alpha-Galactosylceramide therapy for autoimmune diseases: prospects and obstacles (Q35998799)

11 August 2017

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title

alpha-Galactosylceramide therapy for autoimmune diseases: prospects and obstacles (English)

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11 August 2017

1

Luc Van Kaer

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11 August 2017

publication date

1 January 2005

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Nature Reviews Immunology

11 August 2017

published in

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11 August 2017

volume

5

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11 August 2017

issue

1

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11 August 2017

page(s)

31-42

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The role of different subsets of T regulatory cells in controlling autoimmunity

11 August 2017

cites work

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Regulatory T cells in autoimmmunity*.

21 January 2018

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NKT cells: facts, functions and fallacies.

21 January 2018

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The unconventional lifestyle of NKT cells

21 January 2018

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The regulatory role of Valpha14 NKT cells in innate and acquired immune response.

21 January 2018

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CD1: antigen presentation and T cell function

21 January 2018

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Going both ways: immune regulation via CD1d-dependent NKT cells

21 January 2018

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Mouse CD1-specific NK1 T cells: development, specificity, and function

21 January 2018

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NKT cells: what's in a name?

21 January 2018

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An invariant V alpha 24-J alpha Q/V beta 11 T cell receptor is expressed in all individuals by clonally expanded CD4-8- T cells

21 January 2018

1 reference

Analysis of T cell antigen receptor (TCR) expression by human peripheral blood CD4-8- alpha/beta T cells demonstrates preferential use of several V beta genes and an invariant TCR alpha chain

21 January 2018

1 reference

Identification and simian immunodeficiency virus infection of CD1d-restricted macaque natural killer T cells

21 January 2018

1 reference

NKT cells in the rat: organ-specific distribution of NK T cells expressing distinct V alpha 14 chains

21 January 2018

1 reference

CD1d-restricted and TCR-mediated activation of valpha14 NKT cells by glycosylceramides

21 January 2018

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Murine CD1d-restricted T cell recognition of cellular lipids

21 January 2018

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Mycobacterial phosphatidylinositol mannoside is a natural antigen for CD1d-restricted T cells

21 January 2018

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Cross-presentation of disialoganglioside GD3 to natural killer T cells

21 January 2018

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Defective presentation of the CD1d1-restricted natural Va14Ja18 NKT lymphocyte antigen caused by beta-D-glucosylceramide synthase deficiency

21 January 2018

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A subset of liver NK T cells is activated during Leishmania donovani infection by CD1d-bound lipophosphoglycan

21 January 2018

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Lysosomal glycosphingolipid recognition by NKT cells

21 January 2018

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An invariant T cell receptor alpha chain is used by a unique subset of major histocompatibility complex class I-specific CD4+ and CD4-8- T cells in mice and humans.

21 January 2018

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Tracking the response of natural killer T cells to a glycolipid antigen using CD1d tetramers

21 January 2018

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In vivo identification of glycolipid antigen-specific T cells using fluorescent CD1d tetramers

21 January 2018

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Functionally distinct subsets of CD1d-restricted natural killer T cells revealed by CD1d tetramer staining

21 January 2018

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CD4(-)CD8alphaalpha subset of CD1d-restricted NKT cells controls T cell expansion

21 January 2018

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Constitutive Cytokine mRNAs Mark Natural Killer (NK) and NK T Cells Poised for Rapid Effector Function

21 January 2018

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Relevance of sexual dimorphism to regulatory T cells: estradiol promotes IFN-gamma production by invariant natural killer T cells.

21 January 2018

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Interferon gamma production by natural killer (NK) cells and NK1.1+ T cells upon NKR-P1 cross-linking

21 January 2018

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Antigen-induced tolerance by intrathymic modulation of self-recognizing inhibitory receptors

21 January 2018

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Mouse V alpha 14i natural killer T cells are resistant to cytokine polarization in vivo

21 January 2018

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Autoreactivity by design: innate B and T lymphocytes

21 January 2018

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Germ line deletion of the CD1 locus exacerbates diabetes in the NOD mouse

21 January 2018

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CD1-restricted NK T cells protect nonobese diabetic mice from developing diabetes

21 January 2018

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CD1-dependent regulation of chronic central nervous system inflammation in experimental autoimmune encephalomyelitis.

21 January 2018

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CD1d deficiency exacerbates inflammatory dermatitis in MRL-lpr/lpr mice

21 January 2018

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Overexpression of natural killer T cells protects Valpha14- Jalpha281 transgenic nonobese diabetic mice against diabetes.

21 January 2018

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Cutting edge: V alpha 14-J alpha 281 NKT cells naturally regulate experimental autoimmune encephalomyelitis in nonobese diabetic mice.

21 January 2018

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NKT cells: potential targets for autoimmune disease therapy?

