An update on the genetic architecture of hyperuricemia and gout (Q35359040)

7 August 2017

13 references

13 March 2019

24 March 2019

22 April 2019

17 June 2019

19 September 2019

28 November 2019

15 December 2019

18 December 2019

23 July 2020

11 August 2020

10 September 2020

6 July 2021

28 November 2023

An update on the genetic architecture of hyperuricemia and gout (English)

1 reference

biomedical investigative technique

7 August 2017

11 references

13 March 2019

24 March 2019

22 April 2019

17 June 2019

19 September 2019

28 November 2019

15 December 2019

18 December 2019

23 July 2020

11 August 2020

10 September 2020

10 references

13 March 2019

24 March 2019

22 April 2019

17 June 2019

19 September 2019

28 November 2019

15 December 2019

18 December 2019

23 July 2020

11 August 2020

1 reference

19 September 2019

1 reference

28 November 2019

1 reference

15 December 2019

1 reference

18 December 2019

genetic predisposition to disease

2 references

23 July 2020

10 September 2020

genome-wide association study

1 reference

PubMed

ATP-binding cassette transporter

11 August 2020

1 reference

6 July 2021

Tony R Merriman

1

0 references

language of work or name

1 reference

10 April 2015

13 references

Arthritis Research and Therapy

7 August 2017

13 March 2019

24 March 2019

22 April 2019

17 June 2019

19 September 2019

28 November 2019

15 December 2019

18 December 2019

23 July 2020

11 August 2020

6 July 2021

28 November 2023

13 references

7 August 2017

13 March 2019

24 March 2019

22 April 2019

17 June 2019

19 September 2019

28 November 2019

15 December 2019

18 December 2019

23 July 2020

11 August 2020

6 July 2021

28 November 2023

17

1 reference

7 August 2017

page(s)

98

1 reference

Creative Commons Attribution

7 August 2017

copyright license

12 references

13 March 2019

24 March 2019

22 April 2019

17 June 2019

19 September 2019

28 November 2019

15 December 2019

18 December 2019

23 July 2020

11 August 2020

6 July 2021

28 November 2023

0 references

on focus list of Wikimedia project

ScienceSource

0 references

cites work

Mendelian randomization provides no evidence for a causal role of serum urate in increasing serum triglyceride levels

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12 July 2018

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Copy number polymorphisms near SLC2A9 are associated with serum uric acid concentrations

12 July 2018

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12 July 2018

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12 July 2018

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12 July 2018

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Abundant local interactions in the 4p16.1 region suggest functional mechanisms underlying SLC2A9 associations with human serum uric acid

12 July 2018

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12 July 2018

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12 July 2018

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Gene-centric meta-analysis in 87,736 individuals of European ancestry identifies multiple blood-pressure-related loci

12 July 2018

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Influence of the ABCG2 gout risk 141 K allele on urate metabolism during a fructose challenge

12 July 2018

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Expression of SLC2A9 isoforms in the kidney and their localization in polarized epithelial cells

12 July 2018

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Hyperuricaemia in the Pacific: why the elevated serum urate levels?

12 July 2018

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Association analysis of the SLC22A11 (organic anion transporter 4) and SLC22A12 (urate transporter 1) urate transporter locus with gout in New Zealand case-control sample sets reveals multiple ancestral-specific effects

12 July 2018

1 reference

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Association of the lipoprotein receptor-related protein 2 gene with gout and non-additive interaction with alcohol consumption

12 July 2018

1 reference

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Sugar-sweetened beverage consumption: a risk factor for prevalent gout with SLC2A9 genotype-specific effects on serum urate and risk of gout

12 July 2018

1 reference

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Association of plasma uric acid with ischaemic heart disease and blood pressure: mendelian randomisation analysis of two large cohorts

12 July 2018

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Association of TLR4 Gene rs2149356 polymorphism with primary gouty arthritis in a case-control study

12 July 2018

1 reference

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Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture

12 July 2018

1 reference

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Gout-causing Q141K mutation in ABCG2 leads to instability of the nucleotide-binding domain and can be corrected with small molecules

12 July 2018

1 reference

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Genome-wide association analyses identify 18 new loci associated with serum urate concentrations

12 July 2018

1 reference

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Systematic localization of common disease-associated variation in regulatory DNA

12 July 2018

1 reference

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The genetics of hyperuricaemia and gout

