Inhibitor of kappa B epsilon (IκBε) is a non-redundant regulator of c-Rel-dependent gene expression in murine T and B cells (Q35198965)

7 August 2017

title

Inhibitor of kappa B epsilon (IκBε) is a non-redundant regulator of c-Rel-dependent gene expression in murine T and B cells (English)

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7 August 2017

Sylvie Mémet

7

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Andrew P Cope

object named as

Andrew P Cope

8

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author name string

Joanna M Clark

1

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7 August 2017

Karolina Aleksiyadis

2

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7 August 2017

Alex Martin

3

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7 August 2017

Kay McNamee

4

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7 August 2017

Tharsana Tharmalingam

5

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7 August 2017

Richard O Williams

6

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7 August 2017

language of work or name

English

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publication date

6 September 2011

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7 August 2017

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7 August 2017

volume

6

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7 August 2017

issue

9

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7 August 2017

page(s)

e24504

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Creative Commons Attribution 4.0 International

7 August 2017

copyright license

start time

6 September 2011

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April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

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Gene discovery in rheumatoid arthritis highlights the CD40/NF-kappaB signaling pathway in disease pathogenesis

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REL, encoding a member of the NF-kappaB family of transcription factors, is a newly defined risk locus for rheumatoid arthritis

28 July 2018

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Molecular mechanism and function of CD40/CD40L engagement in the immune system.

28 July 2018

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Regulation and function of NF-kappaB transcription factors in the immune system

28 July 2018

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BAFF-R promotes cell proliferation and survival through interaction with IKKbeta and NF-kappaB/c-Rel in the nucleus of normal and neoplastic B-lymphoid cells

28 July 2018

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Protein phosphatase 6 regulatory subunits composed of ankyrin repeat domains

28 July 2018

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Genome-wide analysis of gene expression in T cells to identify targets of the NF-kappa B transcription factor c-Rel

28 July 2018

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Distinct roles of different NF-kappa B subunits in regulating inflammatory and T cell stimulatory gene expression in dendritic cells

28 July 2018

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Unravelling the complexities of the NF-kappaB signalling pathway using mouse knockout and transgenic models.

28 July 2018

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Protein phosphatase 6 subunit with conserved Sit4-associated protein domain targets IkappaBepsilon

28 July 2018

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IkappaBepsilon provides negative feedback to control NF-kappaB oscillations, signaling dynamics, and inflammatory gene expression.

28 July 2018

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Differential effects of tumor necrosis factor-alpha and CD40L on NF-kappa B inhibitory proteins I kappa B alpha, beta and epsilon and on the induction of the Jun amino-terminal kinase pathway in Ramos Burkitt lymphoma cells.

28 July 2018

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Identification of direct genomic targets downstream of the nuclear factor-kappaB transcription factor mediating tumor necrosis factor signaling.

28 July 2018

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Reductions in I kappa B epsilon and changes in NF-kappa B activity during B lymphocyte differentiation.

28 July 2018

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28 July 2018

Signaling to NF-kappaB

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The two NF-kappaB activation pathways and their role in innate and adaptive immunity

28 July 2018

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CD40/CD154 interactions at the interface of tolerance and immunity

28 July 2018

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T cell receptor zeta reconstitution fails to restore responses of T cells rendered hyporesponsive by tumor necrosis factor alpha

28 July 2018

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A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway

28 July 2018

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IkappaBalpha/IkappaBepsilon deficiency reveals that a critical NF-kappaB dosage is required for lymphocyte survival.

28 July 2018

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Distinctions between c-Rel and other NF-kappaB proteins in immunity and disease

28 July 2018

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NF-kappaB regulation in the immune system

28 July 2018

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Studies of T-cell activation in chronic inflammation

28 July 2018

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Characterization of the nuclear import and export functions of Ikappa B(epsilon).

28 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3167847

IkappaBbeta, but not IkappaBalpha, functions as a classical cytoplasmic inhibitor of NF-kappaB dimers by masking both NF-kappaB nuclear localization sequences in resting cells

28 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3167847

Partners in transcription: NFAT and AP-1.

