Understanding the native nucleus pulposus cell phenotype has important implications for intervertebral disc regeneration strategies. (Q38069235)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23259807%20AND%20SRC:MED&resulttype=core&format=json

21 February 2020

review article

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title

Understanding the native nucleus pulposus cell phenotype has important implications for intervertebral disc regeneration strategies (English)

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21 February 2020

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3

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21 February 2020

author name string

Francesca E Ludwinski

series ordinal

1

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21 February 2020

Kanna Gnanalingham

series ordinal

2

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21 February 2020

Judith A Hoyland

series ordinal

4

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21 February 2020

publication date

1 January 2013

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21 February 2020

published in

Regenerative Medicine

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21 February 2020

volume

8

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21 February 2020

issue

1

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21 February 2020

page(s)

75-87

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23259807%20AND%20SRC:MED&resulttype=core&format=json

Prevalence of low back pain in the community: implications for service provision in Bradford, UK.

21 February 2020

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Pain and disability correlated with disc degeneration via magnetic resonance imaging in scoliosis patients

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Degeneration of the cervical disc: histology compared with radiography and magnetic resonance imaging

21 January 2018

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The structure and degradation of aggrecan in human intervertebral disc

21 January 2018

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21 January 2018

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Degeneration and the chemical composition of the human lumbar intervertebral disc

21 January 2018

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Caveolin-1 expression and stress-induced premature senescence in human intervertebral disc degeneration.

21 January 2018

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Accelerated cellular senescence in degenerate intervertebral discs: a possible role in the pathogenesis of intervertebral disc degeneration

21 January 2018

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'Rumours of my death may have been greatly exaggerated': a brief review of cell death in human intervertebral disc disease and implications for cell transplantation therapy

21 January 2018

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Matrix metalloproteinase 28, a novel matrix metalloproteinase, is constitutively expressed in human intervertebral disc tissue and is present in matrix of more degenerated discs

21 January 2018

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The reaction of bone to tumor growth from human breast cancer cells in a rat spine single metastasis model

21 January 2018

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Tumor necrosis factor-alpha modulates matrix production and catabolism in nucleus pulposus tissue

21 January 2018

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Modified expression of the ADAMTS enzymes and tissue inhibitor of metalloproteinases 3 during human intervertebral disc degeneration

21 January 2018

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Expression of chondrocyte markers by cells of normal and degenerate intervertebral discs

21 January 2018

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Disc cell clusters in pathological human intervertebral discs are associated with increased stress protein immunostaining

21 January 2018

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Differential expression level of cytokeratin 8 in cells of the bovine nucleus pulposus complicates the search for specific intervertebral disc cell markers

21 January 2018

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Incidence and prevalence of surgery at segments adjacent to a previous posterior lumbar arthrodesis.

21 January 2018

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Osteogenic protein-1 injection into a degenerated disc induces the restoration of disc height and structural changes in the rabbit anular puncture model

21 January 2018

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Exogenous and autocrine growth factors stimulate human intervertebral disc cell proliferation via the ERK and Akt pathways.

21 January 2018

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Biological repair of the degenerated intervertebral disc by the injection of growth factors

21 January 2018

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Characterization of the human nucleus pulposus cell phenotype and evaluation of novel marker gene expression to define adult stem cell differentiation.

21 January 2018

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Regenerative effects of transplanting mesenchymal stem cells embedded in atelocollagen to the degenerated intervertebral disc

21 January 2018

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Human mesenchymal stem cell differentiation to NP-like cells in chitosan-glycerophosphate hydrogels

21 January 2018

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Transplantation of mesenchymal stem cells in a canine disc degeneration model.

21 January 2018

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Intervertebral disc repair by autologous mesenchymal bone marrow cells: a pilot study

21 January 2018

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Differential phenotype of intervertebral disc cells: microarray and immunohistochemical analysis of canine nucleus pulposus and anulus fibrosus

21 January 2018

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A phenotypic comparison of intervertebral disc and articular cartilage cells in the rat.

21 January 2018

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Transcriptional profiling of bovine intervertebral disc cells: implications for identification of normal and degenerate human intervertebral disc cell phenotypes

21 January 2018

1 reference

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Identification of cell surface-specific markers to target human nucleus pulposus cells: expression of carbonic anhydrase XII varies with age and degeneration.

21 January 2018

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Identification of nucleus pulposus precursor cells and notochordal remnants in the mouse: implications for disk degeneration and chordoma formation

21 January 2018

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Molecular phenotypes of notochordal cells purified from immature nucleus pulposus

21 January 2018

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A phenotypic comparison of proteoglycan production of intervertebral disc cells isolated from rats, rabbits, and bovine tails; which animal model is most suitable to study tissue engineering and biological repair of human disc disorders?

21 January 2018

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Comparison of animal discs used in disc research to human lumbar disc: torsion mechanics and collagen content

21 January 2018

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Variations in gene and protein expression in human nucleus pulposus in comparison with annulus fibrosus and cartilage cells: potential associations with aging and degeneration.

21 January 2018

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Intermediate filament typing of the human embryonic and fetal notochord.

21 January 2018

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Detection and distribution of the carbohydrate binding protein galectin-3 in human notochord, intervertebral disc and chordoma

21 January 2018

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Brachyury, a crucial regulator of notochordal development, is a novel biomarker for chordomas

21 January 2018

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Development and degeneration of the intervertebral discs

21 January 2018

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The notochordal cell in the nucleus pulposus: a review in the context of tissue engineering

21 January 2018

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Collagen II is essential for the removal of the notochord and the formation of intervertebral discs

21 January 2018

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Analyzing notochord segmentation and intervertebral disc formation using the twhh:gfp transgenic zebrafish model.

