Chemical structures and biological activities of non-peptide selective kappa opioid ligands (Q35237319)

7 August 2017

1 reference

title

Chemical structures and biological activities of non-peptide selective kappa opioid ligands (English)

1 reference

7 August 2017

D. C. Rees

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A1335584

15 September 2022

language of work or name

English

1 reference

National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=1335584

15 September 2022

publication date

1 January 1992

1 reference

Progress in medicinal chemistry

7 August 2017

published in

1 reference

7 August 2017

volume

29

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7 August 2017

page(s)

109-139

1 reference

Selective opioid receptor agonists and antagonists: research tools and potential therapeutic agents

7 August 2017

cites work

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[3H]U-69593 a highly selective ligand for the opioid kappa receptor

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Benzeneacetamide amines: structurally novel non-m.mu. opioids

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Properties of a selective kappa agonist, U-50,488H

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Compounds of novel structure having kappa-agonist behavioral effects in rhesus monkeys

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An opioid benzodiazepine

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Dynorphin1–8 and dynorphin1–9 are ligands for the κ-subtype of opiate receptor

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Characterization and visualization of rat and guinea pig brain kappa opioid receptors: evidence for kappa 1 and kappa 2 opioid receptors

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Computer modeling of subtypes of kappa opioid receptors in adrenal medulla

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Pharmacological profile of PD 117302, a selective kappa-opioid agonist

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Behavioral effects of a novel kappa opioid analgesic, U-50488, in rats and rhesus monkeys

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Kappa receptor mediated opioid dependence in rhesus monkeys

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Psychotomimesis mediated by kappa opiate receptors

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Opiate antagonist improves neurologic recovery after spinal injury

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Cardiovascular consequences of endogenous opiate antagonism

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Protection from cerebral ischemia by U-50,488E, a specific kappa opioid analgesic agent

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Protection from ischemia-induced cerebral edema in the rat by U-50488H, a kappa opioid receptor agonist

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Beneficial effects of the kappa opioid receptor agonist U-50488H in experimental acute brain and spinal cord injury

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7 January 2021

PD117302, a selective non-peptide opioid kappa agonist, protects against NMDA and maximal electroshock convulsions in rats

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The anticonvulsant action of CI-977, a selective kappa-opioid receptor agonist: a possible involvement of the glycine/NMDA receptor complex

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Kappa opioid receptor activation depresses excitatory synaptic input to rat locus coeruleus neurons in vitro

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7 January 2021

Correlation of ontogeny with function of [3H]U69593 labelled kappa opioid binding sites in the rat spinal cord

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7 January 2021

Conformational characteristics of opioid kappa-receptor agonist: crystal structure of (5S,7S,8S)-(-)-N-methyl-N-[7-(1-pyrrolidinyl)-1- oxaspiro[4.5]dec-8-yl]benzeneacetamide (U69,593), and conformational comparison with some kappa-agonists

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7 January 2021

Highly selective kappa opioid analgesics. Synthesis and structure-activity relationships of novel N-[(2-aminocyclohexyl)aryl]acetamide and N-[(2-aminocyclohexyl)aryloxy]acetamide derivatives

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7 January 2021

PD117302: a selective agonist for the kappa-opioid receptor

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An in vitro profile of activity for the (+) and (-) enantiomers of spiradoline and PD117302.

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Selective and enantiospecific acylation of kappa opioid receptors by (1S,2S)-trans-2-isothiocyanato-N-methyl-N-[2-(1-pyrrolidinyl) cyclohexy l] benzeneacetamide. Demonstration of kappa receptor heterogeneity

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Highly selective kappa-opioid analgesics. 2. Synthesis and structure-activity relationships of novel N-[(2-aminocyclohexyl)aryl]acetamide derivatives

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7 January 2021

Highly selective .kappa. opioid analgesics. 4. Synthesis of some conformationally restricted naphthalene derivatives with high receptor affinity and selectivity

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7 January 2021

Highly selective kappa-opioid analgesics. 3. Synthesis and structure-activity relationships of novel N-[2-(1-pyrrolidinyl)-4- or -5-substituted-cyclohexyl]arylacetamide derivatives

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7 January 2021

CI-977, a novel and selective agonist for the kappa-opioid receptor

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Synthesis of (1',2'-trans)-3-phenyl-1-[2'-(N-pyrrolidinyl)cyclohexyl]pyrrolid -2-ones as kappa-selective opiates

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7 January 2021

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7 January 2021

Alterations in the stereochemistry of the kappa-selective opioid agonist U50,488 result in high-affinity sigma ligands

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

Cholecystokinin-A receptor ligands based on the kappa-opioid agonist tifluadom

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7 January 2021

The binding spectrum of narcotic analgesic drugs with different agonist and antagonist properties

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7 January 2021

Nitrogen-bridged conformationally constrained etorphine analogues. Synthesis and biological evaluation

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7 January 2021

Binaltorphimine and nor-binaltorphimine, potent and selective kappa-opioid receptor antagonists

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7 January 2021

10.1016/S0079-6468(08)70006-7

Identifiers

DOI

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