28 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3167847

The 3' untranslated region of tumor necrosis factor alpha mRNA is a target of the mRNA-stabilizing factor HuR.

28 July 2018

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IkappaB family members function by different mechanisms

28 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3167847

Common pathway for the ubiquitination of IkappaBalpha, IkappaBbeta, and IkappaBepsilon mediated by the F-box protein FWD1.

28 July 2018

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T cell responses to a human cartilage autoantigen in the context of rheumatoid arthritis-associated and nonassociated HLA-DR4 alleles

28 July 2018

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The crystal structure of the IkappaBalpha/NF-kappaB complex reveals mechanisms of NF-kappaB inactivation

28 July 2018

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Cloning and functional characterization of mouse IkappaBepsilon

28 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3167847

A new member of the I kappaB protein family, I kappaB epsilon, inhibits RelA (p65)-mediated NF-kappaB transcription

28 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3167847

Distinct functional properties of IkappaB alpha and IkappaB beta

28 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3167847

CD28 mediates transcriptional upregulation of the interleukin-2 (IL-2) promoter through a composite element containing the CD28RE and NF-IL-2B AP-1 sites

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3167847

I kappa B epsilon, a novel member of the I kappa B family, controls RelA and cRel NF-kappa B activity

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3167847

rel/NF-kappa B nuclear complexes that bind kB sites in the murine c-rel promoter are required for constitutive c-rel transcription in B-cells.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3167847

Chronic exposure to tumor necrosis factor (TNF) in vitro impairs the activation of T cells through the T cell receptor/CD3 complex; reversal in vivo by anti-TNF antibodies in patients with rheumatoid arthritis

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3167847

Role of unphosphorylated, newly synthesized I kappa B beta in persistent activation of NF-kappa B

28 July 2018

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0024504

The c-Rel transcription factor and B-cell proliferation: a deal with the devil

21 January 2018

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0024504

B cell receptor-mediated sustained c-Rel activation facilitates late transitional B cell survival through control of B cell activating factor receptor and NF-kappaB2.

21 January 2018

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0024504

BAFF mediates survival of peripheral immature B lymphocytes

21 January 2018

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0024504

Nuclear CD40 interacts with c-Rel and enhances proliferation in aggressive B-cell lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0024504

Prolonged exposure of T cells to TNF down-regulates TCR zeta and expression of the TCR/CD3 complex at the cell surface.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0024504

Nuclear actin and actin-related proteins in chromatin remodeling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0024504

The mitogen-induced increase in T cell size involves PKC and NFAT activation of Rel/NF-kappaB-dependent c-myc expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0024504

Multiple roles of the NF-kappaB signaling pathway regulated by coupled negative feedback circuits

21 January 2018

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0024504

Detecting shared pathogenesis from the shared genetics of immune-related diseases

21 January 2018

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0024504

21 January 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3167847

c-Rel-dependent priming of naive T cells by inflammatory cytokines

26 September 2018

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12 December 2020

IkappaBepsilon-deficient mice: reduction of one T cell precursor subspecies and enhanced Ig isotype switching and cytokine synthesis

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12 December 2020

The Presumed Hyporesponsive Behavior of Rheumatoid Arthritis T Lymphocytes Can Be Attributed to Spontaneous Ex Vivo Apoptosis rather than Defects in T Cell Receptor Signaling

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12 December 2020

The human IL-2 gene promoter can assemble a positioned nucleosome that becomes remodeled upon T cell activation

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12 December 2020

c-Rel is required for chromatin remodeling across the IL-2 gene promoter

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12 December 2020

Differential regulation of c-Rel translocation in activated B and T cells

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12 December 2020

Involvement of Rel, Fos, and Jun proteins in binding activity to the IL-2 promoter CD28 response element/AP-1 sequence in human T cells

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12 December 2020

c-Rel is crucial for lymphocyte proliferation but dispensable for T cell effector function

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12 December 2020

Constitutive nuclear translocation of NF-kappa B in B cells in the absence of I kappa B degradation

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12 December 2020

10.1371/JOURNAL.PONE.0024504

Identifiers

DOI

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7 August 2017

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7 August 2017

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