IKKα negatively regulates ASC-dependent inflammasome activation (Q34982165)

25266676

5 August 2017

title

IKKα negatively regulates ASC-dependent inflammasome activation (English)

1 reference

5 August 2017

1

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4 June 2020

Chen-Hui Wang

2

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Takashi Sato

9

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4 June 2020

Goutham Narla

11

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4 June 2020

George R. Dubyak

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4 June 2020

7

Katarzyna Bulek

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4 June 2020

author name string

Jami Willette-Brown

3

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4 June 2020

Tomasz Herjan

4

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4 June 2020

Muhammet F Gulen

5

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4 June 2020

Hao Zhou

6

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4 June 2020

Luigi Franchi

8

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4 June 2020

Emad S Alnemri

10

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4 June 2020

Xiao-Ping Zhong

12

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4 June 2020

James Thomas

13

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4 June 2020

Dennis Klinman

14

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4 June 2020

Katherine A Fitzgerald

15

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4 June 2020

Gabriel Nuñez

17

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4 June 2020

Yinling Hu

19

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4 June 2020

Xiaoxia Li

20

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4 June 2020

Michael Karin

16

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4 June 2020

language of work or name

English

0 references

publication date

30 September 2014

1 reference

25266676

5 August 2017

published in

Nature Communications

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volume

5

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4 June 2020

page(s)

4977

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IRAK-1 bypasses priming and directly links TLRs to rapid NLRP3 inflammasome activation.

4 June 2020

cites work

1 reference

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Phosphorylation of the adaptor ASC acts as a molecular switch that controls the formation of speck-like aggregates and inflammasome activity

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4298287

Cutting edge: TLR signaling licenses IRAK1 for rapid activation of the NLRP3 inflammasome

8 July 2018

1 reference

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K⁺ efflux is the common trigger of NLRP3 inflammasome activation by bacterial toxins and particulate matter

8 July 2018

1 reference

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Activation and regulation of the inflammasomes

8 July 2018

1 reference

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The pivotal role of IKKα in the development of spontaneous lung squamous cell carcinomas.

8 July 2018

1 reference

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Loss of acinar cell IKKα triggers spontaneous pancreatitis in mice

8 July 2018

1 reference

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IRAK-M mediates Toll-like receptor/IL-1R-induced NFκB activation and cytokine production

8 July 2018

1 reference

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NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS1 mice

8 July 2018

1 reference

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TLR agonists stimulate Nlrp3-dependent IL-1β production independently of the purinergic P2X7 receptor in dendritic cells and in vivo

8 July 2018

1 reference

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Multiple binding sites on the pyrin domain of ASC protein allow self-association and interaction with NLRP3 protein

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4298287

Cutting edge: IL-1β processing during Pseudomonas aeruginosa infection is mediated by neutrophil serine proteases and is independent of NLRC4 and caspase-1.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4298287

NLRP3 inflammasome activity is negatively controlled by miR-223.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4298287

Non-transcriptional priming and deubiquitination regulate NLRP3 inflammasome activation

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4298287

Critical role for calcium mobilization in activation of the NLRP3 inflammasome

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4298287

NLRC4-driven production of IL-1β discriminates between pathogenic and commensal bacteria and promotes host intestinal defense

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4298287

Regulation of inflammasome signaling

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4298287

Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4298287

Inflammasomes in health and disease

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4298287

Sphingosine regulates the NLRP3-inflammasome and IL-1β release from macrophages.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4298287

Crystal Structure of NALP3 Protein Pyrin Domain (PYD) and Its Implications in Inflammasome Assembly

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4298287

Cutting edge: reactive oxygen species inhibitors block priming, but not activation, of the NLRP3 inflammasome

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4298287

Mechanism of impaired NLRP3 inflammasome priming by monophosphoryl lipid A.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4298287

The dual functions of IL-1 receptor-associated kinase 2 in TLR9-mediated IFN and proinflammatory cytokine production