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4392805

Meta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4392805

A urate gene-by-diuretic interaction and gout risk in participants with hypertension: results from the ARIC study

12 July 2018

1 reference

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Human SLC2A9a and SLC2A9b isoforms mediate electrogenic transport of urate with different characteristics in the presence of hexoses

12 July 2018

1 reference

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The renal urate transporter SLC17A1 locus: confirmation of association with gout

12 July 2018

1 reference

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Decreased extra-renal urate excretion is a common cause of hyperuricemia

12 July 2018

1 reference

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National prevalence of gout derived from administrative health data in Aotearoa New Zealand

12 July 2018

1 reference

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Multiple genetic loci influence serum urate levels and their relationship with gout and cardiovascular disease risk factors

12 July 2018

1 reference

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Theodore E. Woodward award. The evolution of obesity: insights from the mid-Miocene

12 July 2018

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The genetic basis of hyperuricaemia and gout

12 July 2018

1 reference

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Bayesian methods for instrumental variable analysis with genetic instruments ('Mendelian randomization'): example with urate transporter SLC2A9 as an instrumental variable for effect of urate levels on metabolic syndrome

12 July 2018

1 reference

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Finding the missing heritability of complex diseases

12 July 2018

1 reference

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Recent insights into the pathogenesis of hyperuricaemia and gout

12 July 2018

1 reference

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Glut9 is a major regulator of urate homeostasis and its genetic inactivation induces hyperuricosuria and urate nephropathy

12 July 2018

1 reference

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Solute carrier family 2, member 9 and uric acid homeostasis

12 July 2018

1 reference

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Identifying relationships among genomic disease regions: predicting genes at pathogenic SNP associations and rare deletions

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4392805

Identification of a urate transporter, ABCG2, with a common functional polymorphism causing gout

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4392805

Meta-analysis of 28,141 individuals identifies common variants within five new loci that influence uric acid concentrations

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4392805

Crystal ball gazing: new therapeutic targets for hyperuricaemia and gout

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4392805

SLC2A9 is a high-capacity urate transporter in humans

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4392805

Association of three genetic loci with uric acid concentration and risk of gout: a genome-wide association study

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4392805

SLC2A9 is a newly identified urate transporter influencing serum urate concentration, urate excretion and gout

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4392805

SLC2A9 influences uric acid concentrations with pronounced sex-specific effects

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4392805

Sugar-sweetened soft drinks, diet soft drinks, and serum uric acid level: the Third National Health and Nutrition Examination Survey

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4392805

Uric acid provides an antioxidant defense in humans against oxidant- and radical-caused aging and cancer: a hypothesis

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4392805

Asymptomatic hyperuricemia. Risks and consequences in the Normative Aging Study

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4392805

Twenty-eight loci that influence serum urate levels: analysis of association with gout.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4392805

Early-onset metabolic syndrome in mice lacking the intestinal uric acid transporter SLC2A9.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4392805

Mendelian randomization analysis associates increased serum urate, due to genetic variation in uric acid transporters, with improved renal function

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4392805

Effect of genetic polymorphisms on development of gout

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4392805

Nature versus nurture in gout: a twin study.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4392805

Role of the urate transporter SLC2A9 gene in susceptibility to gout in New Zealand Māori, Pacific Island, and Caucasian case-control sample sets

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4392805

Sodium-dependent phosphate cotransporter type 1 sequence polymorphisms in male patients with gout.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4392805

A prospective study of gout and cancer

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4392805

Population-specific influence ofSLC2A9genotype on the acute hyperuricaemic response to a fructose load

26 September 2018

1 reference

https://api.crossref.org/works/10.1186%2FS13075-015-0609-2

Evidence for an influence of chemokine ligand 3-like 1 (CCL3L1) gene copy number on susceptibility to rheumatoid arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2FS13075-015-0609-2

Meta-analysis confirms a role for deletion in FCGR3B in autoimmune phenotypes

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2FS13075-015-0609-2

Population Heterogeneity in the Genetic Control of Serum Urate

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2FS13075-015-0609-2

Association between gout and polymorphisms in GCKR in male Han Chinese

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25889045

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Mechanisms of inflammation in gout

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25889045

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1186/S13075-015-0609-2

1 reference

Dimensions Publication ID

7 August 2017

0 references

1 reference

7 August 2017

1 reference