Coenzyme A-free activity, crystal structure, and rational engineering of a promiscuous β-ketoacyl thiolase from Ralstonia eutropha. (Q36174841)

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28 February 2020

title

Coenzyme A-free activity, crystal structure, and rational engineering of a promiscuous β-ketoacyl thiolase from Ralstonia eutropha (English)

1 reference

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28 February 2020

Ralstonia eutropha

1 reference

1

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28 February 2020

Jessica L Meinke

series ordinal

2

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28 February 2020

author name string

Adrian T Keatinge-Clay

series ordinal

3

1 reference

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28 February 2020

publication date

1 November 2015

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Journal of Molecular Catalysis B: Enzymatic

28 February 2020

published in

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28 February 2020

volume

121

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28 February 2020

page(s)

113-121

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Processing of X-ray diffraction data collected in oscillation mode

28 February 2020

cites work

1 reference

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FadA5 a thiolase from Mycobacterium tuberculosis: a steroid-binding pocket reveals the potential for drug development against tuberculosis

1 October 2017

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Crystal structure and biochemical characterization of PhaA from Ralstonia eutropha, a polyhydroxyalkanoate-producing bacterium

1 October 2017

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A Close Look at a Ketosynthase from a Trans-Acyltransferase Modular Polyketide Synthase

1 October 2017

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Crystal structure and biochemical characterization of beta-keto thiolase B from polyhydroxyalkanoate-producing bacterium Ralstonia eutropha H16

1 October 2017

1 reference

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Fast, scalable generation of high-quality protein multiple sequence alignments using Clustal Omega

1 October 2017

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Overview of the CCP4 suite and current developments

1 October 2017

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Peroxisomal plant 3-ketoacyl-CoA thiolase structure and activity are regulated by a sensitive redox switch.

1 October 2017

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PHENIX: a comprehensive Python-based system for macromolecular structure solution

1 October 2017

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MolProbity: all-atom structure validation for macromolecular crystallography

1 October 2017

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Uses and production of chiral 3-hydroxy-gamma-butyrolactones and structurally related chemicals

1 October 2017

1 reference

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Improved prediction of protein side-chain conformations with SCWRL4

1 October 2017

1 reference

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1 October 2017

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Bacterial synthesis of biodegradable polyhydroxyalkanoates

1 October 2017

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Polyhydroxyalkanoates in Gram-positive bacteria: insights from the genera Bacillus and Streptomyces

1 October 2017

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The thiolase superfamily: condensing enzymes with diverse reaction specificities

1 October 2017

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FFAS03: a server for profile--profile sequence alignments

1 October 2017

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Coot: model-building tools for molecular graphics

1 October 2017

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Refinement of macromolecular structures by the maximum-likelihood method

1 October 2017

1 reference

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An antibiotic factory caught in action

1 October 2017

1 reference

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Production of polyhydroxyalkanoates by mixed culture: recent trends and biotechnological importance.

1 October 2017

1 reference

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The catalytic cycle of biosynthetic thiolase: a conformational journey of an acetyl group through four binding modes and two oxyanion holes

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4610036

Structures of beta-ketoacyl-acyl carrier protein synthase I complexed with fatty acids elucidate its catalytic machinery

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4610036

Crystallographic analysis of the reaction pathway of Zoogloea ramigera biosynthetic thiolase

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4610036

A biosynthetic thiolase in complex with a reaction intermediate: the crystal structure provides new insights into the catalytic mechanism

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4610036

Protein crystals and their evil twins

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4610036

Multiple beta-ketothiolases mediate poly(beta-hydroxyalkanoate) copolymer synthesis in Ralstonia eutropha

1 October 2017

1 reference

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The 1.8 A crystal structure of the dimeric peroxisomal 3-ketoacyl-CoA thiolase of Saccharomyces cerevisiae: implications for substrate binding and reaction mechanism

1 October 2017

1 reference

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Mechanistic studies on beta-ketoacyl thiolase from Zoogloea ramigera: identification of the active-site nucleophile as Cys89, its mutation to Ser89, and kinetic and thermodynamic characterization of wild-type and mutant enzymes

1 October 2017

1 reference

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Occurrence, metabolism, metabolic role, and industrial uses of bacterial polyhydroxyalkanoates

1 October 2017

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A platform pathway for production of 3-hydroxyacids provides a biosynthetic route to 3-hydroxy-γ-butyrolactone.

1 October 2017

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A statistic for local intensity differences: robustness to anisotropy and pseudo-centering and utility for detecting twinning.

23 September 2018

1 reference

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Employing modular polyketide synthase ketoreductases as biocatalysts in the preparative chemoenzymatic syntheses of diketide chiral building blocks

23 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26494979

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Biosynthetic thiolase from zoogloea ramigera. I. Preliminary characterization and analysis of proton transfer reaction

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26494979

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.MOLCATB.2015.08.007

1 reference

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28 February 2020

1 reference

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28 February 2020

1 reference