DNA strand breaks induced by nuclear hijacking of neuronal NOS as an anti-cancer effect of 2-methoxyestradiol (Q36021044)

11 August 2017

DNA strand breaks induced by nuclear hijacking of neuronal NOS as an anti-cancer effect of 2-methoxyestradiol (English)

1 reference

11 August 2017

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25972363%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

Francesco Cappello

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25972363%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

Maciej Wnuk

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25972363%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

Monika Gorzynik

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25972363%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

Iwona Rzeszutek

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25972363%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

Agnieszka Daca

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25972363%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

Anna Lewińska

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25972363%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

Michał Woźniak

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25972363%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

Alicja Kuban-Jankowska

2

object named as

Alicja Kuban-Jankowska

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25972363%20AND%20SRC:MED&resulttype=core&format=json

Antonella Marino Gammazza

11 June 2020

4

object named as

Antonella Marino Gammazza

1 reference

11 June 2020

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25972363%20AND%20SRC:MED&resulttype=core&format=json

Magdalena Gorska

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25972363%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

language of work or name

English

0 references

publication date

1 June 2015

1 reference

11 August 2017

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25972363%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

volume

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25972363%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

issue

17

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25972363%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

page(s)

15449-15463

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25972363%20AND%20SRC:MED&resulttype=core&format=json

describes a project that uses

11 June 2020

ImageQuant

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4558163/fullTextXML

inferred from PubMed Central ID database lookup

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4558163/fullTextXML

inferred from PubMed Central ID database lookup

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2 October 2017

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2-methoxyestradiol induces mitotic arrest, apoptosis, and synergistic cytotoxicity with arsenic trioxide in human urothelial carcinoma cells

2 October 2017

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2-Methoxyestradiol in the human corpus luteum throughout the luteal phase and its influence on lutein cell steroidogenesis and angiogenic activity

2 October 2017

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DNA damage induced by nitric oxide during ionizing radiation is enhanced at replication

2 October 2017

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Evaluation of the Combined Effect of 2ME2 and (60)Co on the Inducement of DNA Damage by IUdR in a Spheroid Model of the U87MG Glioblastoma Cancer Cell Line Using Alkaline Comet Assay

2 October 2017

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Genome-wide analyses on high-grade osteosarcoma: making sense of a genomically most unstable tumor.

2 October 2017

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Chronic inflammation as a promotor of mutagenesis in essential thrombocythemia, polycythemia vera and myelofibrosis. A human inflammation model for cancer development?

2 October 2017

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Regulation of interferon pathway in 2-methoxyestradiol-treated osteosarcoma cells

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Taxol alleviates 2-methoxyestradiol-induced endothelial permeability

2 October 2017

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2 October 2017

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2 October 2017

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2-Methoxyestradiol inhibits progesterone-dependent tissue factor expression and activity in breast cancer cells

2 October 2017

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2-methoxyestradiol analogue ENMD-1198 reduces breast cancer-induced osteolysis and tumor burden both in vitro and in vivo

2 October 2017

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2 October 2017

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2 October 2017

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2 October 2017

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2-Methoxyestradiol blocks cell-cycle progression at the G&lt;sub&gt;2&lt;/sub&gt;/M phase and induces apoptosis in human acute T lymphoblastic leukemia CEM cells

2 October 2017

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A phase II study of 2-methoxyestradiol (2ME2) NanoCrystal® dispersion (NCD) in patients with taxane-refractory, metastatic castrate-resistant prostate cancer (CRPC).

2 October 2017

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Subcellular and cellular locations of nitric oxide synthase isoforms as determinants of health and disease

2 October 2017

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A phase I dose-escalation, safety and pharmacokinetic study of the 2-methoxyestradiol analog ENMD-1198 administered orally to patients with advanced cancer

2 October 2017

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Neuronal nitric oxide synthase: structure, subcellular localization, regulation, and clinical implications

2 October 2017

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Mechanisms of 2-methoxyestradiol-induced apoptosis and G2/M cell-cycle arrest of nasopharyngeal carcinoma cells.

2 October 2017

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Inflammation: gearing the journey to cancer

2 October 2017

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2 October 2017

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Deficiency in catechol-O-methyltransferase and 2-methoxyoestradiol is associated with pre-eclampsia

2 October 2017

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2-methoxyestradiol-induced cell death in osteosarcoma cells is preceded by cell cycle arrest

2 October 2017

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Enhanced radiation-induced cytotoxic effect by 2-ME in glioma cells is mediated by induction of cell cycle arrest and DNA damage via activation of ATM pathways

2 October 2017

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2-Methoxyestradiol suppresses osteolytic breast cancer tumor progression in vivo

2 October 2017

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2-Methoxyestradiol--a unique blend of activities generating a new class of anti-tumour/anti-inflammatory agents

2 October 2017

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Chemosensitization of cancer in vitro and in vivo by nitric oxide signaling

2 October 2017

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2-methoxyestradiol, an endogenous mammalian metabolite, radiosensitizes colon carcinoma cells through c-Jun NH2-terminal kinase activation

2 October 2017

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Reactive oxygen species in cancer cells: live by the sword, die by the sword.

2 October 2017

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Physiologic levels of 2-methoxyestradiol interfere with nongenomic signaling of 17beta-estradiol in human breast cancer cells

2 October 2017

1 reference

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Micromolar concentrations of 2-methoxyestradiol kill glioma cells by an apoptotic mechanism, without destroying their microtubule cytoskeleton

2 October 2017

1 reference

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2-Methoxyestradiol-induced apoptosis in human leukemia cells proceeds through a reactive oxygen species and Akt-dependent process.

2 October 2017

1 reference

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Induction of apoptosis or necrosis in human endometrial carcinoma cells by 2-methoxyestradiol.

