Activating FLT3 mutants show distinct gain-of-function phenotypes in vitro and a characteristic signaling pathway profile associated with prognosis in acute myeloid leukemia (Q35114397)

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English	Activating FLT3 mutants show distinct gain-of-function phenotypes in vitro and a characteristic signaling pathway profile associated with prognosis in acute myeloid leukemia	scientific article

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6 August 2017

Activating FLT3 mutants show distinct gain-of-function phenotypes in vitro and a characteristic signaling pathway profile associated with prognosis in acute myeloid leukemia (English)

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6 August 2017

Karl-Peter Hopfner

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9 June 2020

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9 June 2020

Stefan Bohlander

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9 June 2020

Wolfgang Hiddemann

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Wolfgang Hiddemann

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9 June 2020

Friederike Pastore

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9 June 2020

Bernhard J Woermann

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Bernhard J Woermann

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Hanna Janke

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9 June 2020

Daniela Schumacher

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9 June 2020

Stephanie Schneider

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9 June 2020

Wolfgang E Berdel

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9 June 2020

Thomas Büchner

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9 June 2020

Marion Subklewe

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9 June 2020

Karsten Spiekermann

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9 June 2020

Harald Polzer

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9 June 2020

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7 March 2014

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6 August 2017

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9 June 2020

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9 June 2020

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9 June 2020

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9 June 2020

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Creative Commons Attribution 4.0 International

7 March 2014

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22 June 2022

https://europepmc.org/article/PMC/3946485

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Identification of a 24-gene prognostic signature that improves the European LeukemiaNet risk classification of acute myeloid leukemia: an international collaborative study

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9 July 2018

Autotaxin is expressed in FLT3-ITD positive acute myeloid leukemia and hematopoietic stem cells and promotes cell migration and proliferation

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9 July 2018

Casitas B-lineage lymphoma mutants activate AKT to induce transformation in cooperation with class III receptor tyrosine kinases

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9 July 2018

Suppressor of cytokine signaling 6 (SOCS6) negatively regulates Flt3 signal transduction through direct binding to phosphorylated tyrosines 591 and 919 of Flt3.

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9 July 2018

Adaptor protein Lnk binds to and inhibits normal and leukemic FLT3.

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9 July 2018

SRC is a signaling mediator in FLT3-ITD- but not in FLT3-TKD-positive AML.

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Enhanced activation of STAT pathways and overexpression of survivin confer resistance to FLT3 inhibitors and could be therapeutic targets in AML.

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9 July 2018

Transformation by oncogenic mutants and ligand-dependent activation of FLT3 wild-type requires the tyrosine residues 589 and 591.

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9 July 2018

Prognostic relevance of FLT3-TKD mutations in AML: the combination matters--an analysis of 3082 patients

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9 July 2018

Recent advances in the understanding of mastocytosis: the role of KIT mutations.

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9 July 2018

Activation mechanisms of STAT5 by oncogenic Flt3-ITD.

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9 July 2018

FLT3 K663Q is a novel AML-associated oncogenic kinase: Determination of biochemical properties and sensitivity to Sunitinib (SU11248).

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9 July 2018

Roles of tyrosine 589 and 591 in STAT5 activation and transformation mediated by FLT3-ITD.

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9 July 2018

Point mutations in the juxtamembrane domain of FLT3 define a new class of activating mutations in AML.

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9 July 2018

FMS-like tyrosine kinase 3 in normal hematopoiesis and acute myeloid leukemia

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9 July 2018

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9 July 2018

Clinical resistance to the kinase inhibitor PKC412 in acute myeloid leukemia by mutation of Asn-676 in the FLT3 tyrosine kinase domain

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9 July 2018

Signal transduction of oncogenic Flt3.

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9 July 2018

Tyrosine phosphorylation regulates maturation of receptor tyrosine kinases

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9 July 2018

AML-associated Flt3 kinase domain mutations show signal transduction differences compared with Flt3 ITD mutations.

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9 July 2018

Identification of a novel activating mutation (Y842C) within the activation loop of FLT3 in patients with acute myeloid leukemia (AML).

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9 July 2018

The structural basis for autoinhibition of FLT3 by the juxtamembrane domain

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9 July 2018

Pretreatment cytogenetic abnormalities are predictive of induction success, cumulative incidence of relapse, and overall survival in adult patients with de novo acute myeloid leukemia: results from Cancer and Leukemia Group B (CALGB 8461)

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9 July 2018

The roles of FLT3 in hematopoiesis and leukemia

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Analysis of FLT3 length mutations in 1003 patients with acute myeloid leukemia: correlation to cytogenetics, FAB subtype, and prognosis in the AMLCG study and usefulness as a marker for the detection of minimal residual disease

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Analysis of FLT3-activating mutations in 979 patients with acute myelogenous leukemia: association with FAB subtypes and identification of subgroups with poor prognosis

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FLT3 internal tandem duplication mutations associated with human acute myeloid leukemias induce myeloproliferative disease in a murine bone marrow transplant model

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Activating mutation of D835 within the activation loop of FLT3 in human hematologic malignancies

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Constitutive activation of FLT3 in acute myeloid leukaemia and its consequences for growth of 32D cells

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Identification of driver and passenger mutations of FLT3 by high-throughput DNA sequence analysis and functional assessment of candidate alleles

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FLT3 and NPM1 mutations in a cohort of AML patients and detection of a novel mutation in tyrosine kinase domain of FLT3 gene from Western India

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21 January 2018

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FLT3-ITD and tyrosine kinase domain mutants induce 2 distinct phenotypes in a murine bone marrow transplantation model

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21 January 2018

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27 September 2018

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27 September 2018

6-Thioguanine, cytarabine, and daunorubicin (TAD) and high-dose cytarabine and mitoxantrone (HAM) for induction, TAD for consolidation, and either prolonged maintenance by reduced monthly TAD or TAD-HAM-TAD and one course of intensive consolidation

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Development of a human acute myeloid leukaemia screening panel and consequent identification of novel gene mutation in FLT3 and CCND3

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https://pubmed.ncbi.nlm.nih.gov/24608088

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Double induction containing either two courses or one course of high-dose cytarabine plus mitoxantrone and postremission therapy by either autologous stem-cell transplantation or by prolonged maintenance for acute myeloid leukemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/24608088

12 December 2020

based on heuristic

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1 reference

https://pubmed.ncbi.nlm.nih.gov/24608088

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

FLT3 tyrosine kinase domain mutations are biologically distinct from and have a significantly more favorable prognosis than FLT3 internal tandem duplications in patients with acute myeloid leukemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/24608088

12 December 2020

based on heuristic

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9 June 2020

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9 June 2020

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9 June 2020

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