RB1 in cancer: different mechanisms of RB1 inactivation and alterations of pRb pathway in tumorigenesis. (Q38077510)

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22 February 2020

review article

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title

RB1 in cancer: different mechanisms of RB1 inactivation and alterations of pRb pathway in tumorigenesis (English)

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22 February 2020

1

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22 February 2020

Antonella D'Anneo

series ordinal

2

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22 February 2020

3

Giovanni Tesoriere

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22 February 2020

4

Renza Vento

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22 February 2020

language of work or name

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1 August 2013

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Journal of Cellular Physiology

22 February 2020

published in

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22 February 2020

volume

228

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22 February 2020

issue

8

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22 February 2020

page(s)

1676-1687

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Retinoblastoma in the 20th century: past success and future challenges the Weisenfeld lecture

22 February 2020

cites work

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NEDDylation controls the target specificity of E2F1 and apoptosis induction.

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Rb depletion results in deregulation of E-cadherin and induction of cellular phenotypic changes that are characteristic of the epithelial-to-mesenchymal transition.

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Induction of ZEB proteins by inactivation of RB protein is key determinant of mesenchymal phenotype of breast cancer.

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A novel repressive E2F6 complex containing the polycomb group protein, EPC1, that interacts with EZH2 in a proliferation-specific manner

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Mullerian Inhibiting Substance inhibits cervical cancer cell growth via a pathway involving p130 and p107.

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The retinoblastoma protein tumor suppressor is important for appropriate osteoblast differentiation and bone development

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Transformation of human and murine fibroblasts without viral oncoproteins

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Retinoblastoma protein recruits histone deacetylase to repress transcription

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Direct transcriptional repression by pRB and its reversal by specific cyclins

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Hyperphosphorylation of pRb: a mechanism for RB tumour suppressor pathway inactivation in bladder cancer

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Adenovirus E1A, simian virus 40 tumor antigen, and human papillomavirus E7 protein share the capacity to disrupt the interaction between transcription factor E2F and the retinoblastoma gene product

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Cooperation between Rb and Arf in suppressing mouse retinoblastoma.

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One hit, two hits, three hits, more? Genomic changes in the development of retinoblastoma.

21 January 2018

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Frequent loss of pRb2/p130 in human ovarian carcinoma

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Epithelial ovarian cancer: the role of cell cycle genes in the different histotypes

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Paclitaxel and beta-lapachone synergistically induce apoptosis in human retinoblastoma Y79 cells by downregulating the levels of phospho-Akt.

21 January 2018

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Differentiative pathway activated by 3-aminobenzamide, an inhibitor of PARP, in human osteosarcoma MG-63 cells.

21 January 2018

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Modeling the effect of the RB tumor suppressor on disease progression: dependence on oncogene network and cellular context

21 January 2018

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How the Rb tumor suppressor structure and function was revealed by the study of Adenovirus and SV40.

21 January 2018

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E2F8 contributes to human hepatocellular carcinoma via regulating cell proliferation.

21 January 2018

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Loss of RB1 induces non-proliferative retinoma: increasing genomic instability correlates with progression to retinoblastoma

21 January 2018

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Physical interaction of the retinoblastoma protein with human D cyclins

21 January 2018

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The retinoblastoma protein and BRG1 form a complex and cooperate to induce cell cycle arrest

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Emerging insights into the molecular and cellular basis of glioblastoma

21 January 2018

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The regulation of E2F by pRB-family proteins

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A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma

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Unusual proliferation arrest and transcriptional control properties of a newly discovered E2F family member, E2F-6

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E2F4 is exported from the nucleus in a CRM1-dependent manner.

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Cell cycle control and beyond: emerging roles for the retinoblastoma gene family

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Role of insulin-like growth factors in autocrine growth of human retinoblastoma Y79 cells

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Loss of 9p leads to p16INK4A down-regulation and enables RB/E2F1-dependent cell cycle promotion in gastrointestinal stromal tumours (GISTs).

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Deficiency of pRb family proteins and p53 in invasive urothelial tumorigenesis.

21 January 2018

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The retinoblastoma family of proteins and their regulatory functions in the mammalian cell division cycle

21 January 2018

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The interaction of RB with E2F coincides with an inhibition of the transcriptional activity of E2F

21 January 2018

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Molecular detection of chromosomal translocations that disrupt the putative retinoblastoma susceptibility locus

21 January 2018

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E2F-5, a new E2F family member that interacts with p130 in vivo

21 January 2018

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Structure of the human retinoblastoma gene

21 January 2018

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Inactivation of the Rb pathway and overexpression of both isoforms of E2F3 are obligate events in bladder tumours with 6p22 amplification.