21 January 2018

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Janus-like role of regulatory iNKT cells in autoimmune disease and tumour immunity

21 January 2018

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CD1d-mediated recognition of an alpha-galactosylceramide by natural killer T cells is highly conserved through mammalian evolution

21 January 2018

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CD1d-restricted recognition of synthetic glycolipid antigens by human natural killer T cells

21 January 2018

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The response of natural killer T cells to glycolipid antigens is characterized by surface receptor down-modulation and expansion

21 January 2018

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Down-regulation of the invariant Valpha14 antigen receptor in NKT cells upon activation.

21 January 2018

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Quantitative and qualitative differences in the in vivo response of NKT cells to distinct alpha- and beta-anomeric glycolipids

21 January 2018

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Therapeutic activation of Vα24+Vβ11+ NKT cells in human subjects results in highly coordinated secondary activation of acquired and innate immunity

21 January 2018

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Osteopontin as a mediator of NKT cell function in T cell-mediated liver diseases.

21 January 2018

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The natural killer T (NKT) cell ligand alpha-galactosylceramide demonstrates its immunopotentiating effect by inducing interleukin (IL)-12 production by dendritic cells and IL-12 receptor expression on NKT cells

21 January 2018

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Activation of CD1d-restricted T cells protects NOD mice from developing diabetes by regulating dendritic cell subsets

21 January 2018

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Immunization with alpha-galactosylceramide polarizes CD1-reactive NK T cells towards Th2 cytokine synthesis.

21 January 2018

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Schistosoma mansoni and alpha-galactosylceramide: prophylactic effect of Th1 Immune suppression in a mouse model of Graves' hyperthyroidism

21 January 2018

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Prolonged IFN-gamma-producing NKT response induced with alpha-galactosylceramide-loaded DCs.

21 January 2018

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Another view of T cell antigen recognition: cooperative engagement of glycolipid antigens by Va14Ja18 natural T(iNKT) cell receptor [corrected].

21 January 2018

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The Paradox of Immune Molecular Recognition of α-Galactosylceramide: Low Affinity, Low Specificity for CD1d, High Affinity for αβ TCRs

21 January 2018

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The V alpha 14 NKT cell TCR exhibits high-affinity binding to a glycolipid/CD1d complex.

21 January 2018

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A synthetic glycolipid prevents autoimmune encephalomyelitis by inducing TH2 bias of natural killer T cells

21 January 2018

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Effects of lipid chain lengths in alpha-galactosylceramides on cytokine release by natural killer T cells

21 January 2018

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Superior protection against malaria and melanoma metastases by a C-glycoside analogue of the natural killer T cell ligand alpha-Galactosylceramide

21 January 2018

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Dissociation of NKT stimulation, cytokine induction, and NK activation in vivo by the use of distinct TCR-binding ceramides

21 January 2018

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Immunotherapy with ligands of natural killer T cells

21 January 2018

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The nonobese diabetic mouse as a model of autoimmune diabetes: immune dysregulation gets the NOD.

21 January 2018

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Activation of natural killer T cells potentiates or prevents experimental autoimmune encephalomyelitis

21 January 2018

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Natural killer T cell activation protects mice against experimental autoimmune encephalomyelitis.

21 January 2018

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Suppression of collagen-induced arthritis by natural killer T cell activation with OCH, a sphingosine-truncated analog of alpha-galactosylceramide

21 January 2018

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Activation of natural killer T cells in NZB/W mice induces Th1-type immune responses exacerbating lupus

21 January 2018

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Cytokine regulation of T-cell function: potential for therapeutic intervention

21 January 2018

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IL-4 utilizes an alternative receptor to drive apoptosis of Th1 cells and skews neonatal immunity toward Th2.

21 January 2018

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Functional diversity of helper T lymphocytes

21 January 2018

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Interferon gamma enhances both in vitro and in vivo priming of CD4+ T cells for IL-4 production.

21 January 2018

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Tolerogenic dendritic cells

21 January 2018

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Th1 to Th2 cytokine shifts in nonobese diabetic mice: sometimes an outcome, rather than the cause, of diabetes resistance elicited by immunostimulation.

21 January 2018

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Involvement of decidual Valpha14 NKT cells in abortion

21 January 2018

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Natural killer T cells contribute to airway eosinophilic inflammation induced by ragweed through enhanced IL-4 and eotaxin production

21 January 2018

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CD1d-dependent activation of NKT cells aggravates atherosclerosis.

