lacking betaKlotho

7 July 2018

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FGF-21 as a novel metabolic regulator

7 July 2018

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Stress and the female reproductive system

7 July 2018

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Fibroblast growth factor 19 increases metabolic rate and reverses dietary and leptin-deficient diabetes.

7 July 2018

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7 July 2018

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Study of Fgf15 gene expression in developing mouse brain

7 July 2018

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Definition of a novel growth factor-dependent signal cascade for the suppression of bile acid biosynthesis

7 July 2018

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A mouse model of hepatocellular carcinoma: ectopic expression of fibroblast growth factor 19 in skeletal muscle of transgenic mice

7 July 2018

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Transgenic mice expressing human fibroblast growth factor-19 display increased metabolic rate and decreased adiposity

7 July 2018

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Structure and expression of a novel human FGF, FGF-19, expressed in the fetal brain

7 July 2018

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Effects of corticotropin-releasing factor on food intake and brown adipose tissue thermogenesis in rats

7 July 2018

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FGF21 maintains glucose homeostasis by mediating the cross talk between liver and brain during prolonged fasting

7 July 2018

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Fibroblast growth factor 19 entry into brain

26 October 2018

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The effects of LY2405319, an FGF21 analog, in obese human subjects with type 2 diabetes

26 October 2018

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Adiponectin mediates the metabolic effects of FGF21 on glucose homeostasis and insulin sensitivity in mice

26 October 2018

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Treating diabetes and obesity with an FGF21-mimetic antibody activating the βKlotho/FGFR1c receptor complex.

26 October 2018

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Long-acting FGF21 has enhanced efficacy in diet-induced obese mice and in obese rhesus monkeys

26 October 2018

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Liver fat but not other adiposity measures influence circulating FGF21 levels in healthy young adult twins.

26 October 2018

1 reference

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Mitochondrial myopathy induces a starvation-like response

26 October 2018

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Serum concentrations and tissue expression of a novel endocrine regulator fibroblast growth factor-21 in patients with type 2 diabetes and obesity.

26 October 2018

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Fibroblast growth factor 21 reduces the severity of cerulein-induced pancreatitis in mice

26 October 2018

1 reference

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Circulating fibroblast growth factor 21 is induced by peroxisome proliferator-activated receptor agonists but not ketosis in man.

26 October 2018

1 reference

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Fibroblast growth factor 21 reverses hepatic steatosis, increases energy expenditure, and improves insulin sensitivity in diet-induced obese mice

26 October 2018

1 reference

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The circulating metabolic regulator FGF21 is induced by prolonged fasting and PPARalpha activation in man.

26 October 2018

1 reference

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Serum FGF21 levels are increased in obesity and are independently associated with the metabolic syndrome in humans

26 October 2018

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Monoclonal antibody antagonists of hypothalamic FGFR1 cause potent but reversible hypophagia and weight loss in rodents and monkeys

26 October 2018

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Identification of a hormonal basis for gallbladder filling.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4277911

Corticotropin-releasing factor (CRF) acts centrally to inhibit growth hormone secretion in the rat

26 October 2018

1 reference

12 December 2020

Autophagy deficiency leads to protection from obesity and insulin resistance by inducing Fgf21 as a mitokine

1 reference

12 December 2020

Fibroblast growth factor 21 (FGF21) and glucagon-like peptide 1 contribute to diabetes resistance in glucagon receptor-deficient mice

1 reference

12 December 2020

Ectopic recombination in the central and peripheral nervous system by aP2/FABP4-Cre mice: implications for metabolism research

1 reference

12 December 2020

10.1016/J.TEM.2014.10.002

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25476453%20AND%20SRC:MED&resulttype=core&format=json

24 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25476453%20AND%20SRC:MED&resulttype=core&format=json

24 February 2020

PubMed publication ID

25476453

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25476453%20AND%20SRC:MED&resulttype=core&format=json