Growth factor receptors as therapeutic targets: strategies to inhibit the insulin-like growth factor I receptor (Q35551142)

8 August 2017

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title

Growth factor receptors as therapeutic targets: strategies to inhibit the insulin-like growth factor I receptor (English)

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8 August 2017

Eva Surmacz

1

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8 August 2017

language of work or name

English

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publication date

1 September 2003

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8 August 2017

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8 August 2017

volume

22

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8 August 2017

issue

42

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8 August 2017

page(s)

6589-6597

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Structure and function of the type 1 insulin-like growth factor receptor.

8 August 2017

cites work

1 reference

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Results of a pilot study involving the use of an antisense oligodeoxynucleotide directed against the insulin-like growth factor type I receptor in malignant astrocytomas

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Blockade of the type I somatomedin receptor inhibits growth of human breast cancer cells in athymic mice

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Antisense RNA to the type I insulin-like growth factor receptor suppresses tumor growth and prevents invasion by rat prostate cancer cells in vivo

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Mutant IGF-I Receptors as Dominant Negatives for Growth and Transformation

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Structural biology of insulin and IGF1 receptors: implications for drug design

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Structure and autoregulation of the insulin-like growth factor 1 receptor kinase

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The activated insulin-like growth factor I receptor induces depolarization in breast epithelial cells characterized by actin filament disassembly and tyrosine dephosphorylation of FAK, Cas, and paxillin.

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The development and clinical use of trastuzumab (Herceptin).

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The ErbB receptors and their role in cancer progression.

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Insulin-like growth factor-I receptor signaling and resistance to trastuzumab (Herceptin).

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Role of the IGF-I receptor in the regulation of cell-cell adhesion: implications in cancer development and progression

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SHC-alpha5beta1 integrin interactions regulate breast cancer cell adhesion and motility

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Inhibition of endosomal insulin-like growth factor-I processing by cysteine proteinase inhibitors blocks receptor-mediated functions

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Dominant negative inhibition of tumorigenesis in vivo by human insulin-like growth factor I receptor mutant

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Suppression of insulin-like growth factor type I receptor by a triple-helix strategy inhibits IGF-I transcription and tumorigenic potential of rat C6 glioblastoma cells

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Dissociation between resistance to apoptosis and the transformed phenotype in IGF-I receptor signaling.

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The IGF system and breast cancer

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Antisense-mediated reduction in insulin-like growth factor-I receptor expression suppresses the malignant phenotype of a human alveolar rhabdomyosarcoma

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Function of the IGF-I receptor in breast cancer

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Dissociation of mitogenesis and transforming activity by C-terminal truncation of the insulin-like growth factor-I receptor

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The IRS-signalling system: a network of docking proteins that mediate insulin action

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Mechanism of STAT3 activation by insulin-like growth factor I receptor

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Stat3 plays an important role in oncogenic Ros- and insulin-like growth factor I receptor-induced anchorage-independent growth

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Effects of genetic blockade of the insulin-like growth factor receptor in human colon cancer cell lines

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7 January 2021

Interference of the IGF system as a strategy to inhibit breast cancer growth

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7 January 2021

ErbB-targeted therapeutic approaches in human cancer

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7 January 2021

Oncogenes and the strategy of growth factors

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7 January 2021

Controlling IGF-receptor function: a possible strategy for tumor therapy

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7 January 2021

The price of independence

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7 January 2021

Substrate competitive inhibitors of IGF-1 receptor kinase

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7 January 2021

The efficacy of small interfering RNAs targeted to the type 1 insulin-like growth factor receptor (IGF1R) is influenced by secondary structure in the IGF1R transcript

1 reference

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7 January 2021

PKB binding proteins. Getting in on the Akt.

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7 January 2021

Cooperative regulation of the invasive and metastatic phenotypes by different domains of the type I insulin-like growth factor receptor beta subunit

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7 January 2021

Inhibition of the type I insulin-like growth factor receptor expression and signaling: novel strategies for antimetastatic therapy

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7 January 2021

Treatment of human breast cancer cells with antisense RNA to the type I insulin-like growth factor receptor inhibits cell growth, suppresses tumorigenesis, alters the metastatic potential, and prolongs survival in vivo.

1 reference

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7 January 2021

Effects of insulin-like growth factors (IGFs) and IGF receptor antibodies on the proliferation of human breast cancer cells

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7 January 2021

Insulin-like growth factors and prostate cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206772

7 January 2021

The roles of integrins and extracellular matrix proteins in the insulin-like growth factor I-stimulated chemotaxis of human breast cancer cells

1 reference

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7 January 2021

IGF-1 in gynaecology and obstetrics: update 2002.

