3,4-methylenedioxy-β-nitrostyrene inhibits NLRP3 inflammasome activation by blocking assembly of the inflammasome (Q35050189)

24265316

6 August 2017

title

3,4-methylenedioxy-β-nitrostyrene inhibits NLRP3 inflammasome activation by blocking assembly of the inflammasome (English)

1 reference

6 August 2017

1 reference

Yuan He

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24265316%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

Saranyaraajan Varadarajan

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24265316%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

Raúl Muñoz-Planillo

series ordinal

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24265316%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

Aaron Burberry

series ordinal

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24265316%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

language of work or name

English

0 references

publication date

21 November 2013

1 reference

24265316

Journal of Biological Chemistry

6 August 2017

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24265316%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

volume

289

1 reference

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8 June 2020

issue

2

1 reference

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8 June 2020

page(s)

1142-1150

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24265316%20AND%20SRC:MED&resulttype=core&format=json

K⁺ efflux is the common trigger of NLRP3 inflammasome activation by bacterial toxins and particulate matter

8 June 2020

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8 July 2018

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Deubiquitinases regulate the activity of caspase-1 and interleukin-1β secretion via assembly of the inflammasome

8 July 2018

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8 July 2018

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Phosphorylation of NLRC4 is critical for inflammasome activation

8 July 2018

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8 July 2018

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NLRC4-driven production of IL-1β discriminates between pathogenic and commensal bacteria and promotes host intestinal defense

8 July 2018

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8 July 2018

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Sensing and reacting to microbes through the inflammasomes

8 July 2018

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The cytokine release inhibitory drug CRID3 targets ASC oligomerisation in the NLRP3 and AIM2 inflammasomes

8 July 2018

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8 July 2018

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Chemical probing reveals insights into the signaling mechanism of inflammasome activation

8 July 2018

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Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes

8 July 2018

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NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

8 July 2018

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8 July 2018

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Anti-inflammatory compounds parthenolide and Bay 11-7082 are direct inhibitors of the inflammasome

8 July 2018

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Glyburide inhibits the Cryopyrin/Nalp3 inflammasome

8 July 2018

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Cutting edge: NF-kappaB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression

8 July 2018

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Cutting edge: TNF-alpha mediates sensitization to ATP and silica via the NLRP3 inflammasome in the absence of microbial stimulation

8 July 2018

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8 July 2018

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The inflammasomes: guardians of the body

8 July 2018

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AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA

8 July 2018

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AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC

8 July 2018

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Selectivity and mechanism of action of a growth factor receptor-bound protein 2 SRC homology 2 domain binding antagonist

8 July 2018

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Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization

8 July 2018

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8 July 2018

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The Nalp3 inflammasome is essential for the development of silicosis

8 July 2018

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8 July 2018

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Activation of the NALP3 inflammasome is triggered by low intracellular potassium concentration

8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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Potent Inhibition of Human Telomerase by Nitrostyrene Derivatives

8 July 2018

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Chronic infantile neurological cutaneous and articular syndrome is caused by mutations in CIAS1, a gene highly expressed in polymorphonuclear cells and chondrocytes

8 July 2018

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Mutation of a new gene encoding a putative pyrin-like protein causes familial cold autoinflammatory syndrome and Muckle-Wells syndrome

8 July 2018

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Differential requirement of P2X7 receptor and intracellular K+ for caspase-1 activation induced by intracellular and extracellular bacteria

8 July 2018

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Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defence

21 January 2018

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Deubiquitination of NLRP3 by BRCC3 critically regulates inflammasome activity.

21 January 2018

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Structure activity analysis of the pro-apoptotic, antitumor effect of nitrostyrene adducts and related compounds

21 January 2018

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Prevention of platelet glycoprotein IIb/IIIa activation by 3,4-methylenedioxy-beta-nitrostyrene, a novel tyrosine kinase inhibitor

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24265316

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Synthesis and pharmacological evaluation of novel beta-nitrostyrene derivatives as tyrosine kinase inhibitors with potent antiplatelet activity

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24265316

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1074/JBC.M113.515080

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24265316%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24265316%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

24265316

1 reference