21 January 2018

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Natural killer T cells accelerate atherogenesis in mice

21 January 2018

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Innate immune recognition

21 January 2018

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Self-reactivity in thymic double-positive cells commits cells to a CD8 alpha alpha lineage with characteristics of innate immune cells

21 January 2018

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Selection of evolutionarily conserved mucosal-associated invariant T cells by MR1

21 January 2018

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Infiltration of the inflamed eye by NKT cells in a rat model of experimental autoimmune uveitis

21 January 2018

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CD1 recognition by mouse NK1+ T lymphocytes

31 March 2020

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CD1d-restricted immunoglobulin G formation to GPI-anchored antigens mediated by NKT cells

31 March 2020

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Requirement for Valpha14 NKT cells in IL-12-mediated rejection of tumors

31 March 2020

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IL-4-producing NK T cells are biased towards IFN-gamma production by IL-12. Influence of the microenvironment on the functional capacities of NK T cells

31 March 2020

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IL-18 enhances IL-4 production by ligand-activated NKT lymphocytes: a pro-Th2 effect of IL-18 exerted through NKT cells

31 March 2020

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Costimulation-dependent modulation of experimental autoimmune encephalomyelitis by ligand stimulation of V alpha 14 NK T cells

31 March 2020

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Differential regulation of Th1 and Th2 functions of NKT cells by CD28 and CD40 costimulatory pathways

31 March 2020

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CD1d and natural T cells: how their properties jump-start the immune system

31 March 2020

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Regulation of immune responses by CD1d-restricted natural killer T cells

31 March 2020

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Early quantitative and functional deficiency of NK1+-like thymocytes in the NOD mouse

31 March 2020

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Association between alphabetaTCR+CD4-CD8- T-cell deficiency and IDDM in NOD/Lt mice

31 March 2020

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Defective IgE production by SJL mice is linked to the absence of CD4+, NK1.1+ T cells that promptly produce interleukin 4

31 March 2020

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Protection against diabetes and improved NK/NKT cell performance in NOD.NK1.1 mice congenic at the NK complex

31 March 2020

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Genetic Control of NKT Cell Numbers Maps to Major Diabetes and Lupus Loci

31 March 2020

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Genetic Dissection of V 14J 18 Natural T Cell Number and Function in Autoimmune-Prone Mice

31 March 2020

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Do NKT cells control autoimmunity?

31 March 2020

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Agelasphins, novel α-galactosylceramides from the marine sponge Agelas mauritianus

31 March 2020

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Structure-activity relationship of alpha-galactosylceramides against B16-bearing mice

31 March 2020

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Rapid Death and Regeneration of NKT Cells in Anti-CD3ε- or IL-12-Treated Mice

31 March 2020

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Selective induction of NK cell proliferation and cytotoxicity by activated NKT cells

31 March 2020

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Glycolipid Antigen Drives Rapid Expansion and Sustained Cytokine Production by NK T Cells

31 March 2020

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alpha-galactosylceramide induces early B-cell activation through IL-4 production by NKT cells

31 March 2020

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The interface between innate and acquired immunity: glycolipid antigen presentation by CD1d-expressing dendritic cells to NKT cells induces the differentiation of antigen-specific cytotoxic T lymphocytes

31 March 2020

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The natural killer T-cell ligand α-galactosylceramide prevents autoimmune diabetes in non-obese diabetic mice

31 March 2020

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Activation of natural killer T cells by alpha-galactosylceramide treatment prevents the onset and recurrence of autoimmune Type 1 diabetes

31 March 2020

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Repeated -Galactosylceramide Administration Results in Expansion of NK T Cells and Alleviates Inflammatory Dermatitis in MRL-lpr/lpr Mice

31 March 2020

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Anti-suppressor effect of cyclophosphamide on the development of spontaneous diabetes in NOD mice

31 March 2020

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Interleukin-4 but not interleukin-10 protects against spontaneous and recurrent type 1 diabetes by activated CD1d-restricted invariant natural killer T-cells.

31 March 2020

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CD1d-restricted T-cell subsets and dendritic cell function in autoimmunity

31 March 2020

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Activation of invariant NKT cells by alphaGalCer administration protects mice from MOG35-55-induced EAE: critical roles for administration route and IFN-gamma

31 March 2020

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Activation of natural killer T cells by alpha-galactosylceramide in the presence of CD1d provides protection against colitis in mice

31 March 2020

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NKT cells inhibit the onset of diabetes by impairing the development of pathogenic T cells specific for pancreatic beta cells

31 March 2020

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Therapeutic manipulation of iNKT cells in autoimmunity: modes of action and potential risks.

31 March 2020

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Activation of hepatic NKT cells and subsequent liver injury following administration of α-galactosylceramide

31 March 2020

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31 March 2020

inferred from DOI database lookup

7 January 2021

based on heuristic

Quantitative and Qualitative Differences in Proatherogenic NKT Cells in Apolipoprotein E–Deficient Mice

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31 March 2020

Identifiers

DOI

10.1038/NRI1531

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11 August 2017

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