21 January 2018

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E2F2 represses cell cycle regulators to maintain quiescence.

21 January 2018

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Molecular changes in mesothelioma with an impact on prognosis and treatment

21 January 2018

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Expression of retinoblastoma protein and P16 proteins in classic Hodgkin lymphoma: relationship with expression of p53 and presence of Epstein-Barr virus in the regulation of cell growth and death

21 January 2018

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Mutation and cancer: statistical study of retinoblastoma

21 January 2018

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E2F5 status significantly improves malignancy diagnosis of epithelial ovarian cancer

21 January 2018

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Isolation of human chromosome 13-specific DNA sequences cloned from flow sorted chromosomes and potentially linked to the retinoblastoma locus

21 January 2018

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Atypical E2Fs: new players in the E2F transcription factor family

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Emerging roles of DNA tumor viruses in cell proliferation: new insights into genomic instability.

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Human retinoblastoma susceptibility gene: cloning, identification, and sequence

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The retinoblastoma protein binds to a family of E2F transcription factors

21 January 2018

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Synergistic function of E2F7 and E2F8 is essential for cell survival and embryonic development.

21 January 2018

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Evolutionarily conserved multisubunit RBL2/p130 and E2F4 protein complex represses human cell cycle-dependent genes in quiescence

21 January 2018

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Downregulation of CDKN2A and suppression of cyclin D1 gene expressions in malignant gliomas

21 January 2018

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21 January 2018

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Insights from mouse models into human retinoblastoma

21 January 2018

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Effect of promoter methylation of the p16 gene on phosphorylation of retinoblastoma gene product and growth of hepatocellular carcinoma cells

21 January 2018

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E2F-4 switches from p130 to p107 and pRB in response to cell cycle reentry

21 January 2018

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Protein expression of the RB-related gene family and SV40 large T antigen in mesothelioma and lung cancer

21 January 2018

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BRCA1: the enigma of tissue-specific tumor development.

21 January 2018

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E2F7 and E2F8 keep the E2F family in balance

21 January 2018

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Cyclin D1 overexpression, p16 loss, and pRb inactivation play a key role in pulmonary carcinogenesis and have a prognostic implication for the long-term survival in non-small cell lung carcinoma patients

21 January 2018

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G1 to S phase cell cycle transition in somatic and embryonic stem cells.

21 January 2018

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CDKN2A gene deletions and loss of p16 expression occur in osteosarcomas that lack RB alterations

21 January 2018

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E2F6 negatively regulates BRCA1 in human cancer cells without methylation of histone H3 on lysine 9.

21 January 2018

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Inhibition of pituitary tumors in Rb mutant chimeras through E2f4 loss reveals a key suppressive role for the pRB/E2F pathway in urothelium and ganglionic carcinogenesis

21 January 2018

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9p21 locus analysis in high-risk gastrointestinal stromal tumors characterized for c-kit and platelet-derived growth factor receptor alpha gene alterations.

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Sensitive and efficient detection of RB1 gene mutations enhances care for families with retinoblastoma

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21 January 2018

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p107 is a suppressor of retinoblastoma development in pRb-deficient mice

21 January 2018

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21 January 2018

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21 January 2018

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pRb inactivation in mammary cells reveals common mechanisms for tumor initiation and progression in divergent epithelia

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Perturbation of Rb, p53, and Brca1 or Brca2 cooperate in inducing metastatic serous epithelial ovarian cancer

21 January 2018

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21 January 2018

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Molecular classification identifies a subset of human papillomavirus--associated oropharyngeal cancers with favorable prognosis

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Rb is critical in a mammalian tissue stem cell population

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E2F7 represses a network of oscillating cell cycle genes to control S-phase progression

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The retinoblastoma protein is required for Ras-induced oncogenic transformation

21 January 2018

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A p16INK4a-insensitive CDK4 mutant targeted by cytolytic T lymphocytes in a human melanoma

21 January 2018

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E2F1-mediated apoptosis as a target of cancer therapy

21 January 2018

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Extra-embryonic function of Rb is essential for embryonic development and viability

21 January 2018

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Novel link between E2F1 and Smac/DIABLO: proapoptotic Smac/DIABLO is transcriptionally upregulated by E2F1.

21 January 2018

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Subunit rearrangement of the cyclin-dependent kinases is associated with cellular transformation

21 January 2018

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A cluster of cooperating tumor-suppressor gene candidates in chromosomal deletions

21 January 2018

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Somatic inactivation of genes on chromosome 13 is a common event in retinoblastoma

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/JCP.24329

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23359405%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

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