21 January 2018

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The development of fibrocartilage in the rat intervertebral disc

21 January 2018

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Injury-induced sequential transformation of notochordal nucleus pulposus to chondrogenic and fibrocartilaginous phenotype in the mouse.

21 January 2018

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Nuclei pulposi formation from the embryonic notochord occurs normally in GDF-5-deficient mice

21 January 2018

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Shh signaling from the nucleus pulposus is required for the postnatal growth and differentiation of the mouse intervertebral disc

21 January 2018

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Hedgehog signaling is required for formation of the notochord sheath and patterning of nuclei pulposi within the intervertebral discs

21 January 2018

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Immunohistochemical identification of notochordal markers in cells in the aging human lumbar intervertebral disc

21 January 2018

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Toward an understanding of the role of notochordal cells in the adult intervertebral disc: from discord to accord

21 January 2018

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Evidence for skeletal progenitor cells in the degenerate human intervertebral disc.

21 January 2018

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In vivo growth factor treatment of degenerated intervertebral discs

21 January 2018

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Regenerative potential of TGFβ3 + Dex and notochordal cell conditioned media on degenerated human intervertebral disc cells

21 January 2018

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Notochordal conditioned media from tissue increases proteoglycan accumulation and promotes a healthy nucleus pulposus phenotype in human mesenchymal stem cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FRME.12.108

Notochordal cell conditioned medium stimulates mesenchymal stem cell differentiation toward a young nucleus pulposus phenotype

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FRME.12.108

Notochordal intervertebral disc cells: sensitivity to nutrient deprivation

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FRME.12.108

Sensitivity of notochordal disc cells to mechanical loading: an experimental animal study

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FRME.12.108

Notochordal cells protect nucleus pulposus cells from degradation and apoptosis: implications for the mechanisms of intervertebral disc degeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FRME.12.108

The cellular pathobiology of the degenerate intervertebral disc and discogenic back pain.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FRME.12.108

Classification of age-related changes in lumbar intervertebral discs: 2002 Volvo Award in basic science

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FRME.12.108

The role of the physicochemical environment in determining disc cell behaviour

21 January 2018

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https://api.crossref.org/works/10.2217%2FRME.12.108

Nutrient supply and intervertebral disc metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FRME.12.108

Oxygen and lactate concentrations measured in vivo in the intervertebral discs of patients with scoliosis and back pain

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FRME.12.108

In Vitro Diffusion of DYE Through the End-Plates and the Annulus Fibrosus of Human Lumbar Inter-Vertebral Discs

21 January 2018

1 reference

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2001 Volvo Award Winner in Basic Science Studies: Effect of nutrient supply on the viability of cells from the nucleus pulposus of the intervertebral disc

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FRME.12.108

The influence of serum, glucose and oxygen on intervertebral disc cell growth in vitro: implications for degenerative disc disease

21 January 2018

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https://api.crossref.org/works/10.2217%2FRME.12.108

Effect of oxygen levels on proteoglycan synthesis by intervertebral disc cells.

21 January 2018

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https://api.crossref.org/works/10.2217%2FRME.12.108

Nucleus pulposus cells express HIF-1 alpha under normoxic culture conditions: a metabolic adaptation to the intervertebral disc microenvironment

21 January 2018

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https://api.crossref.org/works/10.2217%2FRME.12.108

Hypoxia activates the notch signaling pathway in cells of the intervertebral disc: implications in degenerative disc disease

21 January 2018

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The effect of extracellular pH on matrix turnover by cells of the bovine nucleus pulposus

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FRME.12.108

Expression of acid-sensing ion channel 3 (ASIC3) in nucleus pulposus cells of the intervertebral disc is regulated by p75NTR and ERK signaling

21 January 2018

1 reference

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The role of interleukin-1 in the pathogenesis of human intervertebral disc degeneration

21 January 2018

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Human nucleus pulposus cells react to IL-6: independent actions and amplification of response to IL-1 and TNF-α.

21 January 2018

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Interleukin-1 receptor antagonist delivered directly and by gene therapy inhibits matrix degradation in the intact degenerate human intervertebral disc: an in situ zymographic and gene therapy study

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FRME.12.108

Behavior of mesenchymal stem cells in the chemical microenvironment of the intervertebral disc

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FRME.12.108

Hypoxia reduces the inhibitory effect of IL-1beta on chondrogenic differentiation of FCS-free expanded MSC.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FRME.12.108

Interleukin-1beta and tumor necrosis factor alpha inhibit chondrogenesis by human mesenchymal stem cells through NF-kappaB-dependent pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FRME.12.108

Notochordal Cell Produce and Assemble Extracellular Matrix in a Distinct Manner, Which May Be Responsible for the Maintenance of Healthy Nucleus Pulposus

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FRME.12.108

21 January 2018

Identifiers

DOI

10.2217/RME.12.108

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23259807%20AND%20SRC:MED&resulttype=core&format=json

release_6nozdrst5ffl5fwwsgashv2wfu

21 February 2020

Fatcat ID

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Fatcat

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mapped directly with Wikidata item

24 November 2022

based on heuristic

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