2 October 2017

1 reference

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Nitric oxide reverts the resistance to doxorubicin in human colon cancer cells by inhibiting the drug efflux.

2 October 2017

1 reference

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Oxidative DNA damage: mechanisms, mutation, and disease

2 October 2017

1 reference

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HUMN project: detailed description of the scoring criteria for the cytokinesis-block micronucleus assay using isolated human lymphocyte cultures.

2 October 2017

1 reference

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Dual effect of 2-methoxyestradiol on cell cycle events in human osteosarcoma 143B cells.

2 October 2017

1 reference

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2-Methoxyestradiol inhibits proliferation and induces apoptosis independently of estrogen receptors alpha and beta

2 October 2017

1 reference

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The physiological estrogen metabolite 2-methoxyestradiol reduces tumor growth and induces apoptosis in human solid tumors

2 October 2017

1 reference

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Nitric oxide synthases: structure, function and inhibition

2 October 2017

1 reference

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The in vitro micronucleus technique

2 October 2017

1 reference

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Origin of superoxide production by endothelial nitric oxide synthase

2 October 2017

1 reference

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Characterization of bovine endothelial nitric oxide synthase as a homodimer with down-regulated uncoupled NADPH oxidase activity: tetrahydrobiopterin binding kinetics and role of haem in dimerization

2 October 2017

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2 October 2017

No .NO from NO synthase

1 reference

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Damage to DNA by reactive oxygen and nitrogen species: role in inflammatory disease and progression to cancer

2 October 2017

1 reference

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Multicellular Resistance: A New Paradigm to Explain Aspects of Acquired Drug Resistance of Solid Tumors

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4558163

Formation of free nitric oxide from l-arginine by nitric oxide synthase: direct enhancement of generation by superoxide dismutase.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4558163

Nuclear recruitment of neuronal nitric-oxide synthase by α-syntrophin is crucial for the induction of mitochondrial biogenesis

2 October 2017

1 reference

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Detection and imaging of nitric oxide with novel fluorescent indicators: diaminofluoresceins.

11 July 2018

1 reference

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A discussion of mechanisms of NO genotoxicity: implication of inhibition of DNA repair proteins

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4558163

2-Methoxyestradiol, an endogenous estrogen metabolite, induces apoptosis in endothelial cells and inhibits angiogenesis: possible role for stress-activated protein kinase signaling pathway and Fas expression.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4558163

Identification of the domains of neuronal nitric oxide synthase by limited proteolysis

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4558163

Pharmacological effects of 2- and 4-methyloestradiol as a probe to test the biological importance of 2- and 4-hydroxylation of oestrogens (catecholoestrogen-formation)

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4558163

Measurement of intracellular nitric oxide (NO) production in shrimp haemocytes by flow cytometry

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4558163

Modification of DNA damage mechanisms by nitric oxide during ionizing radiation

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4558163

2ME and 2OHE2 exhibit growth inhibitory effects and cell cycle arrest at G2/M in RL95-2 human endometrial cancer cells through activation of p53 and Chk1.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4558163

Activity of 2 methoxyestradiol (Panzem NCD) in advanced, platinum-resistant ovarian cancer and primary peritoneal carcinomatosis: a Hoosier Oncology Group trial.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4558163

Novel therapy with 2-methoxyestradiol for the treatment of relapsed and plateau phase multiple myeloma

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4558163

Phase I clinical trial of oral 2-methoxyestradiol, an antiangiogenic and apoptotic agent, in patients with solid tumors

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4558163

A phase II multicenter, randomized, double-blind, safety trial assessing the pharmacokinetics, pharmacodynamics, and efficacy of oral 2-methoxyestradiol capsules in hormone-refractory prostate cancer

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4558163

2-methoxyestradiol induces caspase-independent, mitochondria-centered apoptosis in DS-sarcoma cells

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4558163

Hypoxia induced resistance to doxorubicin in prostate cancer cells is inhibited by low concentrations of glyceryl trinitrate

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4558163

2-Methoxyestradiol induces apoptosis in Ewing sarcoma cells through mitochondrial hydrogen peroxide production

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4558163

Nitric oxide donor increases the efficiency of cytostatic therapy and retards the development of drug resistance

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4558163

2-Methoxyestradiol induces mitochondria dependent apoptotic signaling in pancreatic cancer cells

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4558163

Microtubule-active agents modify nitric oxide production in pulmonary artery endothelial cells

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4558163

2-methoxyestradiol induces interferon gene expression and apoptosis in osteosarcoma cells

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4558163

Formation of peroxynitrite from reaction of nitroxyl anion with molecular oxygen

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4558163

Evidence for a bidomain structure of constitutive cerebellar nitric oxide synthase

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4558163

Tissue distribution of 2-methoxyestradiol nanosuspension in rats and its antitumor activity in C57BL/6 mice bearing lewis lung carcinoma

23 September 2018

1 reference

12 December 2020

Nitric oxide signaling regulates mitochondrial number and function

1 reference

12 December 2020

Concentrations of 2-methoxyoestrogens in human serum measured by a heterologous immunoassay with an 125I-labelled ligand

1 reference

12 December 2020

Localization of Nitric Oxide Synthase in Human Skeletal Muscle

1 reference

12 December 2020

Identifiers

DOI

10.18632/ONCOTARGET.3913

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25972363%20AND%20SRC:MED&resulttype=core&format=json

release_u55ox4pxkrepjjtyiuspwrckya

11 June 2020

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/u55ox4pxkrepjjtyiuspwrckya

24 November 2022

mapped directly with Wikidata item

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25972363%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

PubMed publication ID

25972363

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25972363%20AND%20SRC:MED&resulttype=core&format=json