p300 exerts an epigenetic role in chronic neuropathic pain through its acetyltransferase activity in rats following chronic constriction injury (CCI). (Q36571914)

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scientific article published on 23 November 2012

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English	p300 exerts an epigenetic role in chronic neuropathic pain through its acetyltransferase activity in rats following chronic constriction injury (CCI).	scientific article published on 23 November 2012

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scholarly article

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18 February 2020

p300 exerts an epigenetic role in chronic neuropathic pain through its acetyltransferase activity in rats following chronic constriction injury (CCI) (English)

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18 February 2020

neuropathic pain

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chronic neuropathic pain

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Changsheng Huang

2

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18 February 2020

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Xiao-Yan Zhu

1

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18 February 2020

Qian Li

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18 February 2020

Rui-Min Chang

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18 February 2020

Zong-Bing Song

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18 February 2020

Wang-Yuan Zou

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18 February 2020

Qu-Lian Guo

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18 February 2020

publication date

23 November 2012

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18 February 2020

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18 February 2020

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18 February 2020

84

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18 February 2020

Chronic pain: emerging evidence for the involvement of epigenetics

1 reference

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Epigenetic suppression of GAD65 expression mediates persistent pain

1 reference

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30 September 2017

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Unphosphorylated STAT6 contributes to constitutive cyclooxygenase-2 expression in human non-small cell lung cancer

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Histone acetyltransferase p300 modulates gene expression in an epigenetic manner at high blood alcohol levels

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1 reference

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1 reference

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Histone acetylation and transcriptional regulatory mechanisms

1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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GW406381, a novel COX-2 inhibitor, attenuates spontaneous ectopic discharge in sural nerves of rats following chronic constriction injury

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18 February 2020

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18 February 2020

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