Improvement of drug-like properties of peptides: the somatostatin paradigm (Q38028559)

27 August 2017

title

Improvement of drug-like properties of peptides: the somatostatin paradigm (English)

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27 August 2017

Oded Ovadia

1

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27 August 2017

Sarit Greenberg

2

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27 August 2017

Burkhardt Laufer

3

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27 August 2017

Chaim Gilon

4

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27 August 2017

Amnon Hoffman

5

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27 August 2017

Horst Kessler

6

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27 August 2017

language of work or name

English

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publication date

3 June 2010

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Expert Opinion on Drug Discovery

27 August 2017

published in

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27 August 2017

volume

5

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27 August 2017

issue

7

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27 August 2017

page(s)

655-671

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The emerging importance of predictive ADME simulation in drug discovery

27 August 2017

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Oral delivery of peptide drugs: barriers and developments.

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Backbone cyclic peptidomimetic melanocortin-4 receptor agonist as a novel orally administrated drug lead for treating obesity

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Opportunities in somatostatin research: biological, chemical and therapeutic aspects

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Somatostatin receptor subtypes: basic pharmacology and tissue distribution.

21 January 2018

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Classification and nomenclature of somatostatin receptors

21 January 2018

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21 January 2018

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Cell specific expression of the sst2A and sst5 somatostatin receptors in the rat anterior pituitary

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Subtype-selective expression of the five somatostatin receptors (hSSTR1-5) in human pancreatic islet cells: a quantitative double-label immunohistochemical analysis

21 January 2018

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Somatostatin analogs for cancer treatment and diagnosis: an overview

21 January 2018

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Mechanisms of antineoplastic action of somatostatin analogs

21 January 2018

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Antiproliferative effect of somatostatin and analogs

21 January 2018

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Future aspects of somatostatin-receptor-mediated therapy

21 January 2018

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Efficacy of long-term lanreotide treatment in patients with acromegaly

21 January 2018

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Synthesis and biological activity of highly potent octapeptide analogs of somatostatin

21 January 2018

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Somatostatin receptor (SSTR) subtype-selective analogues differentially suppress in vitro growth hormone and prolactin in human pituitary adenomas. Novel potential therapy for functional pituitary tumors

21 January 2018

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Novel long-acting somatostatin analog with endocrine selectivity: potent suppression of growth hormone but not of insulin

21 January 2018

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Drug-induced disorders of glucose metabolism. Mechanisms and management

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Treatment with a somatostatin analog decreases pancreatic B-cell and whole body sensitivity to glucose.

21 January 2018

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Use of octreotide acetate to prevent rebound hypoglycaemia in sulfonylurea overdose

21 January 2018

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Intestinal absorption of octreotide using trimethyl chitosan chloride: studies in pigs

21 January 2018

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Inhibitory effects of octreotide on luminal cholecystokinin-releasing factor, plasma cholecystokinin, and pancreatic secretion in conscious rats

21 January 2018

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Selective agonism in somatostatin receptor signaling and regulation

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.2010.493935

Novel insights in somatostatin receptor physiology.

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.2010.493935

Vasculoprotective effects of somatostatin receptor subtypes

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.2010.493935

Somatostatin analogs - from new molecules to new applications

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.2010.493935

Rationale for the use of somatostatin analogs as antitumor agents

21 January 2018

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Differential expression of somatostatin receptor subtypes in hepatocellular carcinomas

21 January 2018

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Peptide-based probes for cancer imaging

21 January 2018

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Effect of octreotide on gall stone prevalence and gall bladder motility in acromegaly

21 January 2018

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Rapid identification of subtype-selective agonists of the somatostatin receptor through combinatorial chemistry

21 January 2018

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Novel, potent, and radio-iodinatable somatostatin receptor 1 (sst1) selective analogues

21 January 2018

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Somatostatin receptor 1 selective analogues: 4. Three-dimensional consensus structure by NMR.

21 January 2018

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Novel sst2-selective somatostatin agonists. Three-dimensional consensus structure by NMR

21 January 2018

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Three-dimensional consensus structure of sst2-selective somatostatin (SRIF) antagonists by NMR.

21 January 2018

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Novel sst(4)-selective somatostatin (SRIF) agonists. 4. Three-dimensional consensus structure by NMR.

