Neurogenin3 activation is not sufficient to direct duct-to-beta cell transdifferentiation in the adult pancreas. (Q37132108)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23867457%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

title

Neurogenin3 activation is not sufficient to direct duct-to-beta cell transdifferentiation in the adult pancreas (English)

1 reference

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5 March 2020

0 references

1

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5 March 2020

Krishna Prasadan

4

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5 March 2020

Yousef El-Gohary

5

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5 March 2020

author name string

Ping Guo

2

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5 March 2020

Chiyo Shiota

3

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5 March 2020

John Wiersch

6

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5 March 2020

Iljana Gaffar

7

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5 March 2020

George K Gittes

8

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5 March 2020

language of work or name

English

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publication date

18 July 2013

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Journal of Biological Chemistry

5 March 2020

published in

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5 March 2020

volume

288

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5 March 2020

issue

35

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5 March 2020

page(s)

25297-25308

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No evidence for β cell neogenesis in murine adult pancreas

5 March 2020

cites work

1 reference

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The role of aging upon β cell turnover

14 September 2017

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14 September 2017

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14 September 2017

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β-Cells are not generated in pancreatic duct ligation-induced injury in adult mice

14 September 2017

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14 September 2017

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TGFβ receptor signaling is essential for inflammation-induced but not β-cell workload-induced β-cell proliferation

14 September 2017

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14 September 2017

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Beta cell count instead of beta cell mass to assess and localize growth in beta cell population following pancreatic duct ligation in mice

14 September 2017

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Local in vivo GSK3β knockdown promotes pancreatic β cell and acinar cell regeneration in 90% pancreatectomized rat

14 September 2017

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14 September 2017

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Pancreatic beta cells in very old mice retain capacity for compensatory proliferation

14 September 2017

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Tamoxifen-Induced Cre-loxP Recombination Is Prolonged in Pancreatic Islets of Adult Mice

14 September 2017

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Streptozotocin-induced expression of Ngn3 and Pax4 in neonatal rat pancreatic α-cells

14 September 2017

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MafA and MafB activity in pancreatic β cells

14 September 2017

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Progenitor cell domains in the developing and adult pancreas

14 September 2017

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Tamoxifen-independent recombination in the RIP-CreER mouse

14 September 2017

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FoxOs function synergistically to promote glucose production

14 September 2017

1 reference

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Adult pancreatic acinar cells give rise to ducts but not endocrine cells in response to growth factor signaling

14 September 2017

1 reference

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Sustained Neurog3 expression in hormone-expressing islet cells is required for endocrine maturation and function

14 September 2017

1 reference

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Adaptive beta-cell proliferation is severely restricted with advanced age.

14 September 2017

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Minireview: Meeting the demand for insulin: molecular mechanisms of adaptive postnatal beta-cell mass expansion

14 September 2017

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Generation and regeneration of cells of the liver and pancreas

14 September 2017

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Carbonic anhydrase II-positive pancreatic cells are progenitors for both endocrine and exocrine pancreas after birth

14 September 2017

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Developmental biology of the pancreas: a comprehensive review

14 September 2017

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Beta cells within single human islets originate from multiple progenitors

14 September 2017

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Beta-cell proliferation, but not neogenesis, following 60% partial pancreatectomy is impaired in the absence of FoxM1.

14 September 2017

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Beta-cell replication is the primary mechanism subserving the postnatal expansion of beta-cell mass in humans

14 September 2017

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Beta cells can be generated from endogenous progenitors in injured adult mouse pancreas

14 September 2017

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Notch signalling suppresses apoptosis in adult human and mouse pancreatic islet cells

14 September 2017

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An illustrated review of early pancreas development in the mouse.

14 September 2017

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14 September 2017

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New sources of pancreatic beta-cells

14 September 2017

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Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation

14 September 2017

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Gene expression cascades in pancreatic development

14 September 2017

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The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic beta cell growth

14 September 2017

1 reference

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Neurogenin3 is differentially required for endocrine cell fate specification in the intestinal and gastric epithelium

14 September 2017

1 reference

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A view on beta cell transplantation in diabetes.

14 September 2017

1 reference

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Direct evidence for the pancreatic lineage: NGN3+ cells are islet progenitors and are distinct from duct progenitors

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3757194

The forkhead transcription factor Foxo1 (Fkhr) confers insulin sensitivity onto glucose-6-phosphatase expression

14 September 2017

1 reference

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Independent development of pancreatic alpha- and beta-cells from neurogenin3-expressing precursors: a role for the notch pathway in repression of premature differentiation

14 September 2017

1 reference

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Robust acinar cell transgene expression of CreErT via BAC recombineering

14 September 2017

1 reference

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Beta cell replication is the primary mechanism for maintaining postnatal beta cell mass.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3757194

Expression of neurogenin3 reveals an islet cell precursor population in the pancreas

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3757194

Sox9+ ductal cells are multipotent progenitors throughout development but do not produce new endocrine cells in the normal or injured adult pancreas.

29 September 2017

1 reference

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Ductal origin hypothesis of pancreatic regeneration under attack

27 June 2018

1 reference

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Recovery from diabetes in mice by beta cell regeneration

27 June 2018

1 reference

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Alterations in neural crest migration by a monoclonal antibody that affects cell adhesion

27 June 2018

1 reference

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Lineage tracing reveals the dynamic contribution of Hes1+ cells to the developing and adult pancreas.

27 June 2018

1 reference

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Continuous cell supply from a Sox9-expressing progenitor zone in adult liver, exocrine pancreas and intestine.

3 September 2018

1 reference

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Pancreatic exocrine duct cells give rise to insulin-producing beta cells during embryogenesis but not after birth

3 September 2018

1 reference

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The long lifespan and low turnover of human islet beta cells estimated by mathematical modelling of lipofuscin accumulation.

3 September 2018

1 reference

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Growth and regeneration of adult beta cells does not involve specialized progenitors.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3757194

Preexisting pancreatic acinar cells contribute to acinar cell, but not islet beta cell, regeneration.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3757194

Lineage tracing evidence for in vitro dedifferentiation but rare proliferation of mouse pancreatic beta-cells.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3757194

Role of the forkhead protein FoxO1 in beta cell compensation to insulin resistance

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3757194

Very slow turnover of beta-cells in aged adult mice

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3757194

Enhanced expression of PDX-1 and Ngn3 by exendin-4 during beta cell regeneration in STZ-treated mice.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3757194

Neurogenin 3-expressing progenitor cells in the gastrointestinal tract differentiate into both endocrine and non-endocrine cell types

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3757194

Apoptosis differently affects lineage tracing of Lgr5 and Bmi1 intestinal stem cell populations

3 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23867457

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1074/JBC.M113.484022

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23867457%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23867457%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

PubMed publication ID

23867457

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23867457%20AND%20SRC:MED&resulttype=core&format=json