Understanding how the V(D)J recombinase catalyzes transesterification: distinctions between DNA cleavage and transposition (Q36676457)

15 August 2017

Understanding how the V(D)J recombinase catalyzes transesterification: distinctions between DNA cleavage and transposition (English)

1 reference

15 August 2017

Catherine P Lu

1

1 reference

15 August 2017

Jennifer E Posey

series ordinal

2

1 reference

15 August 2017

David B Roth

series ordinal

3

1 reference

15 August 2017

language of work or name

English

0 references

publication date

29 March 2008

1 reference

15 August 2017

10

1 reference

inferred from page(s)

published in

Nucleic Acids Research

1 reference

15 August 2017

36

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15 August 2017

9

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15 August 2017

2864-2873

1 reference

describes a project that uses

15 August 2017

ImageQuant

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2396405/fullTextXML

inferred from PubMed Central ID database lookup

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A plant homeodomain in RAG-2 that binds Hypermethylated lysine 4 of histone H3 is necessary for efficient antigen-receptor-gene rearrangement

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Chromosomal reinsertion of broken RSS ends during T cell development

30 September 2017

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Requirements for DNA hairpin formation by RAG1/2

30 September 2017

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Target DNA structure plays a critical role in RAG transposition

30 September 2017

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Genomic instability due to V(D)J recombination-associated transposition.

30 September 2017

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Mobilization of RAG-generated signal ends by transposition and insertion in vivo

30 September 2017

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A direct interaction between the RAG2 C terminus and the core histones is required for efficient V(D)J recombination

30 September 2017

1 reference

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DNA mismatches and GC-rich motifs target transposition by the RAG1/RAG2 transposase

30 September 2017

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Restraining the V(D)J recombinase

30 September 2017

1 reference

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The C-terminal portion of RAG2 protects against transposition in vitro

30 September 2017

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Regulation of RAG1/RAG2-mediated transposition by GTP and the C-terminal region of RAG2

30 September 2017

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In vivo transposition mediated by V(D)J recombinase in human T lymphocytes

30 September 2017

1 reference

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Deletion of the RAG2 C terminus leads to impaired lymphoid development in mice

30 September 2017

1 reference

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V(D)J recombination: RAG proteins, repair factors, and regulation

30 September 2017

1 reference

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Mutational analysis of all conserved basic amino acids in RAG-1 reveals catalytic, step arrest, and joining-deficient mutants in the V(D)J recombinase

30 September 2017

1 reference

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Targeted transposition by the V(D)J recombinase

30 September 2017

1 reference

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Increased accumulation of hybrid V(D)J joins in cells expressing truncated versus full-length RAGs.

30 September 2017

1 reference

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Identification of basic residues in RAG2 critical for DNA binding by the RAG1-RAG2 complex

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2396405

Rag-1 mutations associated with B-cell-negative scid dissociate the nicking and transesterification steps of V(D)J recombination

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2396405

Conditional RAG-1 mutants block the hairpin formation step of V(D)J recombination

30 September 2017

1 reference

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Differential requirements for cis and trans V(D)J cleavage: effects of substrate length

30 September 2017

1 reference

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Three-dimensional structure of the Tn5 synaptic complex transposition intermediate

30 September 2017

1 reference

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Mutations of acidic residues in RAG1 define the active site of the V(D)J recombinase

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2396405

Mutational analysis of RAG1 and RAG2 identifies three catalytic amino acids in RAG1 critical for both cleavage steps of V(D)J recombination

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2396405

Detection of RAG protein-V(D)J recombination signal interactions near the site of DNA cleavage by UV cross-linking

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2396405

RAG-2 promotes heptamer occupancy by RAG-1 in the assembly of a V(D)J initiation complex

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2396405

Transposition mediated by RAG1 and RAG2 and its implications for the evolution of the immune system

30 September 2017

1 reference

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Dual role of RAG2 in V(D)J recombination: catalysis and regulation of ordered Ig gene assembly

30 September 2017

1 reference

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Distinct roles of RAG1 and RAG2 in binding the V(D)J recombination signal sequences

30 September 2017

1 reference

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A stable RAG1-RAG2-DNA complex that is active in V(D)J cleavage

30 September 2017

1 reference

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DNA sequence and structure requirements for cleavage of V(D)J recombination signal sequences

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2396405

Distinct DNA sequence and structure requirements for the two steps of V(D)J recombination signal cleavage

30 September 2017

1 reference

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Genetic evidence that the RAG1 protein directly participates in V(D)J recombination through substrate recognition

30 September 2017

1 reference

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Hairpin opening by single-strand-specific nucleases

30 September 2017

1 reference

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On the deletion of inverted repeated DNA in Escherichia coli: effects of length, thermal stability, and cruciform formation in vivo

30 September 2017

1 reference

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Separation-of-function mutants reveal critical roles for RAG2 in both the cleavage and joining steps of V(D)J recombination

30 September 2017

1 reference

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DNA transposition by the RAG1 and RAG2 proteins: a possible source of oncogenic translocations

28 June 2018

1 reference

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Localization, interaction, and RNA binding properties of the V(D)J recombination-activating proteins RAG1 and RAG2.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2396405

The IS4 family of insertion sequences: evidence for a conserved transposase motif

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2396405

Base-flipping dynamics in a DNA hairpin processing reaction

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2396405

Amino acid residues in Rag1 crucial for DNA hairpin formation.

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2396405

Transposition of hAT elements links transposable elements and V(D)J recombination.

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2396405

RAG proteins shepherd double-strand breaks to a specific pathway, suppressing error-prone repair, but RAG nicking initiates homologous recombination

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2396405

V(D)J recombination and RAG-mediated transposition in yeast.

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2396405

Tn5 transposase active site mutants

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2396405

Identification of two catalytic residues in RAG1 that define a single active site within the RAG1/RAG2 protein complex.

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2396405

Cleavage at a V(D)J recombination signal requires only RAG1 and RAG2 proteins and occurs in two steps

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2396405

RAG-1 mutations that affect the target specificity of V(D)j recombination: a possible direct role of RAG-1 in site recognition.

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2396405

Rag mutations reveal robust alternative end joining

5 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18375979

12 December 2020

inferred from PubMed ID database lookup

Structure of branched DNA molecules: gel retardation and atomic force microscopy studies

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18375979

12 December 2020

inferred from PubMed ID database lookup

Single active site catalysis of the successive phosphoryl transfer steps by DNA transposases: insights from phosphorothioate stereoselectivity

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18375979

12 December 2020

inferred from PubMed ID database lookup

Identifiers

1 reference

https://api.fatcat.wiki/v0/release/tjc4b5fcgjfgjf733vwtf7qtxa

30 July 2022

release_tjc4b5fcgjfgjf733vwtf7qtxa

Fatcat ID

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Fatcat

https://api.fatcat.wiki/v0/release/tjc4b5fcgjfgjf733vwtf7qtxa

30 July 2022

https://api.fatcat.wiki/v0/release/tjc4b5fcgjfgjf733vwtf7qtxa

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30 July 2022

https://api.fatcat.wiki/v0/release/tjc4b5fcgjfgjf733vwtf7qtxa

PubMed publication ID

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30 July 2022