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4298287

The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4298287

Novel cross-talk within the IKK family controls innate immunity

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4298287

NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4298287

Influenza virus activates inflammasomes via its intracellular M2 ion channel

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4298287

The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4298287

The inflammasomes: mechanisms of activation and function

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4298287

Cutting edge: NF-kappaB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4298287

Cutting edge: TNF-alpha mediates sensitization to ATP and silica via the NLRP3 inflammasome in the absence of microbial stimulation

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4298287

Activation of inflammasomes requires intracellular redistribution of the apoptotic speck-like protein containing a caspase recruitment domain

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4298287

Interleukin-1 receptor-associated kinase 2 is critical for lipopolysaccharide-mediated post-transcriptional control.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4298287

AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4298287

AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4298287

Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4298287

Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4298287

Immune recognition of Pseudomonas aeruginosa mediated by the IPAF/NLRC4 inflammasome.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4298287

Multiple functions of the IKK-related kinase IKKepsilon in interferon-mediated antiviral immunity

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4298287

A critical role for I kappaB kinase alpha in the development of human and mouse squamous cell carcinomas

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4298287

Critical role for Cryopyrin/Nalp3 in activation of caspase-1 in response to viral infection and double-stranded RNA

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4298287

Critical role for NALP3/CIAS1/Cryopyrin in innate and adaptive immunity through its regulation of caspase-1

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4298287

Cryopyrin activates the inflammasome in response to toxins and ATP

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4298287

Gout-associated uric acid crystals activate the NALP3 inflammasome

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4298287

Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/Nalp3

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4298287

Genomic structure and functional characterization of the promoter region of human IkappaB kinase-related kinase IKKi/IKKvarepsilon gene.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4298287

The roles of two IkappaB kinase-related kinases in lipopolysaccharide and double stranded RNA signaling and viral infection

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4298287

Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4298287

IKKi/IKKϵ Plays a Key Role in Integrating Signals Induced by Pro-inflammatory Stimuli

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4298287

The PYRIN-CARD protein ASC is an activating adaptor for caspase-1

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4298287

Mutation of a new gene encoding a putative pyrin-like protein causes familial cold autoinflammatory syndrome and Muckle-Wells syndrome

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4298287

Activation by IKKalpha of a second, evolutionary conserved, NF-kappa B signaling pathway

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4298287

Altered cytokine production in mice lacking P2X(7) receptors

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4298287

Abnormal morphogenesis but intact IKK activation in mice lacking the IKKalpha subunit of IkappaB kinase

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4298287

IKK-1 and IKK-2: cytokine-activated IkappaB kinases essential for NF-kappaB activation

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4298287

A cytokine-responsive IkappaB kinase that activates the transcription factor NF-kappaB

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4298287

Potentiation of caspase-1 activation by the P2X7 receptor is dependent on TLR signals and requires NF-kappaB-driven protein synthesis

8 July 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS5977

Deubiquitination of NLRP3 by BRCC3 critically regulates inflammasome activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS5977

Reduction in IkappaB kinase alpha expression promotes the development of skin papillomas and carcinomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS5977

IKKalpha shields 14-3-3sigma, a G(2)/M cell cycle checkpoint gene, from hypermethylation, preventing its silencing.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS5977

Defective lymphotoxin-beta receptor-induced NF-kappaB transcriptional activity in NIK-deficient mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS5977

IKKα limits macrophage NF-κB activation and contributes to the resolution of inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS5977

Heme oxygenase-1, a potential biomarker of chronic silicosis, attenuates silica-induced lung injury

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25266676

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Pannexin-1 is required for ATP release during apoptosis but not for inflammasome activation

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25266676

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NCOMMS5977

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25266676%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

4 June 2020

ADS bibcode

2014NatCo...5.4977M

0 references

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25266676%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

25266676

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25266676%20AND%20SRC:MED&resulttype=core&format=json