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7 January 2021

Imatinib and chronic myeloid leukemia: validating the promise of molecularly targeted therapy

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7 January 2021

Mechanism of action of erbB tyrosine kinase inhibitors

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7 January 2021

Insulin, insulin-like growth factors and colon cancer: a review of the evidence

1 reference

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7 January 2021

The role of insulin-like growth factor-II in cancer growth and progression evidenced by the use of ribozymes and prostate cancer progression models

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7 January 2021

Imatinib mesylate (Gleevec, Glivec): a new therapy for chronic myeloid leukemia and other malignancies.

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7 January 2021

Inhibition of protein kinase B/Akt. implications for cancer therapy

1 reference

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7 January 2021

Interaction of the monoclonal antibodies alpha IR-1 and alpha IR-3 with insulin and somatomedin-C receptors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206772

7 January 2021

Expression of a kinase-deficient IGF-I-R suppresses tumorigenicity of rhabdomyosarcoma cells constitutively expressing a wild type IGF-I-R

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206772

7 January 2021

Overexpression of the human insulinlike growth factor I receptor promotes ligand-dependent neoplastic transformation

1 reference

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7 January 2021

Role of growth factors in pancreatic cancer.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206772

7 January 2021

Recombinant adenoviruses expressing dominant negative insulin-like growth factor-I receptor demonstrate antitumor effects on lung cancer.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206772

7 January 2021

Tyrosine kinases as targets for cancer therapy

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206772

7 January 2021

Two new monoclonal antibodies against the alpha subunit of the human insulin-like growth factor-I receptor

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206772

7 January 2021

Single-chain antibodies against human insulin-like growth factor I receptor: expression, purification, and effect on tumor growth

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206772

7 January 2021

Downregulation of the type 1 insulin-like growth factor receptor in mouse melanoma cells is associated with enhanced radiosensitivity and impaired activation of Atm kinase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206772

7 January 2021

The EGF receptor family as targets for cancer therapy

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206772

7 January 2021

Insulin-like growth factor I-triggered cell migration and invasion are mediated by matrix metalloproteinase-9

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206772

7 January 2021

Antisense phosphorothioate oligodeoxynucleotide down-regulation of the insulin-like growth factor I receptor in ovarian cancer cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206772

7 January 2021

Growth inhibition of MCF-7 breast cancer cells by stable expression of an insulin-like growth factor I receptor antisense ribonucleic acid

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206772

7 January 2021

The protein kinase B/Akt signalling pathway in human malignancy

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206772

7 January 2021

Regulation of survival signals from the insulin-like growth factor-I receptor

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206772

7 January 2021

Identification of domains of the insulin-like growth factor I receptor that are required for protection from apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206772

7 January 2021

Insulin-like growth factor family and combined antisense approach in therapy of lung carcinoma.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206772

7 January 2021

Multiple signaling pathways of the insulin-like growth factor 1 receptor in protection from apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206772

7 January 2021

Insulin-like growth factor physiology and cancer risk

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206772

7 January 2021

Mechanisms of regulation of cell adhesion and motility by insulin receptor substrate-1 in prostate cancer cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206772

7 January 2021

The IGF axis and hepatocarcinogenesis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206772

7 January 2021

Expression of an IGF-I receptor dominant negative mutant induces apoptosis, inhibits tumorigenesis and enhances chemosensitivity in Ewing's sarcoma cells.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206772

7 January 2021

Retroviral expression of a kinase-defective IGF-I receptor suppresses growth and causes apoptosis of CHO and U87 cells in-vivo

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206772

7 January 2021

Identification of insulin receptor substrate 1 (IRS-1) and IRS-2 as signaling intermediates in the alpha6beta4 integrin-dependent activation of phosphoinositide 3-OH kinase and promotion of invasion

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206772

7 January 2021

Smart drugs: tyrosine kinase inhibitors in cancer therapy

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206772

7 January 2021

Phosphoinositide 3-kinase: the key switch mechanism in insulin signalling

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206772

7 January 2021

Association of insulin receptor substrate-1 with integrins

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206772

7 January 2021

IRS proteins and the common path to diabetes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206772

7 January 2021

The insulin-like growth factor system as a treatment target in breast cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206772

7 January 2021

Type 1 insulin-like growth factor regulates MT1-MMP synthesis and tumor invasion via PI 3-kinase/Akt signaling

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206772

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1206772

1 reference

8 August 2017

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