The Jeremiah Metzger Lecture: intelligent design of cancer therapy: trials and tribulations. (Q35778529)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18528508%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

title

The Jeremiah Metzger Lecture: intelligent design of cancer therapy: trials and tribulations (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18528508%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

author name string

James A Fagin

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18528508%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

publication date

1 January 2007

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18528508%20AND%20SRC:MED&resulttype=core&format=json

Transactions of the American Clinical and Climatological Association

8 January 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18528508%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

volume

118

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18528508%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

page(s)

253-261

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18528508%20AND%20SRC:MED&resulttype=core&format=json

The age incidence of chronic myeloid leukemia can be explained by a one-mutation model

8 January 2020

cites work

1 reference

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12 July 2018

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Sorafenib in advanced melanoma: a Phase II randomised discontinuation trial analysis

12 July 2018

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Nilotinib in imatinib-resistant CML and Philadelphia chromosome-positive ALL

12 July 2018

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BRAF mutation predicts sensitivity to MEK inhibition

12 July 2018

1 reference

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Sequence analysis of the protein kinase gene family in human testicular germ-cell tumors of adolescents and adults

12 July 2018

1 reference

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Somatic mutations of the protein kinase gene family in human lung cancer

12 July 2018

1 reference

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The role of B-RAF in melanoma.

12 July 2018

1 reference

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A small molecule-kinase interaction map for clinical kinase inhibitors

12 July 2018

1 reference

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How thyroid tumors start and why it matters: kinase mutants as targets for solid cancer pharmacotherapy

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1863588

EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy

12 July 2018

1 reference

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Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1863588

Specific targeted therapy of chronic myelogenous leukemia with imatinib

12 July 2018

1 reference

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Tyrosine kinases as targets in cancer therapy - successes and failures

12 July 2018

1 reference

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ZD6474, an orally available inhibitor of KDR tyrosine kinase activity, efficiently blocks oncogenic RET kinases.

12 July 2018

1 reference

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Multiple BCR-ABL kinase domain mutations confer polyclonal resistance to the tyrosine kinase inhibitor imatinib (STI571) in chronic phase and blast crisis chronic myeloid leukemia

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1863588

Crystal structures of the kinase domain of c-Abl in complex with the small molecule inhibitors PD173955 and imatinib (STI-571)

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1863588

Induction and apoptotic regression of lung adenocarcinomas by regulation of a K-Ras transgene in the presence and absence of tumor suppressor genes

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1863588

Targeting c-kit mutations in solid tumors: scientific rationale and novel therapeutic options

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1863588

Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1863588

Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1863588

Jeremiah Metzger Lecture. Targeted cancer therapy

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1863588

Reversible tumorigenesis by MYC in hematopoietic lineages

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1863588

Receptor tyrosine kinases as targets for anticancer therapeutics.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1863588

A screen of the complete protein kinase gene family identifies diverse patterns of somatic mutations in human breast cancer.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1863588

High prevalence of BRAF mutations in thyroid cancer: genetic evidence for constitutive activation of the RET/PTC-RAS-BRAF signaling pathway in papillary thyroid carcinoma

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1863588

Mechanisms of aneuploidy in thyroid cancer cell lines and tissues: evidence for mitotic checkpoint dysfunction without mutations in BUB1 and BUBR1.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1863588

BRAF mutations and RET/PTC rearrangements are alternative events in the etiopathogenesis of PTC

25 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18528508

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Alternative mutations of BRAF, RET and NTRK1 are associated with similar but distinct gene expression patterns in papillary thyroid cancer.

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18528508

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18528508%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

PubMed publication ID

18528508

1 reference