21 January 2018

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A novel somatostatin mimic with broad somatotropin release inhibitory factor receptor binding and superior therapeutic potential.

21 January 2018

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Conformational and topographical considerations in designing agonist peptidomimetics from peptide leads

21 January 2018

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SMS 201–995: A very potent and selective octapeptide analogue of somatostatin with prolonged action

21 January 2018

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Ring size in octreotide amide modulates differently agonist versus antagonist binding affinity and selectivity

21 January 2018

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Arg-Gly-Asp constrained within cyclic pentapeptides. Strong and selective inhibitors of cell adhesion to vitronectin and laminin fragment P1.

21 January 2018

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N-Methylated cyclic RGD peptides as highly active and selective alpha(V)beta(3) integrin antagonists

21 January 2018

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Facile synthesis of orthogonally protected amino acid building blocks for combinatorial N-backbone cyclic peptide chemistry

21 January 2018

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Building Units for N-Backbone Cyclic Peptides. 3. Synthesis of Protected N(alpha)-(omega-Aminoalkyl)amino Acids and N(alpha)-(omega-Carboxyalkyl)amino Acids

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.2010.493935

Synthesis of novel protected Nalpha(omega-thioalkyl) amino acid building units and their incorporation in backbone cyclic disulfide and thioetheric bridged peptides

21 January 2018

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Miniaturized proteins: the backbone cyclic proteinomimetic approach

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.2010.493935

Effect of structural and conformation modifications, including backbone cyclization, of hydrophilic hexapeptides on their intestinal permeability and enzymatic stability

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.2010.493935

A backbone-cyclic, receptor 5-selective somatostatin analogue: synthesis, bioactivity, and nuclear magnetic resonance conformational analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2010.493935

A bicyclic and hsst2 selective somatostatin analogue: design, synthesis, conformational analysis and binding.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2010.493935

Human somatostatin receptor specificity of backbone-cyclic analogues containing novel sulfur building units

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2010.493935

N-methylation of peptides: a new perspective in medicinal chemistry

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2010.493935

N-Methyl scan of somatostatin octapeptide agonists produces interesting effects on receptor subtype specificity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2010.493935

Optimized selective N-methylation of peptides on solid support

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2010.493935

Somatostatin receptor subtypes 2 and 5 inhibit corticotropin-releasing hormone-stimulated adrenocorticotropin secretion from AtT-20 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2010.493935

Characterization of new selective somatostatin receptor subtype-2 (sst2) antagonists, BIM-23627 and BIM-23454. Effects of BIM-23627 on GH release in anesthetized male rats after short-term high-dose dexamethasone treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2010.493935

Nonpeptidyl somatostatin agonists demonstrate that sst2 and sst5 inhibit stimulated growth hormone secretion from rat anterior pituitary cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2010.493935

The structure and function of G-protein-coupled receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2010.493935

G protein-coupled receptor hetero-dimerization: contribution to pharmacology and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2010.493935

Dimerization of G protein-coupled receptors: new avenues for somatostatin receptor signalling, control and functioning

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2010.493935

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2010.493935

Molecular properties that influence the oral bioavailability of drug candidates

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2010.493935

Convenient synthesis of N-methylamino acids compatible with Fmoc solid-phase peptide synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2010.493935

Drug design at peptide receptors: somatostatin receptor ligands

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2010.493935

Subtype selectivity of peptide analogs for all five cloned human somatostatin receptors (hsstr 1-5).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2010.493935

Proteolytic studies of homologous peptide and N-substituted glycine peptoid oligomers

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2010.493935

Comparison of the proteolytic susceptibilities of homologous L-amino acid, D-amino acid, and N-substituted glycine peptide and peptoid oligomers

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2010.493935

A potent cyclic hexapeptide analogue of somatostatin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2010.493935

Highly selective cyclic hexapeptides antagonist of GPIIb-IIIa by multiple N-methylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2010.493935

Somatostatin Receptor Gene Family - Subtype Selectivity for Ligand Binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2010.493935

Improving Oral Bioavailability of Peptides by Multiple N-Methylation: Somatostatin Analogues

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2010.493935

10.1517/17460441.2010.493935

21 January 2018

Identifiers

DOI

1 reference

27 August 2017

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