Pirfenidone inhibits transforming growth factor-β1-induced fibrogenesis by blocking nuclear translocation of Smads in human retinal pigment epithelial cell line ARPE-19. (Q35919077)

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scientific article published on 21 April 2012

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English	Pirfenidone inhibits transforming growth factor-β1-induced fibrogenesis by blocking nuclear translocation of Smads in human retinal pigment epithelial cell line ARPE-19.	scientific article published on 21 April 2012

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

Pirfenidone inhibits transforming growth factor-β1-induced fibrogenesis by blocking nuclear translocation of Smads in human retinal pigment epithelial cell line ARPE-19. (English)

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

author name string

Kyungsun Choi

1

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

Kihwang Lee

2

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

Seung-Wook Ryu

3

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

Minju Im

4

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

Koung Hoon Kook

5

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

Chulhee Choi

6

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

publication date

21 April 2012

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Europe PubMed Central

PMC publication ID

11 August 2017

Molecular Vision

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

18

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Europe PubMed Central

PMC publication ID

11 August 2017

1010-1020

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

Trichostatin A enhances proliferation and migration of vascular smooth muscle cells by downregulating thioredoxin 1.

1 reference

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TGF-beta-induced epithelial to mesenchymal transition

1 reference

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27 July 2018

Nucleocytoplasmic shuttling of Smad proteins

1 reference

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RhoA/ROCK-mediated switching between Cdc42- and Rac1-dependent protrusion in MTLn3 carcinoma cells

1 reference

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27 July 2018

Rho plays a key role in TGF-beta1-induced cytoskeletal rearrangement in human retinal pigment epithelium

1 reference

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27 July 2018

Pirfenidone inhibits the expression of HSP47 in TGF-beta1-stimulated human lung fibroblasts

1 reference

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Targeting transforming growth factor-beta signaling

1 reference

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Cell size and invasion in TGF-beta-induced epithelial to mesenchymal transition is regulated by activation of the mTOR pathway

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Inhibition of p38MAP kinase suppresses fibrotic reaction of retinal pigment epithelial cells

1 reference

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Double-blind, placebo-controlled trial of pirfenidone in patients with idiopathic pulmonary fibrosis

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Smad3 as a mediator of the fibrotic response

1 reference

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Targeted disruption of TGF-β1/Smad3 signaling protects against renal tubulointerstitial fibrosis induced by unilateral ureteral obstruction

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Pirfenidone effectively reverses experimental liver fibrosis.

1 reference

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Effect of pirfenidone on rat hepatic stellate cell proliferation and collagen production

1 reference

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Effects of pirfenidone on transforming growth factor-beta gene expression at the transcriptional level in bleomycin hamster model of lung fibrosis

1 reference

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Pirfenidone inhibits PDGF isoforms in bleomycin hamster model of lung fibrosis at the translational level.

1 reference

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Pirfenidone improves renal function and fibrosis in the post-obstructed kidney

1 reference

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Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia

1 reference

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Correlation of fibrosis and transforming growth factor-beta type 2 levels in the eye

1 reference

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Antifibrotic effect of Pirfenidone on orbital fibroblasts of patients with thyroid-associated ophthalmopathy by decreasing TIMP-1 and collagen levels.

1 reference

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Epithelial-mesenchymal transitions in development and disease

1 reference

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The basics of epithelial-mesenchymal transition

1 reference

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Fibroblasts derive from hepatocytes in liver fibrosis via epithelial to mesenchymal transition.

1 reference

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24 September 2018

Inhibition of RhoA/Rho-kinase pathway suppresses the expression of type I collagen induced by TGF-beta2 in human retinal pigment epithelial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3339036

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The anti-fibrotic effect of pirfenidone in rat liver fibrosis is mediated by downregulation of procollagen alpha1(I), TIMP-1 and MMP-2.

1 reference

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Transforming growth factor‐β induces expression of vascular endothelial growth factor in human retinal pigment epithelial cells: Involvement of mitogen‐activated protein kinases

1 reference

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Open-label compassionate use one year-treatment with pirfenidone to patients with chronic pulmonary fibrosis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3339036

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Evidence that fibroblasts derive from epithelium during tissue fibrosis

1 reference

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Novel growth factors involved in the pathogenesis of proliferative vitreoretinopathy

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Pirfenidone treatment decreases transforming growth factor-beta1 and matrix proteins and ameliorates fibrosis in chronic cyclosporine nephrotoxicity

1 reference

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Pirfenidone suppresses tumor necrosis factor-alpha, enhances interleukin-10 and protects mice from endotoxic shock

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Proliferative vitreoretinopathy: risk factors and pathobiology

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Pirfenidone reduces in vitro rat renal fibroblast activation and mitogenesis.

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Matrix metalloproteinases: a role in the contraction of vitreo-retinal scar tissue

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Focal adhesion kinase: a regulator of focal adhesion dynamics and cell movement

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Pirfenidone reduces fibronectin synthesis by cultured human retinal pigment epithelial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3339036

24 September 2018

ARPE-19, a human retinal pigment epithelial cell line with differentiated properties

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3339036

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Pirfenidone Slows Renal Function Decline in Patients with Focal Segmental Glomerulosclerosis

1 reference

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TGF-beta1, TGF-beta receptor II and ED-A fibronectin expression in myofibroblast of vitreoretinopathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/22550395

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pirfenidone prevents collagen accumulation in the remnant kidney in rats with partial nephrectomy

1 reference

https://pubmed.ncbi.nlm.nih.gov/22550395

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IL-10 and antibodies to TGF-beta2 and PDGF inhibit RPE-mediated retinal contraction

1 reference

https://pubmed.ncbi.nlm.nih.gov/22550395

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

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