The tumor suppressor gene Trp53 protects the mouse lens against posterior subcapsular cataracts and the BMP receptor Acvr1 acts as a tumor suppressor in the lens. (Q35070724)

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English	The tumor suppressor gene Trp53 protects the mouse lens against posterior subcapsular cataracts and the BMP receptor Acvr1 acts as a tumor suppressor in the lens.	scientific article

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29 January 2020

The tumor suppressor gene Trp53 protects the mouse lens against posterior subcapsular cataracts and the BMP receptor Acvr1 acts as a tumor suppressor in the lens (English)

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29 January 2020

1

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29 January 2020

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Ramya Rajagopal

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29 January 2020

Lisa K Dattilo

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29 January 2020

David C Beebe

4

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29 January 2020

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18 April 2011

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29 January 2020

Disease Models & Mechanisms

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29 January 2020

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29 January 2020

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29 January 2020

484-495

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29 January 2020

Current strategies to target p53 in cancer.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124053

8 July 2018

The tumor suppressor merlin is required for cell cycle exit, terminal differentiation, and cell polarity in the developing murine lens

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124053

8 July 2018

Activin signaling in microsatellite stable colon cancers is disrupted by a combination of genetic and epigenetic mechanisms.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124053

8 July 2018

p53 brings a new twist to the Smad signaling network

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124053

8 July 2018

Functions of the type 1 BMP receptor Acvr1 (Alk2) in lens development: cell proliferation, terminal differentiation, and survival

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124053

8 July 2018

Fibroblast growth factor receptor signaling is essential for lens fiber cell differentiation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124053

8 July 2018

Chromatin-bound p53 anchors activated Smads and the mSin3A corepressor to confer transforming-growth-factor-beta-mediated transcription repression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124053

8 July 2018

Epidemiology of cataract: accomplishments over 25 years and future directions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124053

8 July 2018

Integration of TGF-beta and Ras/MAPK signaling through p53 phosphorylation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124053

8 July 2018

Intravitreal triamcinolone acetonide: a change in a paradigm

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124053

8 July 2018

Müllerian inhibiting substance regulates its receptor/SMAD signaling and causes mesenchymal transition of the coelomic epithelial cells early in Müllerian duct regression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124053

8 July 2018

The P53 pathway: what questions remain to be explored?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124053

8 July 2018

Frequency of cataract surgery after intravitreal injection of high-dosage triamcinolone acetonide.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124053

8 July 2018

Role of type I receptors for anti-Müllerian hormone in the SMAT-1 Sertoli cell line.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124053

8 July 2018

Hypoxia-induced nucleophosmin protects cell death through inhibition of p53.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124053

8 July 2018

Craniofacial defects in mice lacking BMP type I receptor Alk2 in neural crest cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124053

8 July 2018

Bmp signaling is required for development of primary lens fiber cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124053

8 July 2018

Germline mutations in BMPR1A/ALK3 cause a subset of cases of juvenile polyposis syndrome and of Cowden and Bannayan-Riley-Ruvalcaba syndromes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124053

8 July 2018

Cataract blindness--challenges for the 21st century

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124053

8 July 2018

Pax6 activity in the lens primordium is required for lens formation and for correct placement of a single retina in the eye

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124053

8 July 2018

Regulation of mouse lens fiber cell development and differentiation by the Maf gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124053

8 July 2018

Prox1 function is crucial for mouse lens-fibre elongation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124053

8 July 2018

Cooperation between the Cdk inhibitors p27(KIP1) and p57(KIP2) in the control of tissue growth and development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124053

8 July 2018

Sox1 directly regulates the gamma-crystallin genes and is essential for lens development in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124053

8 July 2018

DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124053

8 July 2018

Involvement of p53 in cell differentiation and development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124053

8 July 2018

Mdm2 promotes the rapid degradation of p53

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124053

8 July 2018

Chromatin degradation in differentiating fiber cells of the eye lens.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124053

8 July 2018

Tumorigenicity by human papillomavirus type 16 E6 and E7 in transgenic mice correlates with alterations in epithelial cell growth and differentiation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124053

8 July 2018

p53-dependent apoptosis produced by Rb-deficiency in the developing mouse lens.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124053

8 July 2018

Mice Lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124053

8 July 2018

Radiation-induced cell cycle arrest compromised by p21 deficiency

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124053

8 July 2018

Oncogenesis of the lens in transgenic mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124053

8 July 2018

Differentiation and oncogenesis: phenotypically distinct lens tumors in transgenic mice

1 reference

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8 July 2018

Lens epithelium and radiation cataract. I. Preliminary studies

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124053

8 July 2018

Posterior subcapsular cataracts: histopathologic study of steroid-associated cataracts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124053

8 July 2018

Lower intraocular oxygen tension in diabetic patients: possible contribution to decreased incidence of nuclear sclerotic cataract.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124053

27 September 2018

Oxygen distribution in the rabbit eye and oxygen consumption by the lens.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124053

27 September 2018

Signaling through FGF receptor-2 is required for lens cell survival and for withdrawal from the cell cycle during lens fiber cell differentiation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124053

27 September 2018

Intravitreal triamcinolone-induced elevated intraocular pressure is associated with the development of posterior subcapsular cataract

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124053

27 September 2018

Hypoxia attenuates the p53 response to cellular damage

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124053

27 September 2018

Fgf receptor signaling plays a role in lens induction.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124053

27 September 2018

Synergistic tumor suppressor activity of BRCA2 and p53 in a conditional mouse model for breast cancer.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124053

27 September 2018

Germline mutations of the gene encoding bone morphogenetic protein receptor 1A in juvenile polyposis.

1 reference

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27 September 2018

Preparation of PCR-quality mouse genomic DNA with hot sodium hydroxide and tris (HotSHOT).

1 reference

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27 September 2018

Temporally distinct patterns of p53-dependent and p53-independent apoptosis during mouse lens development

1 reference

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27 September 2018

Effects of beta irradiation on the rabbit lens

1 reference

https://pubmed.ncbi.nlm.nih.gov/21504908

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lens membranes II. Isolation and characterization of the main intrinsic polypeptide (MIP) of bovine lens fiber membranes

1 reference

https://pubmed.ncbi.nlm.nih.gov/21504908

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

E2F1 mediates ectopic proliferation and stage-specific p53-dependent apoptosis but not aberrant differentiation in the ocular lens of Rb deficient fetuses

1 reference

https://pubmed.ncbi.nlm.nih.gov/21504908

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of high-energy particles, X-rays, and aging on lens epithelium

1 reference

https://pubmed.ncbi.nlm.nih.gov/21504908

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cataract formation and other complications of intravitreal triamcinolone for macular edema

1 reference

https://pubmed.ncbi.nlm.nih.gov/21504908

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Universal PCR genotyping assay that achieves single copy sensitivity with any primer pair

1 reference

https://pubmed.ncbi.nlm.nih.gov/21504908

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human posterior subcapsular cataract. A gross and flat preparation study

1 reference

https://pubmed.ncbi.nlm.nih.gov/21504908

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of cell death by lens-specific overexpression of bcl-2 in transgenic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/21504908

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human posterior subcapsular cataract. An ultrastructural study of the posteriorly migrating cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/21504908

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hypophysectomy exerts a radioprotective effect on frog lens

1 reference

https://pubmed.ncbi.nlm.nih.gov/21504908

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1242/DMM.006593

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21504908%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21504908%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21504908%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

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