The deviant ATP-binding site of the multidrug efflux pump Pdr5 plays an active role in the transport cycle (Q37234052)

19 August 2017

The deviant ATP-binding site of the multidrug efflux pump Pdr5 plays an active role in the transport cycle (English)

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19 August 2017

2

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13 June 2020

author name string

Christopher Furman

1

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13 June 2020

Neeti Ananthaswamy

3

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13 June 2020

Nidhi Arya

4

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13 June 2020

Bridget Kulesh

5

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13 June 2020

Ildiko Kovach

6

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13 June 2020

Suresh V Ambudkar

7

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13 June 2020

John Golin

8

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13 June 2020

language of work or name

English

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publication date

9 September 2013

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Journal of Biological Chemistry

19 August 2017

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13 June 2020

volume

288

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13 June 2020

issue

42

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13 June 2020

page(s)

30420-30431

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The transmission interface of the Saccharomyces cerevisiae multidrug transporter Pdr5: Val-656 located in intracellular loop 2 plays a major role in drug resistance.

13 June 2020

cites work

1 reference

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A conserved interdomain communication pathway of pseudosymmetrically distributed residues affects substrate specificity of the fungal multidrug transporter Cdr1p

6 September 2017

1 reference

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Crystal structure of a heterodimeric ABC transporter in its inward-facing conformation

6 September 2017

1 reference

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An interaction between the Walker A and D-loop motifs is critical to ATP hydrolysis and cooperativity in bacteriophage T4 Rad50

6 September 2017

1 reference

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Glutamine residues in Q-loops of multidrug resistance protein MRP1 contribute to ATP binding via interaction with metal cofactor

6 September 2017

1 reference

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The multidrug transporter Pdr5: a molecular diode?

6 September 2017

1 reference

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Toward understanding the mechanism of action of the yeast multidrug resistance transporter Pdr5p: A molecular modeling study

6 September 2017

1 reference

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Divergent signature motifs of nucleotide binding domains of ABC multidrug transporter, CaCdr1p of pathogenic Candida albicans, are functionally asymmetric and noninterchangeable

6 September 2017

1 reference

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The signaling interface of the yeast multidrug transporter Pdr5 adopts a cis conformation, and there are functional overlap and equivalence of the deviant and canonical Q-loop residues

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3798506

ABC transporters: a riddle wrapped in a mystery inside an enigma

6 September 2017

1 reference

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Mutations define cross-talk between the N-terminal nucleotide-binding domain and transmembrane helix-2 of the yeast multidrug transporter Pdr5: possible conservation of a signaling interface for coupling ATP hydrolysis to drug transport

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3798506

A mutation of the H-loop selectively affects rhodamine transport by the yeast multidrug ABC transporter Pdr5.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3798506

Structure and function of ABC transporters: the ATP switch provides flexible control

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3798506

Normal gating of CFTR requires ATP binding to both nucleotide-binding domains and hydrolysis at the second nucleotide-binding domain

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3798506

Purification and characterization of the N-terminal nucleotide binding domain of an ABC drug transporter of Candida albicans: uncommon cysteine 193 of Walker A is critical for ATP hydrolysis

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3798506

Evaluation of cooperative interactions between substructures of iso-1-cytochrome c using double mutant cycles.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3798506

Antifungal drug resistance

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3798506

Mechanisms of resistance to fungicides in field strains of Botrytis cinerea

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3798506

Investigation of the role of glutamine-471 and glutamine-1114 in the two catalytic sites of P-glycoprotein

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3798506

Double-mutant cycles: a powerful tool for analyzing protein structure and function

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3798506

Mechanisms of resistance to azole antifungal agents in Candida albicans isolates from AIDS patients involve specific multidrug transporters

6 September 2017

1 reference

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ATP binding to the first nucleotide binding domain of multidrug resistance-associated protein plays a regulatory role at low nucleotide concentration, whereas ATP hydrolysis at the second plays a dominant role in ATP-dependent leukotriene C4 transpo

6 September 2017

1 reference

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Functionally Relevant Residues of Cdr1p: A Multidrug ABC Transporter of Human Pathogenic Candida albicans

14 September 2017

1 reference

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Pairwise interactions between neuronal alpha(7) acetylcholine receptors and alpha-conotoxin PnIB.

28 September 2017

1 reference

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Characterization of the E506Q and H537A dysfunctional mutants in the E. coli ABC transporter MsbA.

28 September 2017

1 reference

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CFTR channel opening by ATP-driven tight dimerization of its nucleotide-binding domains

26 June 2018

1 reference

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Complete inhibition of the Pdr5p multidrug efflux pump ATPase activity by its transport substrate clotrimazole suggests that GTP as well as ATP may be used as an energy source

26 June 2018

1 reference

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The role of hydrogen bond acceptor groups in the interaction of substrates with Pdr5p, a major yeast drug transporter

3 September 2018

1 reference

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Heterogeneous mechanisms of azole resistance in Candida albicans clinical isolates from an HIV-infected patient on continuous fluconazole therapy for oropharyngeal candidosis

3 September 2018

1 reference

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ATP binding, not hydrolysis, at the first nucleotide-binding domain of multidrug resistance-associated protein MRP1 enhances ADP.Vi trapping at the second domain

3 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.1074%2FJBC.M113.494682

Effects of the L511P and D512G mutations on the Escherichia coli ABC transporter MsbA

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1074%2FJBC.M113.494682

Subcellular trafficking of the yeast plasma membrane ABC transporter, Pdr5, is impaired by a mutation in the N-terminal nucleotide-binding fold

21 January 2018

1 reference

12 December 2020

Solubilization and characterization of the overexpressed PDR5 multidrug resistance nucleotide triphosphatase of yeast

1 reference

12 December 2020

Role of the D-loops in allosteric control of ATP hydrolysis in an ABC transporter

1 reference

12 December 2020

Anticancer drugs, ionophoric peptides, and steroids as substrates of the yeast multidrug transporter Pdr5p

1 reference

12 December 2020

Identifiers

DOI

10.1074/JBC.M113.494682

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24019526%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

1 reference

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13 June 2020

PubMed publication ID

24019526

1 reference